Biochemistry and Molecular Biology

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Biochemistry and Molecular Biology June 2017

Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

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Elisabetta De Filippo; Prashiela Manga; Anke C. Schiedel
TAGS: albinism, ocular, arrestin, chinese hamster ovary cell, ethacridine, lactates, levodopa, ligands, melanins, melanocyte, monophenol monooxygenase, niclosamide, pimozide, pharmacology, proteins, g-protein-coupled receptors, x-linked inheritance, screening, lysate
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3118-3126. doi: 10.1167/iovs.16-21128

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2017

The Urokinase Receptor-Derived Peptide UPARANT Recovers Dysfunctional Electroretinogram and Blood–Retinal Barrier Leakage in a Rat Model of Diabetes

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Maurizio Cammalleri; Filippo Locri; Stefania Marsili; Massimo Dal Monte; Claudio Pisano; Angelo Mancinelli; Liliana Lista; Dario Rusciano; Mario De Rosa; Vincenzo Pavone; Paola Bagnoli
TAGS: diabetes mellitus, urokinase, blood-retinal barrier, electroretinography, peptides, eye, rats, retina
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3138-3148. doi: 10.1167/iovs.17-21593

Includes: Supplemental Content

Retinal Cell Biology June 2017

Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane

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Astrid Zayas-Santiago; Samuel D. Cross; James B. Stanton; Alan D. Marmorstein; Lihua Y. Marmorstein
TAGS: diffusion, bruch's basal membrane, proteoglycan, mice, fibulin
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3046-3054. doi: 10.1167/iovs.17-21720

Cornea June 2017

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

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Jing Li; Szu-Yu Chen; Xin-Yue Zhao; Ming-Chang Zhang; Hua-Tao Xie
TAGS: signal transduction, western blotting, stem cells, epithelium, ligands, cornea, notch signaling pathway, dual antiplatelet therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2968-2976. doi: 10.1167/iovs.16-20642

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2017

Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

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Karl David Brown; Manisha H. Shah; Guei-Sheung Liu; Elsa C. Chan; Jonathan G. Crowston; Hitesh M. Peshavariya
TAGS: fibroblast, collagen, curcumin, hydrogen peroxide, nadp, protein isoforms, transforming growth factors, conjunctiva, oxidase, collagen synthesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3011-3017. doi: 10.1167/iovs.16-20633

Includes: Supplemental Content

Article June 2017

Training enhances attentional expertise, but not attentional capacity: Evidence from content-specific training benefits

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Roger W. Strong; George A. Alvarez
TAGS: motion, training
Journal of Vision. 2017; 17(4):4. doi: 10.1167/17.4.4

Includes: Supplemental Content

Article June 2017

Central and peripheral vision for scene recognition: A neurocomputational modeling exploration

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Panqu Wang; Garrison W. Cottrell
TAGS: scotoma, vision, peripheral vision
Journal of Vision. 2017; 17(4):9. doi: 10.1167/17.4.9

Physiology and Pharmacology June 2017

VEGF as a Paracrine Regulator of Conventional Outflow Facility

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Ester Reina-Torres; Joanne C. Wen; Katy C. Liu; Guorong Li; Joseph M. Sherwood; Jason Y. H. Chang; Pratap Challa; Cassandra M. Flügel-Koch; W. Daniel Stamer; R. Rand Allingham; Darryl R. Overby
TAGS: vascular endothelial growth factor a, vascular endothelial growth factor receptor-2, paracrine
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1899-1908. doi: 10.1167/iovs.16-20779

Includes: Supplemental Content

Glaucoma June 2017

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner

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Sally Miller; Sherry Shu-Jung Hu; Emma Leishman; Dan Morgan; Jim Wager-Miller; Ken Mackie; Heather B. Bradshaw; Alex Straiker
TAGS: signal transduction, eye, intraocular pressure, lipids, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2930-2938. doi: 10.1167/iovs.16-21330

Includes: Supplemental Content

Cornea June 2017

SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal

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Xiling Zheng; Huixia Cui; Yuanyuan Yin; Yajing Zhang; Rongrong Zong; Xiaorui Bao; Jian-xing Ma; Zuguo Liu; Yueping Zhou
TAGS: antioxidants, western blotting, oxidants, wounds and injuries, cornea
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2874-2883. doi: 10.1167/iovs.17-21544

Glaucoma June 2017

Comparison of MicroRNA Expression in Aqueous Humor of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study

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Hari Jayaram; Jay I. Phillips; Diana C. Lozano; Tiffany E. Choe; William O. Cepurna; Elaine C. Johnson; John C. Morrison; Devin M. Gattey; Julie A. Saugstad; Kate E. Keller
TAGS: polymerase chain reaction, hypertension, open-angle glaucoma, pilot projects, aqueous humor, micro rna
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2884-2890. doi: 10.1167/iovs.17-21844

