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Invest Ophthalmol Vis Sci 2008;49: E-Abstract 3832.
© 2008 ARVO


Arrangement of the Human Trichromatic Cone Mosaic in Peripheral Retina

O. Masuda1, H. Hofer2, J. Carroll3 and D. R. Williams1

1Ctr for Vis Science, University of Rochester, Rochester, New York
2College of Optometry, University of Houston, Houston, Texas
3Department of Ophthalmology, The Medical College of Wisconsin, Milwaukee, Wisconsin

Commercial Relationships: O. Masuda, None; H. Hofer, None; J. Carroll, None; D.R. Williams, Optos, Inc., C; adaptive optics, P.

Support: NIH EY04367, NIH EY01319 and the NSF Science and Technology Center for Adaptive Optics (cooperative agreement no.: AST-9876783 with UCSC)


Purpose:Previous studies have concluded that the packing arrangement of L and M cones near the center of the human fovea is not distinguishable from random in most eyes. We sought to determine whether this is also true for extrafoveal retina.

Methods:We classified the L, M, and S cones in one female color-normal subject with adaptive optics imaging combined with retinal densitometry at 1.25 , 4, and 10 deg in the temporal retina. We evaluated the packing arrangement of the 3 cone classes by comparing the frequencies of distances between all cones of the same type with those expected based on a random pigment assignment rule.

Results:314 cones were classified at 10 deg, 739 at 4 deg, and 1456 at 1.25 deg. The number of misidentified L and M cones at each location was estimated at 3.9 %, 2.8 %, and 2.5 % respectively. Though the ratio of L to M cones did not differ significantly across the eccentricities tested, peripheral L and M cones exhibited significant clumping whereas those at 1.25 deg did not.

Conclusions:The organization of L and M cones outside the fovea, at least in one subject, shows a clear tendency toward clumping of cones of like type. This clumping may have implications for the strength of red-green color vision in peripheral retina since it increases the probability that peripheral midget cell centers will be driven by predominantly one class of cone.

Keywords: retina • color vision • receptors

© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.