Biochemistry and Molecular Biology

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Retina October 2021

Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1 + Macrophage Infiltration

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Iori Wada; Shintaro Nakao; Muneo Yamaguchi; Yoshihiro Kaizu; Mitsuru Arima; Shinichiro Sawa; Koh-Hei Sonoda
TAGS: diabetic retinopathy, lymphangiogenesis, lymphatic vessels, macrophages, mice, protein overexpression, retina, vascular endothelial growth factor a, vascular endothelial growth factor c, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):17. doi: https://doi.org/10.1167/iovs.62.13.17

Includes: Supplemental Content

Cornea October 2021

USP10 Promotes Fibronectin Recycling, Secretion, and Organization

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Andrew T. Phillips; Edward F. Boumil; Nileyma Castro; Arunkumar Venkatesan; Eugenio Gallo; Jarrett J. Adams; Sachdev S. Sidhu; Audrey M. Bernstein
TAGS: bodily secretions, dna, complementary, fibronectins, integrins, protein overexpression, antibodies, flow cytometry, fluorescein-5-isothiocyanate, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):15. doi: https://doi.org/10.1167/iovs.62.13.15

Includes: Supplemental Content

Cornea October 2021

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

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Hua Chen; Hui Gao; Hua-Tao Xie; Shu-Ting Liu; Yu-Kan Huang; Ming-Chang Zhang
TAGS: cytokine, meibomian gland, mice, staphylococcus aureus, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):11. doi: https://doi.org/10.1167/iovs.62.13.11

Clinical Trials September 2021

Integrating Clinical Data and Tear Proteomics to Assess Efficacy, Ocular Surface Status, and Biomarker Response After Orthokeratology Lens Wear

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Jimmy S.H. Tse; Jimmy K.W. Cheung; Gigi T.K. Wong; Thomas C. Lam; Kai Yip Choi; Katherine H.Y. So; Christie D.M. Lam; Andes Y.H. Sze; Angel C.K. Wong; Gigi M.C. Yee; Henry H.L. Chan
TAGS: biological markers, lens (device), lens, crystalline, orthokeratology, proteins, proteome, proteomics, safety, cornea
Trans. Vis. Sci. Tech.. 2021; 10(11):18. doi: https://doi.org/10.1167/tvst.10.11.18

Includes: Supplemental Content

Lens September 2021

Spatially Resolved Proteomic Analysis of the Lens Extracellular Diffusion Barrier

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Zhen Wang; Lee S. Cantrell; Kevin L. Schey
TAGS: diffusion, lens (device), lens, crystalline, proteins, proteomics
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):25. doi: https://doi.org/10.1167/iovs.62.12.25

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2021

Effects of Aging on Human Meibum

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Igor A. Butovich; Tomo Suzuki
TAGS: aging, lipids, significance, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):23. doi: https://doi.org/10.1167/iovs.62.12.23

Includes: Supplemental Content

Retina September 2021

CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X 7 in the Diabetic Retina

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Jin-Sang Yu; Jad Daw; Jose-Andres C. Portillo; Carlos S. Subauste
TAGS: cd40 antigens, diabetes mellitus, endothelial cells, intercellular adhesion molecule 1, retina, up-regulation (physiology), tumor necrosis factors, cytokine, diabetic retinopathy, mice
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):22. doi: https://doi.org/10.1167/iovs.62.12.22

Biochemistry and Molecular Biology September 2021

Novel Insights Into Muscarinic and Purinergic Responses in Primary Cultures of Rat Lacrimal Gland Myoepithelial Cells

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Martin Dankis; Thomas Carlsson; Patrik Aronsson; Gunnar Tobin; Michael Winder
TAGS: lacrimal gland, muscarinic acetylcholine receptor, patient isolation
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):19. doi: https://doi.org/10.1167/iovs.62.12.19

Biochemistry and Molecular Biology September 2021

The Potential Role of Osteopontin in the Pathogenesis of Graves’ Ophthalmopathy

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Heng Lou; Lian-Qun Wu; Hao Wang; Rui-Li Wei; Jin-Wei Cheng
TAGS: collagen, connective tissue, cytokine, graves' ophthalmopathy, osteopontin, pathogenesis, proteins, rna, messenger, cd40 ligand, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):18. doi: https://doi.org/10.1167/iovs.62.12.18

Retinal Cell Biology September 2021

The Role of the Wnt Pathway in VEGF/Anti-VEGF-Dependent Control of the Endothelial Cell Barrier

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Yueru Li; Basma Baccouche; Olamide Olayinka; Anara Serikbaeva; Andrius Kazlauskas
TAGS: endothelial cells, permeability, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, endothelium, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):17. doi: https://doi.org/10.1167/iovs.62.12.17

Includes: Supplemental Content

Article September 2021

Local and global context repetitions in contextual cueing

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Nils Bergmann; Anna Schubö
TAGS: attention, learning, reaction time, reward, color, use techniques of reflection and clarification in communication
Journal of Vision. 2021; 21(10):9. doi: https://doi.org/10.1167/jov.21.10.9

Glaucoma September 2021

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

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Naga Pradeep Rayana; Chenna Kesavulu Sugali; Jiannong Dai; Michael Peng; Shaohui Liu; Yucheng Zhang; Jun Wan; Weiming Mao
TAGS: crispr, eye, glaucoma, mice, ocular hypertension, cytomegalovirus, lentiviral vector, adenoviruses, genes
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):7. doi: https://doi.org/10.1167/iovs.62.12.7

