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Invest Ophthalmol Vis Sci 2008;49: E-Abstract 2453.
© 2008 ARVO

2453

Prevalence of Early and Late Age-Related Macular Degeneration in India: The INDEYE Study

T. Krishnan1, R. D. Ravindran1, G. V. S. Murthy2, P. Vashist2, K. E. Fitzpatrick3, N. John2, G. Maraini4, M. Camparini4, U. Chakravarthy5 and A. E. Fletcher3

1Aravind Eye Hospital Pondicherry, Aravind Eye Care, Pondicherry, India
2Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
3Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
4Dipartimento di Scienze Otorino-Odonto-Oftalmologiche e Cervico Facciali, Sezione di Oftalmologia, Universita` degli Studi di Parma, Parma, Italy
5Ophthalmology and Vision Science, Queen's University Belfast, Belfast, United Kingdom

Commercial Relationships: T. Krishnan, None; R.D. Ravindran, None; G.V.S. Murthy, None; P. Vashist, None; K.E. Fitzpatrick, None; N. John, None; G. Maraini, None; M. Camparini, None; U. Chakravarthy, None; A.E. Fletcher, None.

Support: Wellcome Trust Grant G 073300

Abstract

Purpose:To describe the prevalence of early and late Age-Related Macular Degeneration (AMD) in older people in India.

Methods:People aged 60 years and older identified using random cluster-sampling in 2 study centres in south and north India, attended an eye examination. Digital fundus images were graded at a single reading centre according to the International Classification System and were stratified into 5 exclusive stages.

Results:2821 people (79% response rate) in north India and 3079 (78%) in south India attended an eye examination. 27% of participants with photographs could not be graded, mainly due to dense opacities, and are included in the denominator of prevalence estimates. The prevalence of late AMD was 0.9% (95% CI 0.7-1.1) and similar in the two centres (p=0.452), comprising mainly of neovascular AMD (44 of 53 cases). For early AMD, the prevalence of stage 1 (soft distinct drusen or pigmentary irregularities) was 28.8% (95% CI 27.0-30.6) with no difference seen between the centres (p=0.113). Differences were observed for stage 2 (soft distinct drusen with pigmentary irregularities or soft indistinct or reticular drusen), 3.8% (95% CI 2.7-5.0) in north India and 6.0% (95% CI 5.2-6.7) in South India, and for stage 3 (soft indistinct or reticular drusen with pigmentary irregularities), 0.04% (95% CI 0-0.1) in north India and 0.3% (95% CI 0.1-0.6) in south India.

Conclusions:The prevalence of early AMD (stages 1 and 2) is similar to that observed in western populations but stage 3 and late AMD prevalence appear to be lower. These estimates however are conservative because of the high proportion of ungradeables.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: prevalence/incidence

© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.




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