Includes: Supplemental Content

Review May 2017

CRISPR-Cas Genome Surgery in Ophthalmology

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James E. DiCarlo; Jesse D. Sengillo; Sally Justus; Thiago Cabral; Stephen H. Tsang; Vinit B. Mahajan
TAGS: genome, ophthalmology, surgical procedures, operative, eye, surgery specialty, crispr
Trans. Vis. Sci. Tech.. 2017; 6(3):13. doi: 10.1167/tvst.6.3.13

Biochemistry and Molecular Biology May 2017

A Novel Dominant Mutation in SAG , the Arrestin-1 Gene, Is a Common Cause of Retinitis Pigmentosa in Hispanic Families in the Southwestern United States

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Lori S. Sullivan; Sara J. Bowne; Daniel C. Koboldt; Elizabeth L. Cadena; John R. Heckenlively; Kari E. Branham; Dianna H. Wheaton; Kaylie D. Jones; Richard S. Ruiz; Mark E. Pennesi; Paul Yang; David Davis-Boozer; Hope Northrup; Vsevold V. Gurevich; Rui Chen; Mingchu Xu; Yumei Li; David G. Birch; Stephen P. Daiger
TAGS: mutation, arrestin, family, genes, hispanics or latinos, retinitis pigmentosa
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2774-2784. doi: 10.1167/iovs.16-21341

Physiology and Pharmacology May 2017

Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells

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Dorette Z. Ellis; Linya Li; Yong Park; Shaoqing He; Brett Mueller; Thomas Yorio
TAGS: oxygen, mitochondria, glucose, cytochrome c oxidase, pentazocine, retinal ganglion cells, protein overexpression, caspase-3
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2755-2764. doi: 10.1167/iovs.16-19199

Retinal Cell Biology May 2017

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose–Induced Apoptosis

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Dongjoon Kim; Robert P. Mecham; Philip C. Trackman; Sayon Roy
TAGS: apoptosis, diabetes mellitus, endothelial cells, glucose, aminopropionitrile, down-regulation, protein-lysine 6-oxidase, retina, rna, small interfering, protein overexpression, proto-oncogene proteins c-akt, caspase-3
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2725-2731. doi: 10.1167/iovs.16-21340

Special Issue May 2017

Omics Biomarkers in Ophthalmology

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Susette Lauwen; Eiko K. de Jong; Dirk J. Lefeber; Anneke I. den Hollander
TAGS: glaucoma, biological markers, eye diseases, genome, myopia, ophthalmology, genetics, proteins
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO88-BIO98. doi: 10.1167/iovs.17-21809

Includes: Supplemental Content

Lens May 2017

Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis

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Jeremy A. Whitson; Xiang Zhang; Mario Medvedovic; Jenny Chen; Zongbo Wei; Vincent M. Monnier; Xingjun Fan
TAGS: signal transduction, genes, lens, crystalline, lens (device), epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2666-2684. doi: 10.1167/iovs.16-21398

Includes: Supplemental Content

Retina May 2017

Retinal Vascular Branching in Healthy and Diabetic Subjects

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Ting Luo; Thomas J. Gast; Tyler J. Vermeer; Stephen A. Burns
TAGS: diabetes mellitus, parent, diagnostic imaging, statutes and laws, daughter, diameter
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2685-2694. doi: 10.1167/iovs.17-21653

Includes: Multimedia, Supplemental Content

Cornea May 2017

Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse

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Lixing W. Reneker; Lanlan Wang; Rebecca T. Irlmeier; Andrew J. W. Huang
TAGS: homeostasis, adult, atrophy, meibomian gland, fibroblast growth factor receptors, mice, fgfr2 gene
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2638-2646. doi: 10.1167/iovs.16-21204

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2017

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy

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JaeSang Ko; Min Kyoung Chae; Joon H. Lee; Eun Jig Lee; Jin Sook Yoon
TAGS: western blotting, fibroblast, fibrosis, proteins, sphingosine-1-phosphate phosphatase
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2544-2553. doi: 10.1167/iovs.16-20684

Includes: Supplemental Content

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Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

The Urokinase Receptor-Derived Peptide UPARANT Recovers Dysfunctional Electroretinogram and Blood–Retinal Barrier Leakage in a Rat Model of Diabetes

Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

Training enhances attentional expertise, but not attentional capacity: Evidence from content-specific training benefits

Central and peripheral vision for scene recognition: A neurocomputational modeling exploration

VEGF as a Paracrine Regulator of Conventional Outflow Facility

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner

SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal

Comparison of MicroRNA Expression in Aqueous Humor of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study

CRISPR-Cas Genome Surgery in Ophthalmology

A Novel Dominant Mutation in SAG , the Arrestin-1 Gene, Is a Common Cause of Retinitis Pigmentosa in Hispanic Families in the Southwestern United States

Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose–Induced Apoptosis

Omics Biomarkers in Ophthalmology

Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis

Retinal Vascular Branching in Healthy and Diabetic Subjects

Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy

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