Includes: Supplemental Content

Special Issue September 2021

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

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Van Phuc Nguyen; Yanxiu Li; Jessica Henry; Thomas Qian; Wei Zhang; Xueding Wang; Yannis M. Paulus
TAGS: diagnostic imaging, fluorescence, indocyanine green, injections, optical coherence tomography, cell tracking, regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):10. doi: https://doi.org/10.1167/tvst.10.10.10

Retina August 2021

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

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Dongfeng Cao; Belinda Leong; Jeffrey D. Messinger; Deepayan Kar; Thomas Ach; Lawrence A. Yannuzzi; K. Bailey Freund; Christine A. Curcio
TAGS: age-related macular degeneration, atrophic condition of skin, atrophy, cell transdifferentiation, diagnostic imaging, donors, eye, immunohistochemistry, optical coherence tomography, phenotype
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):34. doi: https://doi.org/10.1167/iovs.62.10.34

Includes: Supplemental Content

Immunology and Microbiology August 2021

Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes

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Shalem Raj Padakandla; Taraprasad Das; Gumpili Sai Prashanthi; Kiran Kumar Angadi; S. Sreenivasa Reddy; G. Bhanuprakash Reddy; Sisinthy Shivaji
TAGS: diabetes mellitus, intestinal bacteria, microbiome, rats, streptozocin, dysbiosis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):31. doi: https://doi.org/10.1167/iovs.62.10.31

Includes: Supplemental Content

Cornea August 2021

Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis

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Maite López-López; Uxía Regueiro; Susana B. Bravo; María del Pilar Chantada-Vázquez; Rubén Varela-Fernández; Paulo Ávila-Gómez; Pablo Hervella; Isabel Lema
TAGS: keratoconus, proteins, proteomics
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):30. doi: https://doi.org/10.1167/iovs.62.10.30

Includes: Supplemental Content

Glaucoma August 2021

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10

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Hang-Jing Wu; Douglas P. Mortlock; Rachel W. Kuchtey; John Kuchtey
TAGS: fibrillin-2, fibrillins, glaucoma, mice, microfibrils, mutation, fibrillin-1, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):26. doi: https://doi.org/10.1167/iovs.62.10.26

Cornea August 2021

Exploring the Mechanism of the miRNA-145/Paxillin Axis in Cell Metabolism During VEGF-A–Induced Corneal Angiogenesis

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Wanju Yang; Yanning Yang; Shanshan Wan; Ya Xu; Jing Li; Lu Zhang; Wanruo Guo; Yijun Zheng; Yi Xiang; Yiqiao Xing
TAGS: corneal neovascularization, metabolism, vascular endothelial growth factor a, micrornas, angiogenesis, lactic acid, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):25. doi: https://doi.org/10.1167/iovs.62.10.25

Articles August 2021

Comparison of Syringes With Intravitreal Anti-VEGF Drugs: Particle Burden and Protein Aggregates in Brolucizumab, Aflibercept and Bevacizumab

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Marc Schargus; Katharina Tatjana Kopp; Constanze Helbig; Andreas Frings; Gerhard Winter
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, bevacizumab, brolucizumab, syringes, protein aggregates, vial
Trans. Vis. Sci. Tech.. 2021; 10(9):21. doi: https://doi.org/10.1167/tvst.10.9.21

Retina August 2021

Analysis of the Aqueous Humor Proteome in Patients With Age-Related Macular Degeneration

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Batya Rinsky; Gala Beykin; Michelle Grunin; Radgonde Amer; Samer Khateb; Liran Tiosano; Diego Almeida; Shira Hagbi-Levi; Sarah Elbaz-Hayoun; Itay Chowers
TAGS: age-related macular degeneration, aqueous humor, hypertension, proteins, proteome, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):18. doi: https://doi.org/10.1167/iovs.62.10.18

Includes: Supplemental Content

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Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1 + Macrophage Infiltration

USP10 Promotes Fibronectin Recycling, Secretion, and Organization

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

Integrating Clinical Data and Tear Proteomics to Assess Efficacy, Ocular Surface Status, and Biomarker Response After Orthokeratology Lens Wear

Spatially Resolved Proteomic Analysis of the Lens Extracellular Diffusion Barrier

Effects of Aging on Human Meibum

CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X 7 in the Diabetic Retina

Novel Insights Into Muscarinic and Purinergic Responses in Primary Cultures of Rat Lacrimal Gland Myoepithelial Cells

The Potential Role of Osteopontin in the Pathogenesis of Graves’ Ophthalmopathy

The Role of the Wnt Pathway in VEGF/Anti-VEGF-Dependent Control of the Endothelial Cell Barrier

Local and global context repetitions in contextual cueing

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes

Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10

Exploring the Mechanism of the miRNA-145/Paxillin Axis in Cell Metabolism During VEGF-A–Induced Corneal Angiogenesis

Comparison of Syringes With Intravitreal Anti-VEGF Drugs: Particle Burden and Protein Aggregates in Brolucizumab, Aflibercept and Bevacizumab

Analysis of the Aqueous Humor Proteome in Patients With Age-Related Macular Degeneration

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