Biochemistry and Molecular Biology

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Biochemistry and Molecular Biology November 2019

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

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Minhong Xiang; Lijuan Mo; Yueping Zhan; Hang Wen; Huanming Zhou; Wanhong Miao
TAGS: cell aging, conjunctivochalasis, fibroblasts, signal transduction, mitogen-activated protein kinases, conjunctiva, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4643-4651. doi: https://doi.org/10.1167/iovs.19-27617

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2019

Characterization of LSD1 Expression Within the Murine Eye

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Salma Ferdous; Hans E. Grossniklaus; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4619-4631. doi: https://doi.org/10.1167/iovs.19-26728

Includes: Supplemental Content

Glaucoma November 2019

Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells

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Ying Ying Sun; John M. Bradley; Kate E. Keller
TAGS: actins, glaucoma, immunohistochemistry, phenotype, trabecular meshwork, transfer technique, vesicle, body tissue, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4583-4595. doi: https://doi.org/10.1167/iovs.19-28084

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology November 2019

Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration

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Nana Xu; Qiyu Bo; Rong Shao; Jian Liang; Yuanqi Zhai; Shiqi Yang; Fenghua Wang; Xiaodong Sun
TAGS: chitinase-3-like protein 1, choroidal neovascularization, macrophages, angiogenesis, exudative age-related macular degeneration, chitinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4596-4605. doi: https://doi.org/10.1167/iovs.19-27493

Includes: Supplemental Content

Articles November 2019

Physicochemical Properties of Hyaluronic Acid–Based Lubricant Eye Drops

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Pasquale Aragona; Peter A. Simmons; Hongpeng Wang; Tao Wang
TAGS: hyaluronic acid, mass or substance concentration per volume, ocular lubricants, viscosity, sodium, osmolality
Trans. Vis. Sci. Tech.. 2019; 8(6):2. doi: https://doi.org/10.1167/tvst.8.6.2

Retinal Cell Biology November 2019

Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by Notch/PTEN/Akt Signaling

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Thomas Fleming; Jerusa E. Balderas-Márquez; David Epardo; José Ávila-Mendoza; Martha Carranza; Maricela Luna; Steve Harvey; Carlos Arámburo; Carlos G. Martínez-Moreno
TAGS: excitotoxicity, neuroprotection, notch1 gene, proto-oncogene proteins c-akt, pten gene, retina, signal transduction, somatotropin, somatropin, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4532-4547. doi: https://doi.org/10.1167/iovs.19-27473

Includes: Supplemental Content

Articles October 2019

Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood–Retinal Barrier Integrity In Vitro

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Marina Mesquida; Faye Drawnel; Philippa J. Lait; David A. Copland; Madeleine L. Stimpson; Victor Llorenç; Maite Sainz de la Maza; Alfredo Adan; Gabriella Widmer; Pamela Strassburger; Sascha Fauser; Andrew D. Dick; Richard W. J. Lee; Blanca Molins
TAGS: interleukin 6 receptor, interleukin-6, macular edema, personal integrity, blood-retinal barrier
Trans. Vis. Sci. Tech.. 2019; 8(5):32. doi: https://doi.org/10.1167/tvst.8.5.32

Includes: Supplemental Content

Retinal Cell Biology October 2019

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration

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Miyuki Murata; Kousuke Noda; Shiho Yoshida; Michiyuki Saito; Akio Fujiya; Atsuhiro Kanda; Susumu Ishida
TAGS: acrolein, chemokine (c-x-c motif) ligand 1, neuroglia, aldehydes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4425-4435. doi: https://doi.org/10.1167/iovs.19-27346

Includes: Supplemental Content

Cornea October 2019

Three-Dimensional Neurite Characterization of Small Incision Lenticule Extraction Derived Lenticules

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Francisco Bandeira; Gary Hin-Fai Yam; Yu-Chi Liu; Kavya Devarajan; Jodhbir S. Mehta
TAGS: neurites
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4408-4415. doi: https://doi.org/10.1167/iovs.19-27566

Includes: Multimedia, Supplemental Content

Retinal Cell Biology October 2019

Creatine is Neuroprotective to Retinal Neurons In Vitro But Not In Vivo

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Paul Ikgan Sia; John P. M. Wood; Glyn Chidlow; Robert Casson
TAGS: creatine
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4360-4377. doi: https://doi.org/10.1167/iovs.18-25858

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2019

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

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Collynn F. Woeller; Elisa Roztocil; Christine Hammond; Steven E. Feldon
TAGS: micrornas, phosphoinositide 3-kinase, proto-oncogene proteins c-akt, signal transduction, thyrotropin, thyrotropin receptor, fibroblasts, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4336-4345. doi: https://doi.org/10.1167/iovs.19-27865

Retina October 2019

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway

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Chufeng Gu; Deji Draga; Chuandi Zhou; Tong Su; Chen Zou; Qing Gu; Tashi Lahm; Zhi Zheng; Qinghua Qiu
TAGS: diabetic retinopathy, nadph oxidase 4, pyroptosis, caspase-1, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4215-4223. doi: https://doi.org/10.1167/iovs.19-27825

Includes: Supplemental Content

Article October 2019

Luminance-contrast properties of texture-shape and texture-surround suppression of contour shape

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Elena Gheorghiu; Frederick A. A. Kingdom
TAGS: luminance, perceptual aftereffect, polarity, shape
Journal of Vision. 2019; 19(12):4. doi: https://doi.org/10.1167/19.12.4

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology October 2019

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

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Chandrani Chattopadhyay; Junna Oba; Jason Roszik; Joseph R. Marszalek; Ken Chen; Yuan Qi; Karina Eterovic; A. Gordon Robertson; Jared K. Burks; Tara A. McCannel; Elizabeth A. Grimm; Scott E. Woodman
TAGS: genes, intraocular melanoma, metabolism, neoplasms, sdha gene, cancer, cell lines, monosomy, mitomycin, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4187-4195. doi: https://doi.org/10.1167/iovs.19-28082

Includes: Supplemental Content

Physiology and Pharmacology October 2019

Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow

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Evan A. Thackaberry; Yi Zhou; Christina L. Zuch de Zafra; Germaine Fuh; Chingwei V. Lee; Sarah Sanowar; John B. Ridgway; Aija M. Kusi; Cindy Farman; Helen Booler; Daniel Sheinson; Carol A. Rasmussen; Paul E. Miller; Eric Wakshull; Minhong Yan; Vladimir Bantseev
TAGS: antibodies, anti-vascular endothelial growth factor therapy, aqueous humor, eye, glaucoma, intraocular pressure, macaca fascicularis, primates, signal transduction, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4097-4108. doi: https://doi.org/10.1167/iovs.18-26349

Biochemistry and Molecular Biology October 2019

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

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Jihei Sara Lee; Jinjoo Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: curcumin, fibroblasts, polyphenols, plants
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4129-4140. doi: https://doi.org/10.1167/iovs.19-27376

Visual Neuroscience September 2019

Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells

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Johnnie M. Moore-Dotson; Erika D. Eggers
TAGS: amacrine cells, diabetes mellitus, gamma-aminobutyric acid, retinal bipolar cells, rod photoreceptors, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4063-4073. doi: https://doi.org/10.1167/iovs.19-27137

Genetics September 2019

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

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Andrea R. Waksmunski; Michelle Grunin; Tyler G. Kinzy; Robert P. Igo, Jr; Jonathan L. Haines; Jessica N. Cooke Bailey; for the International Age-Related Macular Degeneration Genomics Consortium
TAGS: age-related macular degeneration, candidate disease gene, genes, genome, genome-wide association study, ophthalmology, universities, schools, medical, proteins, genetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4041-4051. doi: https://doi.org/10.1167/iovs.19-27827

Includes: Supplemental Content

Glaucoma September 2019

Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner

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Mark S. Filla; Jennifer A. Faralli; Harini Desikan; Jennifer L. Peotter; Abigail C. Wannow; Donna M. Peters
TAGS: fibril, fibronectins, integrins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3897-3913. doi: https://doi.org/10.1167/iovs.19-27171

Includes: Supplemental Content

Lens September 2019

Lens Connexin Channels Have Differential Permeability to the Second Messenger cAMP

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Virginijus Valiunas; Peter R. Brink; Thomas W. White
TAGS: cyclic amp, gap junction protein, lens (device), permeability, lens, crystalline, connexin 43, second messenger systems
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3821-3829. doi: https://doi.org/10.1167/iovs.19-27302

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P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

Characterization of LSD1 Expression Within the Murine Eye

Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells

Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration

Physicochemical Properties of Hyaluronic Acid–Based Lubricant Eye Drops

Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by Notch/PTEN/Akt Signaling

Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood–Retinal Barrier Integrity In Vitro

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration

Three-Dimensional Neurite Characterization of Small Incision Lenticule Extraction Derived Lenticules

Creatine is Neuroprotective to Retinal Neurons In Vitro But Not In Vivo

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway

Luminance-contrast properties of texture-shape and texture-surround suppression of contour shape

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner

Lens Connexin Channels Have Differential Permeability to the Second Messenger cAMP

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