ARVO Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 QUICK SEARCH:   [advanced]


     


This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flatter, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Flatter, J.
Invest Ophthalmol Vis Sci 2013;54: E-Abstract 3627.
© 2013 ARVO


3627—D0356

Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma

John Flatter1, Michael Dubow4,2, Ravi Singh1, Nishit Shah2, Scott Robison1, David Weinberg1, Kimberly Stepien1, Alfredo Dubra1,3, Richard Rosen2, Joseph Carroll1,3 and Carroll lab

1 Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
2 Ophthalmology, New York Eye & Ear Infirmary, New York, NY
3 Biophysics, Medical College of Wisconsin, Milwaukee, WI
4 Mount Sinai School of Medicine, Mount Sinai Hospital, New York, NY

Commercial Relationships: John Flatter, None; Michael Dubow, None; Ravi Singh, None; Nishit Shah, None; Scott Robison, None; David Weinberg, Regeneron (F); Kimberly Stepien, None; Alfredo Dubra, US Patent No: 8,226,236 (P); Richard Rosen, Opko-OTI (C), Optos (C), Clarity (C), OD-OS (C), Topcon (R), Zeavision (F), Genetech (F), Optovue (C); Joseph Carroll, Imagine Eyes, Inc. (S)

Support: None

Abstract

Purpose:Closed globe blunt ocular trauma (cg-BOT) can result in vision loss that often cannot be clinically explained. Involvement of the posterior segment is often linked to poor visual outcomes, possibly due to chronic changes in retinal architecture. Currently, little is known on the impact of cg-BOT on photoreceptor structure. Here we used high-resolution retinal imaging to evaluate outer retinal structure in patients with visual deficits secondary to cg-BOT.

Methods:Imaging was performed between 1 mo and 3 yrs post-trauma. Fundus photography and spectral domain optical coherence tomography (SD-OCT) were used to assess macroscopic changes in retinal architecture in 8 subjects with cg-BOT. Adaptive optics scanning light ophthalmoscopy (AOSLO) was used to analyze the integrity of the photoreceptor mosaic, and Bioptigen SD-OCT was used to obtain high-resolution line scans through the fovea.

Results:Examined subjects had documented visual deficits ranging from central scotoma to larger field deficits and decreases in visual acuity. Acutely, 4 subjects had documented commotio retinae (CR) of the macula, 1 had peripheral CR, and 2 had choroidal rupture. SD-OCT revealed variable disruption of outer retinal architecture, whereas AOSLO revealed a disrupted foveal cone mosaic in all eyes. Cone mosaic disruption correlated with the extent of outer retinal disruption observed with SD-OCT. In addition, decreased cone density with local expansion of rods was seen in the perifoveal region in 3 eyes. Six eyes contained patches of non-waveguiding cones within the macula.

Conclusions:SD-OCT and AOSLO revealed outer retina structural deficits in individuals with varying degrees of injury following cg-BOT. AOSLO imaging provides a noninvasive way to assess photoreceptor structure at a level of detail not resolvable using conventional SD-OCT or other clinical imaging tools. It also appears useful for revealing the cause of visual complaints in patients following cg-BOT.


Figure 01
View larger version (122K):
[in this window]
[in a new window]

 
30 y/o male sustained cg-BOT, presented clinically with a small central scotoma OS and macular CR. BCVA was 20/20 OU. A) 6mm SD-OCT. B) AOSLO montage corresponding to arrows in A. C) Cut out from B revealing non-waveguiding cones.

 

Figure 02
View larger version (134K):
[in this window]
[in a new window]

 
34 y/o male sustained cg-BOT, presented clinically with a small central scotoma OD and peripheral CR. BCVA was 20/40 OD. A) 6mm SD-OCT. B) AOSLO montage corresponding to arrows in A. C) Cut out from B revealing focal disruption of photoreceptor mosaic.

 

Keywords: 742 trauma • 585 macula/fovea • 551 imaging/image analysis: non-clinical

© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH