Biochemistry and Molecular Biology

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Retinal Cell Biology December 2019

A New Zebrafish Model for CACNA2D4-Dysfunction

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Domino K. Schlegel; Stella M. K. Glasauer; José M. Mateos; Gery Barmettler; Urs Ziegler; Stephan C. F. Neuhauss
TAGS: pathophysiology, zebrafish, electroretinography, photoreceptors, synapses
Invest. Ophthalmol. Vis. Sci.. 2019; 60(15):5124-5135. doi: https://doi.org/10.1167/iovs.19-26759

Includes: Supplemental Content

Article December 2019

Agent identity drives adaptive encoding of biological motion into working memory

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Quan Gu; Wenmin Li; Xiqian Lu; Hui Chen; Mowei Shen; Zaifeng Gao
TAGS: color, memory, memory, short-term, metallic stents, motion, reaction time
Journal of Vision. 2019; 19(14):6. doi: https://doi.org/10.1167/19.14.6

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2019

Changes in Human Tear Proteome Following Topical Treatment of Dry Eye Disease: Cyclosporine A Versus Diquafosol Tetrasodium

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Yong Woo Ji; Hye Min Kim; Sun Young Ryu; Jae Won Oh; Areum Yeo; Chul Young Choi; Myoung Joon Kim; Jong Suk Song; Hyun Seung Kim; Kyoung Yul Seo; Kwang Pyo Kim; Hyung Keun Lee
TAGS: cyclosporine, dry eye syndromes, proteins, proteome, proteomics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(15):5035-5044. doi: https://doi.org/10.1167/iovs.19-27872

Includes: Supplemental Content

Article November 2019

Modeling stochastic resonance in humans: The influence of lapse rate

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Jeroen J. A. van Boxtel
TAGS: noise, vibration, signal detection (psychology)
Journal of Vision. 2019; 19(13):19. doi: https://doi.org/10.1167/19.13.19

Genetics November 2019

Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease

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Jian Qi; Liping Du; Jing Deng; Yang Qin; Guannan Su; Shengping Hou; Meng Lv; Qi Zhang; Aize Kijlstra; Peizeng Yang
TAGS: cytokine, disease susceptibility, genome-wide association study, genotype, rna, messenger, rna, untranslated, single nucleotide polymorphism, uveomeningoencephalitic syndrome, chief complaint
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4820-4829. doi: https://doi.org/10.1167/iovs.19-27708

Retina November 2019

Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the Montrachet Study)

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Pierre-Henry Gabrielle; Alassane Seydou; Louis Arnould; Niyazi Acar; Hervé Devilliers; Florian Baudin; Ines Ben Ghezala; Christine Binquet; Alain Marie Bron; Catherine Creuzot-Garcher
TAGS: digestive tract decontamination, elderly, eye, spectral-domain optical coherence tomography, prevalence, color, fundus photography, age-related macular degeneration, diagnostic imaging, antilipemic agents
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4838-4848. doi: https://doi.org/10.1167/iovs.19-27283

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2019

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

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Hun Lee; Hana Jeong; Chang Mok Lee; Jin-A Shin; Sung-Wuk Jang; Jae Hyuck Lee; So Young Park; Jae Yong Kim; Hungwon Tchah
TAGS: fibroblasts, hpfs trial, mitomycin, pterygium, cell motility, recurrence
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4784-4791. doi: https://doi.org/10.1167/iovs.19-27153

Anatomy and Pathology/Oncology November 2019

Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma

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Annemijn P. A. Wierenga; Jinfeng Cao; Henk Mouthaan; Christiaan van Weeghel; Robert M. Verdijk; Sjoerd G. van Duinen; Wilma G. M. Kroes; Mehmet Dogrusöz; Marina Marinkovic; Sjoerd S. H. van der Burg; Gregorius P. M. Luyten; Martine J. Jager
TAGS: aqueous humor, biological markers, biopsy, cytokine, intraocular melanoma, neoplasms, patient prognosis, histopathology tests, eye
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4740-4747. doi: https://doi.org/10.1167/iovs.19-28309

Includes: Supplemental Content

Lens November 2019

Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression

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Xiaoran Wang; Bowen Wang; Na Zhao; Chenjie Wang; Mi Huang; Baoxin Chen; Jieping Chen; Yan Sun; Lang Xiong; Shan Huang; Yizhi Liu
TAGS: down-regulation, epithelial to mesenchymal transition, fibrosis, lens (device), lens, crystalline, pharmacology
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4748-4758. doi: https://doi.org/10.1167/iovs.19-27596

Includes: Supplemental Content

Glaucoma November 2019

Lowered Decorin With Aberrant Extracellular Matrix Remodeling in Aqueous Humor and Tenon's Tissue From Primary Glaucoma Patients

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Sampath NikhalaShree; Gayathree Karthikkeyan; Ronnie George; Balekudaru Shantha; Lingam Vijaya; Vineet Ratra; Konerirajapuram Natarajan Sulochana; Karunakaran Coral
TAGS: aqueous humor, body tissue, connective tissue growth factor, extracellular matrix, glaucoma, glaucoma, primary, hypertension, open-angle glaucoma, proteins, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4661-4669. doi: https://doi.org/10.1167/iovs.19-27091

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2019

LncRNA PLCD3-OT1 Functions as a CeRNA to Prevent Age-Related Cataract by Sponging miR-224-5p and Regulating PLCD3 Expression

