Biochemistry and Molecular Biology

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Immunology and Microbiology March 2023

Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization

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Daphne P. C. Vergouwen; Josianne C. Ten Berge; Coskun Guzel; Thierry P. P. van den Bosch; Robert M. Verdijk; Aniki Rothova; Theo M. Luider; Marco W. J. Schreurs
TAGS: filaggrin proteins, flg gene, neovascularization, pathologic, proteins, proteome, sclera, scleritis, up-regulation (physiology), body tissue, histopathology tests
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):27. doi: https://doi.org/10.1167/iovs.64.3.27

Includes: Supplemental Content

Cornea & External Disease March 2023

Noncontact Acoustic Micro-Tapping Optical Coherence Elastography for Quantification of Corneal Anisotropic Elasticity: In Vivo Rabbit Study

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Mitchell A. Kirby; Gabriel Regnault; Ivan Pelivanov; Matthew O'Donnell; Ruikang K. Wang; Tueng T. Shen
TAGS: acoustics, cornea, elasticity imaging techniques, microbiology procedures, oryctolagus cuniculus, elasticity, optics, intraocular pressure
Trans. Vis. Sci. Tech.. 2023; 12(3):15. doi: https://doi.org/10.1167/tvst.12.3.15

Includes: Supplemental Content

Refractive Intervention March 2023

Corneal Biomechanics After SMILE, Femtosecond-Assisted LASIK, and Photorefractive Keratectomy: A Matched Comparison Study

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Hassan Hashemi; Cynthia J. Roberts; Ahmed Elsheikh; Shiva Mehravaran; Parsa Panahi; Soheila Asgari
TAGS: biomechanics, comparative study research, cornea, keratectomy, keratomileusis, laser in situ, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2023; 12(3):12. doi: https://doi.org/10.1167/tvst.12.3.12

Cornea March 2023

Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model

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Yu Chen; Jiheng Pu; Xinda Li; Lili Lian; Chaoxiang Ge; Zuimeng Liu; Weizhuo Wang; Ling Hou; Wei Chen; Jinyang Li
TAGS: corneal epithelium, dry eye syndromes, lacrimal gland, mice, dna, immunohistochemistry, cornea, interleukin-18
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):26. doi: https://doi.org/10.1167/iovs.64.3.26

Includes: Supplemental Content

Editorial March 2023

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin; Roy Chuck
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2023; 12(3):10. doi: https://doi.org/10.1167/tvst.12.3.10

Biochemistry and Molecular Biology March 2023

Missense Mutations in MAB21L1 : Causation of Novel Autosomal Dominant Ocular BAMD Syndrome

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Panfeng Wang; Pengsen Wu; Junwen Wang; Yiyan Zeng; Yi Jiang; Yingwei Wang; Shiqiang Li; Xueshan Xiao; Qingjiong Zhang
TAGS: missense mutation, phenotype, syndrome, family
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):19. doi: https://doi.org/10.1167/iovs.64.3.19

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2023

Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States

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Meghashri Saravanan; Rong Xu; Olivia Roby; Yekai Wang; Siyan Zhu; Amy Lu; Jianhai Du
TAGS: body tissue, brain, eye, metabolism, metabolites, mice, sex characteristics, metabolome, lens, crystalline, retina
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):18. doi: https://doi.org/10.1167/iovs.64.3.18

Includes: Supplemental Content

Lens March 2023

SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation

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Lili Lian; Zhenmin Le; Zhenzhen Wang; Ying-ao Chen; Xiaodong Jiao; Hang Qi; J. Fielding Hejtmancik; Xiaoyin Ma; Qinxiang Zheng; Yueping Ren
TAGS: cataract, glucose, inflammasomes, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):16. doi: https://doi.org/10.1167/iovs.64.3.16

