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Invest Ophthalmol Vis Sci 2013;54: E-Abstract 5825.
© 2013 ARVO


5825—D0136

Retinal Morphology Changes After Epiretinal Membrane Peeling

Judy Kim1, Nathan Mathews1 and Sergey Tarima2

1 Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
2 Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI

Commercial Relationships: Judy Kim, None; Nathan Mathews, None; Sergey Tarima, None

Support: None

Abstract

Purpose:To determine whether the morphologic appearance of the foveal contour and the continuity of the IS/OS junction as assessed with optical coherence tomography (OCT) of patients presenting with epiretinal membrane (ERM) correlate with changes in best corrected visual acuity (BCVA), central retinal thickness (CRT), central subfield thickness (CST) and volume (CSV) following pars plana vitrectomy (PPV) for ERM removal with internal limiting membrane (ILM) peel.

Methods:Images from consecutive forty-seven subjects were analyzed retrospectively. Foveal contour grades were determined by 2 independent graders using radial line scans at 30° intervals. Grades were classified as 0 (fovea thinner than surrounding macula), 1 (flat), and 2 (fovea thicker than surrounding macula). In cases of observer disagreement, OCT-derived thickness values of the retina at the fovea and 1 mm radially from the fovea were used to generate quantifiable thickness profiles and applied as tiebreakers. The continuity of the IS/OS junction was assessed on 6 radial line scans. CST and CSV data were collected from OCT-generated map.

Results:40 of the 47 subjects had both preoperative and 3 month follow-up OCT. 29 of these 40 were Grade 2 preoperatively, 11 were Grade 1, and none were Grade 0. 14 of the 29 Grade 2 subjects resolved to Grade 0/1, while 3 of the preoperative Grade 0/1 subjects were Grade 2 at 3 months (McNemar test, P=0.013).Preoperative CRT, CST, and CSV values were negatively correlated with the changes in CRT (P<0.001), CST (P<0.001), and CSV (P<0.001), respectively, at 90 days. Foveal contour grade was not significantly correlated to the change in these outcome values (P>0.05). BCVA was not found to improve significantly in preoperative Grade 0/1 patients (-0.11 LogMar units, P=0.122), nor in preoperative Grade 2 patients (-0.04, P=0.380), at 3 months. No significant difference in BCVA changes between groups was found (P=0.420). However, linear mixed model analysis with random subject effect demonstrated a statistically significant improvement in BCVA (regression coefficient = 0.01 LogMar units, P=0.048) when controlling for the confounding effects of lens status (0.18, P=0.001) and baseline IS/OS junction disruption (0.15, P=0.012).

Conclusions:Preoperative IS/OS junction disruption and postoperative cataract progression, but not preoperative foveal contour grade, significantly affect BCVA following PPV for ERM removal with ILM peel.

Keywords: 585 macula/fovea • 550 imaging/image analysis: clinical • 762 vitreoretinal surgery

© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.





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