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Invest Ophthalmol Vis Sci 2002;43: E-Abstract 373.
© 2002 ARVO

Diclofenac versus Prednisolone Postphacoemusfication Treatment: A Randomized Clinical Trial

A Voudouri1, P Zafirakis2, G Livir-Rallatos1, C Livir-Rallatos3, C Canakis4 and N Markomichelakis5

1 Ophthalmology Athens Ophthalmic Center Athens Greece
2 Ophthalmology Zafirakis Eye Center Athens Greece
3 Ophthalmology Tulane University New Orleans LA
4 Ophthalmology Tulane University Athens LA
5 Ophthalmology General Hospital of Athens Athens Greece

Commercial Relationships:  A. Voudouri, None; P. Zafirakis, None; G. Livir-Rallatos, None; C. Livir-Rallatos, None; C. Canakis, None; N. Markomichelakis, None.


Purpose: To evaluate the efficacy of diclofenac sodium 0.1% and prednisolone acetate 1.0% ophthalmic solutions in the treatment of post-phacoemulsification cataract surgery and foldable intraocular lens implantation. Methods: One hundred consecutive eyes scheduled for clear corneal phacoemulsification cataract surgery were prospectively randomized to receive either diclofenac or prednislone for postoperative treatment. Postoperative discomfort, redness, best-corrected visual acuity (BCVA), signs of inflammation and intraocular pressure (IOP) were assessed at each visit. To assess postoperative discomfort or pain, a visual linear 10-point pain scale was usedon which patients were asked to indicate their discomfort or pain on a scale from 0 (no pain) to 10 (maximum pain). Results: Ninety-eight eyes (98 patients) completed the study. The mean age of the 40 men and 48 women was 76.0 years + 6.4 (SD) (range 50 to 81 years). Diclofenac patients reported significant less postoperative discomfort. No differences in postoperative inflammation, IOP, and BCVA were noted. Patients on diclofenac resulted in faster wound healing. Conclusions: Diclofenac may be as effective and as safe as prednisolone in controlling postoperative inflammation whitout having the side effects of prednisolone.

Keywords: 338 cataract • 357 clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials

 © 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. For permission to reproduce any part of this abstract, contact the ARVO Office at arvo{at}