Includes: Supplemental Content

Cornea March 2023

Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty

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Ruixing Liu; Jingguo Li; Zhihua Guo; Dandan Chu; Chengcheng Li; Liuqi Shi; Junjie Zhang; Lei Zhu; Zhanrong Li
TAGS: cornea, descemet stripping endothelial keratoplasty, fibrosis, signal transduction, proteins, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):9. doi: https://doi.org/10.1167/iovs.64.3.9

Biochemistry and Molecular Biology March 2023

Single-Cell Characterization of the Frizzled 5 ( Fz5 ) Mutant Mouse and Human Persistent Fetal Vasculature (PFV)

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Yuanyuan Chen; Cheng Wu; Shanzhen Peng; Dianlei Guo; Hong Ouyang; Yanhong Wei; Rong Ju; Xiaoyan Ding; Zhi Xie; Chunqiao Liu
TAGS: mice, persistent hyperplastic primary vitreous, vitreous body, melanocytes
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):8. doi: https://doi.org/10.1167/iovs.64.3.8

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2023

The RNA m 5 C Methylase NSUN2 Modulates Corneal Epithelial Wound Healing

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Guangying Luo; Weiwei Xu; Xiaoyan Chen; Wenji Xu; Shuai Yang; Jiao Wang; Yong Lin; Peter S. Reinach; Dongsheng Yan
TAGS: rna, methyltransferase, cornea, wound healing, epithelium
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):5. doi: https://doi.org/10.1167/iovs.64.3.5

Includes: Supplemental Content

Retinal Cell Biology March 2023

Clinicopathologic Findings in Three Siblings With Geographic Atrophy

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Malia M. Edwards; D. Scott McLeod; Mengxi Shen; Rhonda Grebe; Janet S. Sunness; Imran A. Bhutto; Erin McDonnell; Alexandra M. Pado; Giovanni Gregori; Philip J. Rosenfeld; Gerard A. Lutty
TAGS: atrophy, drusen, eye, retina, relationship - sibling, choroidal neovascularization, chief complaint, pathology, clinical, donors, atrophic condition of skin
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):2. doi: https://doi.org/10.1167/iovs.64.3.2

Retinal Cell Biology March 2023

Kif5a Regulates Mitochondrial Transport in Developing Retinal Ganglion Cells In Vitro

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Satoshi Yokota; Sahil H. Shah; Emma Lee Huie; Runxia Rain Wen; Ziming Luo; Jeffrey L. Goldberg
TAGS: axonal transport, biological transport, mitochondria, mitochondrial transport, retinal ganglion cells, diagnostic imaging, cell motility
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):4. doi: https://doi.org/10.1167/iovs.64.3.4

Retina February 2023

Macular Edema in Central Retinal Vein Occlusion Correlates With Aqueous Fibrinogen Alpha Chain

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Lasse Jørgensen Cehofski; Kentaro Kojima; Natsuki Kusada; Maja Rasmussen; Danson Vasanthan Muttuvelu; Jakob Grauslund; Henrik Vorum; Bent Honoré
TAGS: central retinal vein occlusion, fga gene, macular edema, proteins, proteome, fibrinogen
Invest. Ophthalmol. Vis. Sci.. 2023; 64(2):23. doi: https://doi.org/10.1167/iovs.64.2.23

Includes: Supplemental Content

Immunology and Microbiology February 2023

Genetic Manipulation of Corynebacterium mastitidis to Better Understand the Ocular Microbiome

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Yannis Rigas; Benjamin R. Treat; Jackie Shane; Robert M. Q. Shanks; Anthony J. St. Leger
TAGS: bacteria, corynebacterium, dna transposons, eye, genes, genetic manipulation, immunity, mice, microbial colonization, microbiome
Invest. Ophthalmol. Vis. Sci.. 2023; 64(2):19. doi: https://doi.org/10.1167/iovs.64.2.19

Cornea & External Disease February 2023

Norepinephrine as an Enhancer Promoting Corneal Penetration of Riboflavin for Transepithelial Corneal Crosslinking

