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In Vitro Susceptibilities to Antimicrobials of Pathogens Isolated from the Vitreous Cavity of Patients with Endophthalmitis

^A Ophthalmology^B Ophthalmology and Microbiology¹ Bascom Palmer Eye Institute Miami FL

Commercial Relationships:  M.S. Benz, None; I.U. Scott, None; H.W. Flynn, None; D. Miller, None.

Abstract

Purpose: To investigate the spectrum of organisms causing culture-proven endophthalmitis and their sensitivities to commonly used antimicrobial agents.
Methods: Medical records were reviewed of all patients with culture-proven endophthalmitis at a single institution between January 1, 1996 and December 31,2000.
Results: 260 organisms were isolated from 230 patients during the study interval. Staphylococcus epidermidis (71/260;27%), Streptococcus viridans group (37/260;15%), and coagulase-negative staphylococci (26/260;10%) were found to be the most common infecting microbes. Overall, 211 of 260 (81%) of cases were caused by gram-positive organisms, 32 of 260 (13%) by gram-negative organisms, and 14 of 260 (5%) by fungi. Of gram-positive organisms, 100% were sensitive to vancomycin, 75% were sensitive to gentamicin, 70% were sensitive to ciprofloxacin, and 40% were sensitive to penicillin. Of gram-negative organisms, 70% were sensitive to gentamicin and 92% were sensitive to ciprofloxacin.
Conclusion: No single antibiotic provided coverage for all of the microbes isolated from eyes with endophthalmitis.

Keywords: 398 endophthalmitis • 319 antibiotics/antifungals/antiparasitics • 468 microbial pathogenesis: clinical studies

© 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. For permission to reproduce any part of this abstract, contact the ARVO Office at arvo{at}arvo.org.