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Invest Ophthalmol Vis Sci 2005;46: E-Abstract 334.
© 2005 ARVO

334—B308

Changes in Choroidal Blood Flow After Photodynamic Therapy in Age–Related Macular Degeneration

H. Kagokawa, A. Takahashi, A. Takamiya, F. Mori, Y. Minami, Y. Kato, R. Kinouchi, S. Ishiko and A. Yoshida

Dept Ophthalmology, Asahikawa Medical College, Asahikawa, Japan

Commercial Relationships: H. Kagokawa, None; A. Takahashi, None; A. Takamiya, None; F. Mori, None; Y. Minami, None; Y. Kato, None; R. Kinouchi, None; S. Ishiko, None; A. Yoshida, None.

Support: None.

Abstract

Purpose: We reported previously that pulsatile ocular blood flow (POBF), a parameter for evaluating choroidal blood flow, was lower in patients with exudative age–related macular degeneration (AMD) than in normal subjects (BJO. 2001; 85:531–533). The aim of this study is to evaluate the changes in choroidal blood flow after photodynamic therapy (PDT) in patients with exudative AMD.

Methods: Eight patients with exudative AMD (8 eyes; 6 men, 2 women; age range, 63–78 years) who underwent PDT were included. PDT with verteporfin (Visudyne®) was administered. We examined fluorescein angiography (FA), indocyanine green angiography (IA), and POBF using Langham OBF computerized tonometry before and 10 days after administration of PDT.

Results: The POBF 10 days after PDT (median, 578 µl/min) increased significantly compared to before PDT (median, 487 µl/min) (p< 0.05). Early–phase FA, and IA showed low fluorescence corresponding to the area of laser irradiation in the eye. There was no filling delay of the dye in the large choroidal vessels on IA.

Conclusions: The results of this study for the first time suggested that the choroidal blood flow may increase 10 days after PDT. It is possible that the choroidal blood flow increase compensates for the occluded choriocapillaris in the area of laser irradiation.

Keywords: photodynamic therapy • age-related macular degeneration • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled

© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. For permission to reproduce any part of this abstract, contact the ARVO Office at arvo{at}arvo.org.




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