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Jing Xiang; Qin Chen; Lihua Kang; Guowei Zhang; Yong Wang; Bai Qin; Jian Wu; Tianqiu Zhou; Yongzhao Han; Huaijin Guan
TAGS: apoptosis, cataract, senile, cell cycle, polymerase chain reaction, protein overexpression, proteins, rna, rna, messenger, ultraviolet b radiation, cell survival
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4670-4680. doi: https://doi.org/10.1167/iovs.19-27211

Includes: Supplemental Content

Article November 2019

Expecting the unexpected: Temporal expectation increases the flash-grab effect

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Kate M. Coffey; Nika Adamian; Tessel Blom; Elle van Heusden; Patrick Cavanagh; Hinze Hogendoorn
TAGS: attention, illusions, motion, perception
Journal of Vision. 2019; 19(13):9. doi: https://doi.org/10.1167/19.13.9

Biochemistry and Molecular Biology November 2019

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

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Minhong Xiang; Lijuan Mo; Yueping Zhan; Hang Wen; Huanming Zhou; Wanhong Miao
TAGS: cell aging, conjunctivochalasis, fibroblasts, signal transduction, mitogen-activated protein kinases, conjunctiva, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4643-4651. doi: https://doi.org/10.1167/iovs.19-27617

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2019

Characterization of LSD1 Expression Within the Murine Eye

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Salma Ferdous; Hans E. Grossniklaus; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4619-4631. doi: https://doi.org/10.1167/iovs.19-26728

Includes: Supplemental Content

Glaucoma November 2019

Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells

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Ying Ying Sun; John M. Bradley; Kate E. Keller
TAGS: actins, glaucoma, immunohistochemistry, phenotype, trabecular meshwork, transfer technique, vesicle, body tissue, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4583-4595. doi: https://doi.org/10.1167/iovs.19-28084

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology November 2019

Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration

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Nana Xu; Qiyu Bo; Rong Shao; Jian Liang; Yuanqi Zhai; Shiqi Yang; Fenghua Wang; Xiaodong Sun
TAGS: chitinase-3-like protein 1, choroidal neovascularization, macrophages, angiogenesis, exudative age-related macular degeneration, chitinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4596-4605. doi: https://doi.org/10.1167/iovs.19-27493

Includes: Supplemental Content

Retinal Cell Biology November 2019

Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by Notch/PTEN/Akt Signaling

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Thomas Fleming; Jerusa E. Balderas-Márquez; David Epardo; José Ávila-Mendoza; Martha Carranza; Maricela Luna; Steve Harvey; Carlos Arámburo; Carlos G. Martínez-Moreno
TAGS: excitotoxicity, neuroprotection, notch1 gene, proto-oncogene proteins c-akt, pten gene, retina, signal transduction, somatotropin, somatropin, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4532-4547. doi: https://doi.org/10.1167/iovs.19-27473

Includes: Supplemental Content

Articles November 2019

Physicochemical Properties of Hyaluronic Acid–Based Lubricant Eye Drops

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Pasquale Aragona; Peter A. Simmons; Hongpeng Wang; Tao Wang
TAGS: hyaluronic acid, mass or substance concentration per volume, ocular lubricants, viscosity, sodium, osmolality
Trans. Vis. Sci. Tech.. 2019; 8(6):2. doi: https://doi.org/10.1167/tvst.8.6.2

Articles October 2019

Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood–Retinal Barrier Integrity In Vitro

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Marina Mesquida; Faye Drawnel; Philippa J. Lait; David A. Copland; Madeleine L. Stimpson; Victor Llorenç; Maite Sainz de la Maza; Alfredo Adan; Gabriella Widmer; Pamela Strassburger; Sascha Fauser; Andrew D. Dick; Richard W. J. Lee; Blanca Molins
TAGS: interleukin 6 receptor, interleukin-6, macular edema, personal integrity, blood-retinal barrier
Trans. Vis. Sci. Tech.. 2019; 8(5):32. doi: https://doi.org/10.1167/tvst.8.5.32

Includes: Supplemental Content

Retinal Cell Biology October 2019

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration

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Miyuki Murata; Kousuke Noda; Shiho Yoshida; Michiyuki Saito; Akio Fujiya; Atsuhiro Kanda; Susumu Ishida
TAGS: acrolein, chemokine (c-x-c motif) ligand 1, neuroglia, aldehydes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4425-4435. doi: https://doi.org/10.1167/iovs.19-27346

Includes: Supplemental Content

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A New Zebrafish Model for CACNA2D4-Dysfunction

Agent identity drives adaptive encoding of biological motion into working memory

Changes in Human Tear Proteome Following Topical Treatment of Dry Eye Disease: Cyclosporine A Versus Diquafosol Tetrasodium

Modeling stochastic resonance in humans: The influence of lapse rate

Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease

Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the Montrachet Study)

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma

Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression

Lowered Decorin With Aberrant Extracellular Matrix Remodeling in Aqueous Humor and Tenon's Tissue From Primary Glaucoma Patients

LncRNA PLCD3-OT1 Functions as a CeRNA to Prevent Age-Related Cataract by Sponging miR-224-5p and Regulating PLCD3 Expression

Expecting the unexpected: Temporal expectation increases the flash-grab effect

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

Characterization of LSD1 Expression Within the Murine Eye

Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells

Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration

Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by Notch/PTEN/Akt Signaling

Physicochemical Properties of Hyaluronic Acid–Based Lubricant Eye Drops

Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood–Retinal Barrier Integrity In Vitro

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration

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