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Guoying Liu; Tan Li; Benxiang Qi; Ganyu Gong; Tengyou Guo; Qingjun Zhou; Vishal Jhanji; Bi Ning Zhang; Xianli Du
TAGS: cornea, corneal collagen cross-linking, norepinephrine, riboflavin, enhancer of transcription
Trans. Vis. Sci. Tech.. 2023; 12(2):21. doi: https://doi.org/10.1167/tvst.12.2.21

Includes: Supplemental Content

Retina February 2023

Beneficial and Detrimental Pressure-Related Effects on Inner Neurons in the Adult Porcine In Vitro Retina

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Frida Svare; Fredrik Ghosh
TAGS: adult, immunohistochemistry, retina, suidae, retinal bipolar cells, neurons, rod photoreceptors, ganglia
Trans. Vis. Sci. Tech.. 2023; 12(2):19. doi: https://doi.org/10.1167/tvst.12.2.19

Immunology and Microbiology February 2023

The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis

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Abdulraouf Ramadan; Zhiyi Cao; Mihaela Gadjeva; Tanweer S. Zaidi; Vijay A. Rathinam; Noorjahan Panjwani
TAGS: inflammasomes, keratitis, nlr family, pyrin domain-containing 3 protein, cornea, pseudomonas, mice, infections
Invest. Ophthalmol. Vis. Sci.. 2023; 64(2):11. doi: https://doi.org/10.1167/iovs.64.2.11

Includes: Supplemental Content

Retina February 2023

Probable Treatment Targets for Diabetic Retinopathy Based on an Integrated Proteomic and Genomic Analysis

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Anddre Osmar Valdivia; Ye He; Xinjun Ren; Dejia Wen; Lijie Dong; Hossein Nazari; Xiaorong Li
TAGS: bioinformatics, datasets, diabetic retinopathy, genome, proteins, proteomics, whole genome sequencing
Trans. Vis. Sci. Tech.. 2023; 12(2):8. doi: https://doi.org/10.1167/tvst.12.2.8

Includes: Supplemental Content

Glaucoma February 2023

The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study

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Babak N. Safa; Adam Bleeker; John P. Berdahl; C. Ross Ethier
TAGS: biomechanics, body tissue, cornea, intraocular pressure, optic disk, computer simulation, eye
Trans. Vis. Sci. Tech.. 2023; 12(2):5. doi: https://doi.org/10.1167/tvst.12.2.5

Includes: Supplemental Content

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Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization

Noncontact Acoustic Micro-Tapping Optical Coherence Elastography for Quantification of Corneal Anisotropic Elasticity: In Vivo Rabbit Study

Corneal Biomechanics After SMILE, Femtosecond-Assisted LASIK, and Photorefractive Keratectomy: A Matched Comparison Study

Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Missense Mutations in MAB21L1 : Causation of Novel Autosomal Dominant Ocular BAMD Syndrome

Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States

SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation

Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty

Single-Cell Characterization of the Frizzled 5 ( Fz5 ) Mutant Mouse and Human Persistent Fetal Vasculature (PFV)

The RNA m 5 C Methylase NSUN2 Modulates Corneal Epithelial Wound Healing

Clinicopathologic Findings in Three Siblings With Geographic Atrophy

Kif5a Regulates Mitochondrial Transport in Developing Retinal Ganglion Cells In Vitro

Macular Edema in Central Retinal Vein Occlusion Correlates With Aqueous Fibrinogen Alpha Chain

Genetic Manipulation of Corynebacterium mastitidis to Better Understand the Ocular Microbiome

Norepinephrine as an Enhancer Promoting Corneal Penetration of Riboflavin for Transepithelial Corneal Crosslinking

Beneficial and Detrimental Pressure-Related Effects on Inner Neurons in the Adult Porcine In Vitro Retina

The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis

Probable Treatment Targets for Diabetic Retinopathy Based on an Integrated Proteomic and Genomic Analysis

The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study

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