ARVO Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alexander, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Alexander, J.
Invest Ophthalmol Vis Sci 2004;45: E-Abstract 2989.
© 2004 ARVO

2989—B624

Characteristics of Exudation in Patients with Bilateral Large Drusen

J. Alexander1, K.S. Elsner1, N.B. Javornik1, E.R. Whittock1, M. Brightwell–Arnold1, J.L. Duncan2, R.A. Stoltz1, S.L. Fine1 and CAPT Study Group

1 Scheie Eye Institute – University of Pennsylvania, Philadelphia, PA
2 Department of Ophthalmology, University of California, San Francisco, CA

Commercial Relationships: J. Alexander, None; K.S. Elsner, None; N.B. Javornik, None; E.R. Whittock, None; M. Brightwell–Arnold, None; J.L. Duncan, None; R.A. Stoltz, None; S.L. Fine, None.

Grant Identification: NIH/NEI Grant EY12211

Abstract

Purpose:To describe the characteristics of newly diagnosed choroidal neovascularization (CNV) and serous detachment of the pigment epithelium (S–PED) in untreated eyes of patients with bilateral large drusen.

Methods:The fluorescein angiograms (FAs) of 1052 patients participating in the Complications of AMD Prevention Trial (CAPT) were graded for the presence of CNV or S–PED. At baseline, eligible patients had >10 large (>125 µ) drusen in each eye. FAs are performed at baseline, annual visits, and whenever the CAPT ophthalmologist suspects that CNV has developed. Lesion composition (classic and/or occult), size (MPS Disc Areas), and location (subfoveal or not) were recorded for CNV developing in untreated eyes. Visual acuity was measured by certified examiners following a standard protocol.

Results:Among the first 67 untreated eyes identified with exudation, 90% had CNV only, 9% had a combination of CNV and S–PED, and 1% had S–PED only. Among CNV lesions, 70% were occult only, 18% were classic and occult, and 7% were classic only. Approximately half (52%) were < 2 Disc Areas and all were < 9 Disc Areas. 57% of lesions were subfoveal. Visual acuity was 20/40 or better in 66% of the eyes at the first regularly scheduled visit with exudation. 56% of the subfoveal lesions and 80% of the non–subfoveal lesion had vision 20/40 or better.

Conclusions:The characteristics of CNV, in this closely monitored group of patients with bilateral large drusen, differs from the characteristics of CNV provided in published reports of case series from referral centers.

Keywords: age–related macular degeneration • drusen • clinical (human) or epidemiologic studies: natural history

© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. For permission to reproduce any part of this abstract, contact the ARVO Office at arvo{at}arvo.org.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH