Biochemistry and Molecular Biology

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Cornea & External Disease December 2022

Proteomic Analysis of Meibomian Gland Secretions in Patients With Blepharokeratoconjunctivitis

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Jingjing Su; Hongwei Li; Baotao Lin; Shuiming Li; Xiaoping Zhou; Wei Li; Ping Guo
TAGS: bodily secretions, meibomian gland, proteins, proteomics, signs and symptoms
Trans. Vis. Sci. Tech.. 2022; 11(12):4. doi: https://doi.org/10.1167/tvst.11.12.4

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2022

An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration

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Robyn M. Biggs; Elisavet Makou; Scott Lauder; Andrew P. Herbert; Paul N. Barlow; Suresh K. Katti
TAGS: age-related macular degeneration, complement factor h, complement system proteins, hemolysis, proteins, immunoassay
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):30. doi: https://doi.org/10.1167/iovs.63.12.30

Includes: Supplemental Content

Retina November 2022

Characterization of Retinal Development in 13-Lined Ground Squirrels

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Sangeetha Kandoi; Cassandra Martinez; Dana K. Merriman; Deepak A. Lamba
TAGS: adult, eye, ganglia, retina, retinal cone, photoreceptors, embryo, neuroglia, polymerase chain reaction, retinal bipolar cells
Trans. Vis. Sci. Tech.. 2022; 11(11):17. doi: https://doi.org/10.1167/tvst.11.11.17

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit November 2022

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

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John P. M. Wood; Glyn Chidlow; Luke A. Halliday; Robert J. Casson; Dinesh Selva; Michelle Sun
TAGS: body tissue, langer-giedion syndrome, engineering
Trans. Vis. Sci. Tech.. 2022; 11(11):10. doi: https://doi.org/10.1167/tvst.11.11.10

Includes: Supplemental Content

Glaucoma November 2022

YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction

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Haiyan Li; Ayushi Singh; Kristin M. Perkumas; W. Daniel Stamer; Preethi S. Ganapathy; Samuel Herberg
TAGS: actins, cytoskeleton, hydrogel, hydrogels, pathophysiology, schlemm's canal, glaucoma, actomyosin, fibronectins, stress fibers
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):15. doi: https://doi.org/10.1167/iovs.63.12.15

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2022

Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin

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Yong Lin; Qi Liu; Li Li; Rusen Yang; Juxiu Ye; Shuai Yang; Guangying Luo; Peter S. Reinach; Dongsheng Yan
TAGS: cornea, epithelium, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):14. doi: https://doi.org/10.1167/iovs.63.12.14

Includes: Supplemental Content

Lens November 2022

Changes in the Lipid Profile of Aqueous Humor From Diabetic Cataract Patients

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Jiawei Wang; Ying Zhang; Wanna Li; Fang Zhou; Jianqiao Li
TAGS: diabetic cataract, fasting lipid profile, hypertension, lipids, aqueous humor, diabetes mellitus
Trans. Vis. Sci. Tech.. 2022; 11(11):5. doi: https://doi.org/10.1167/tvst.11.11.5

Telemedicine November 2022

Comparing the Rise in Glucose Concentration in Blood, Aqueous and Interstitial Fluid During a Glucose Tolerance Test

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Tina I. L. Chan; Yolanda W. Y. Yip; Tony T. C. Man; Chi Pui Pang; Mårten Erik Brelén
TAGS: glucose, interstitial fluid, mass or substance concentration per volume, glucose tolerance test
Trans. Vis. Sci. Tech.. 2022; 11(11):3. doi: https://doi.org/10.1167/tvst.11.11.3

Glaucoma November 2022

Pregabalin Mediates Retinal Ganglion Cell Survival From Retinal Ischemia/Reperfusion Injury Via the Akt/GSK3β/β-Catenin Signaling Pathway

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Jing Xu; Yuyan Guo; Qiong Liu; Hui Yang; Ming Ma; Jian Yu; Linjiang Chen; Chunlian Ou; Xiaohui Liu; Jing Wu
TAGS: pregabalin, proto-oncogene proteins c-akt, retinal ischemia, wounds and injuries, signal pathway, signal transduction pathways, reperfusion injury, retinal ganglion cells, neuroprotective effect, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):7. doi: https://doi.org/10.1167/iovs.63.12.7

Includes: Supplemental Content

Genetics November 2022

Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure

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Elangovan Boobalan; Amy H. Thompson; Ramakrishna P. Alur; David M. McGaughey; Lijin Dong; Grace Shih; Emile R. Vieta-Ferrer; Ighovie F. Onojafe; Vijay K. Kalaskar; Gavin Arno; Andrew J. Lotery; Bin Guan; Chelsea Bender; Omar Memon; Lauren Brinster; Clement Soleilhavoup; Lia Panman; Tudor C. Badea; Andrea Minella; Antonio Jacobo Lopez; Sara M. Thomasy; Ala Moshiri; Delphine Blain; Robert B. Hufnagel; Tiziana Cogliati; Kapil Bharti; Brian P. Brooks
TAGS: embryo, fissure, mice, optics, eye, transcription factor
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):5. doi: https://doi.org/10.1167/iovs.63.12.5

Includes: Supplemental Content

Glaucoma November 2022

Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma

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Kristen M. Pitts; Cameron E. Neeson; Nathan E. Hall; Jonathan B. Lin; Henisk K. Falah; Silas L. Wang; Kristine T. Lo; Christian E. Song; Milica A. Margeta; David A. Solá-Del Valle
TAGS: apolipoprotein e, eye, galectin 3, glaucoma, nerve degeneration, aqueous humor, hypertension
Trans. Vis. Sci. Tech.. 2022; 11(11):1. doi: https://doi.org/10.1167/tvst.11.11.1

Biochemistry and Molecular Biology November 2022

Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization

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Zhao Zhang; Megan M. Shen; Yingbin Fu
TAGS: anti-vascular endothelial growth factor therapy, choroidal neovascularization, mice, aflibercept, apolipoprotein a-i, lasers
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):2. doi: https://doi.org/10.1167/iovs.63.12.2

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2022

Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes

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Esma I. Yerlikaya; Allyson L. Toro; Siddharth Sunilkumar; Ashley M. VanCleave; Ming Leung; Yuka Imamura Kawasawa; Scot R. Kimball; Michael D. Dennis
TAGS: cytokine, diabetes mellitus, diabetes mellitus, type 2, syk kinase, vascular endothelial growth factor a, mice, hypoxia, neuroglia, retina, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):25. doi: https://doi.org/10.1167/iovs.63.11.25

Includes: Supplemental Content

Retina October 2022

Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies

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David D. Boyer; Ya-Ping Ko; Steven D. Podos; Mark E. Cartwright; Xiang Gao; Jason A. Wiles; Mingjun Huang
TAGS: body tissue, complement factor d, melanins, oryctolagus cuniculus, pre-clinical research, drug or chemical tissue distribution, plasma, rats, albinism
Trans. Vis. Sci. Tech.. 2022; 11(10):37. doi: https://doi.org/10.1167/tvst.11.10.37

Glaucoma October 2022

Repurposing Antihypertensive Drugs for the Prevention of Glaucoma: A Mendelian Randomization Study

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Jingjing Liu; Shuang Li; Yang Hu; Shizheng Qiu
TAGS: antihypertensive agents, glaucoma, mendelian randomization analysis, prevention, intraocular pressure, blood pressure, genetics
Trans. Vis. Sci. Tech.. 2022; 11(10):32. doi: https://doi.org/10.1167/tvst.11.10.32

Includes: Supplemental Content

Retina October 2022

Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema

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Nicholas J. Agard; Gu Zhang; John Ridgeway; Danielle M. Dicara; Phillip Y. Chu; Rachana Ohri; Sarah Sanowar; Jean-Michel Vernes; Hannah Chi; Jiameng Zhang; Emily Holz; Maciej Paluch; Guannan He; Yingjia Benson; Jianhuan Zhang; Pamela Chan; Nga Tang; Prachi Javale; Blair Wilson; Kathy Barrett; Rebecca K. Rowntree; Julie Hang; Y. Gloria Meng; Phil Hass; Germaine Fuh; Robert Piskol; Vladimir Bantseev; Kelly M. Loyet; John C. Tran; Cong Wu; Vahan B. Indjeian; Vittal Shivva; Minhong Yan
TAGS: agonists, diabetic macular edema, vasculature, antibodies
Trans. Vis. Sci. Tech.. 2022; 11(10):27. doi: https://doi.org/10.1167/tvst.11.10.27

Includes: Supplemental Content

Glaucoma October 2022

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

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Alireza Karimi; Reza Razaghi; Seyed Mohammadali Rahmati; Christopher A. Girkin; J. Crawford Downs
TAGS: biomechanics, cerebrospinal fluid pressure, cribriform plate, donors, eye, intraocular pressure, nerve tissue, optic disk, posture, sclera
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):14. doi: https://doi.org/10.1167/iovs.63.11.14

Includes: Multimedia, Supplemental Content

Anatomy and Pathology/Oncology October 2022

Enhanced Apoptosis in Choroidal Tissues in Lens-Induced Myopia Guinea Pigs by Activating the RASA1 Signaling Pathway

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Jinpeng Liu; Huixia Wei; Zhaohui Yang; Yixian Hao; Guimin Wang; Tuling Li; Ting Yu; Huiping Liao; Bo Bao; Qiuxin Wu; Hongsheng Bi; Dadong Guo
TAGS: apoptosis, body tissue, caviidae, lens (device), lens, crystalline, myopia, signal pathway, signal transduction, signal transduction pathways, bcl2 gene
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):5. doi: https://doi.org/10.1167/iovs.63.11.5

Includes: Supplemental Content

Cornea October 2022

TGF-β–Mediated Modulation of Cell–Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells

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Kim Santerre; Sergio Cortez Ghio; Stéphanie Proulx
TAGS: chronic exertional compartment syndrome, cornea, endothelial cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):3. doi: https://doi.org/10.1167/iovs.63.11.3

Includes: Supplemental Content

Cornea October 2022

Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani -Induced Keratitis via the NF-κB Signaling Pathway

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Hanfeng Tang; Liwei Huang; Jianzhang Hu
TAGS: acute erythroblastic leukemia, cornea, fungal keratitis, fusarium solani, inflammation, inflammatory response, keratitis, methyltransferase, mice, signal pathway
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):2. doi: https://doi.org/10.1167/iovs.63.11.2

Includes: Supplemental Content

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Proteomic Analysis of Meibomian Gland Secretions in Patients With Blepharokeratoconjunctivitis

An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration

Characterization of Retinal Development in 13-Lined Ground Squirrels

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction

Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin

Changes in the Lipid Profile of Aqueous Humor From Diabetic Cataract Patients

Comparing the Rise in Glucose Concentration in Blood, Aqueous and Interstitial Fluid During a Glucose Tolerance Test

Pregabalin Mediates Retinal Ganglion Cell Survival From Retinal Ischemia/Reperfusion Injury Via the Akt/GSK3β/β-Catenin Signaling Pathway

Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure

Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma

Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization

Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes

Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies

Repurposing Antihypertensive Drugs for the Prevention of Glaucoma: A Mendelian Randomization Study

Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Enhanced Apoptosis in Choroidal Tissues in Lens-Induced Myopia Guinea Pigs by Activating the RASA1 Signaling Pathway

TGF-β–Mediated Modulation of Cell–Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells

Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani -Induced Keratitis via the NF-κB Signaling Pathway

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