Biochemistry and Molecular Biology

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Visual Neuroscience September 2023

A Simplified Model of Activation and Deactivation of Human Rod Phototransduction—An Electroretinographic Study

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James D. Akula; Annie M. Lancos; Bilal K. AlWattar; Hanna De Bruyn; Ronald M. Hansen; Anne B. Fulton
TAGS: phototransduction, rod photoreceptors, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):36. https://doi.org/10.1167/iovs.64.12.36

Includes: Supplemental Content

Cornea September 2023

Alteration of Meibum Lipidomics Profiling in Patients With Chronic Ocular Graft-Versus-Host Disease

PDF

Wenxin Zhao; Jing Yang; Yinglin Liao; Boyu Yang; Shujiao Lin; Ren Liu; Lingyi Liang
TAGS: lipids, graft-versus-host disease, lipidomics
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):35. https://doi.org/10.1167/iovs.64.12.35

Includes: Supplemental Content

Immunology and Microbiology September 2023

Causal Effects of Gut Microbiota on Age-Related Macular Degeneration: A Mendelian Randomization Study

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Deshen Mao; Borui Tao; Shuyan Sheng; Hui Jin; Wenxuan Chen; Huimin Gao; Jianyi Deng; Zhuo Li; Fan Chen; Shixin Chan; Longqi Qian
TAGS: age-related macular degeneration, mendelian randomization analysis, microbiome, sensitivity analysis, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):32. https://doi.org/10.1167/iovs.64.12.32

Includes: Supplemental Content

Visual Neuroscience September 2023

Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice

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Ying Bai; Guohu Di; Huanhuan Ge; Bin Li; Kaier Zhang; Di Zhang; Dianqiang Wang; Peng Chen
TAGS: langer-giedion syndrome, mice, netrin-1, neurons, axon, axon guidance, lacrimal gland
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):27. https://doi.org/10.1167/iovs.64.12.27

Includes: Multimedia, Supplemental Content

Cornea & External Disease September 2023

In Vitro Evaluation of Rose Bengal Photoactivated by Custom-Built Green Light-Emitting Diode Source for Bacteria and Rapidly Growing Mycobacteria Inhibition

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Talita Trevizani Rocchetti; Wirley Alves Mendonça, Jr; Jarbas Caiado de Castro Neto; Lucas Orlandi de Oliveira; André Orlandi de Oliveira; Denise de Freitas; Ana Luisa Höfling-Lima
TAGS: bacteria, rapid-growing mycobacteria, rose bengal
Trans. Vis. Sci. Tech.. 2023; 12(9):9. https://doi.org/10.1167/tvst.12.9.9

Anatomy and Pathology/Oncology September 2023

Mechanisms of Extraorbital Lacrimal Gland Aging in Mice: An Integrative Analysis of the Temporal Transcriptome

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Jiangman Liu; Hongli Si; Duliurui Huang; Dingli Lu; Sen Zou; Di Qi; Xiaoting Pei; Shenzhen Huang; Zhijie Li
TAGS: aging, mice, lacrimal gland
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):18. https://doi.org/10.1167/iovs.64.12.18

Includes: Supplemental Content

Genetics September 2023

TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis

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Hao-Kai Chuang; Ai-Ru Hsieh; Tien-Yap Ang; Szu-Wen Chen; Yi-Ping Yang; Hung-Juei Huang; Shih-Hwa Chiou; Tai-Chi Lin; Shih-Jen Chen; Chih-Chien Hsu; De-Kuang Hwang
TAGS: genetic risk, genome-wide association study, polygenic risk score, polymorphism, retinal detachment, vipr2 gene
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):17. https://doi.org/10.1167/iovs.64.12.17

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2023

Kallistatin Deficiency Induces the Oxidative Stress-Related Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells: A Novel Protagonist in Age-Related Macular Degeneration

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Gang Shen; Yanmei Li; Yongcheng Zeng; Fuyan Hong; Jing Zhang; Yan Wang; Chengwei Zhang; Wei Xiang; Jinhong Wang; Zhenzhen Fang; Weiwei Qi; Xia Yang; Guoquan Gao; Ti Zhou
TAGS: age-related macular degeneration, epithelial to mesenchymal transition, retinal pigment cell, stress, oxidative stress
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):15. https://doi.org/10.1167/iovs.64.12.15

Includes: Supplemental Content

Glaucoma September 2023

Keratin8 Deficiency Aggravates Retinal Ganglion Cell Damage Under Acute Ocular Hypertension

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Chengshou Zhang; Naiji Yu; Qiyu Qin; Xingdi Wu; Yuxiang Gu; Tong Liu; Qi Zhang; Xin Liu; Min Chen; Kaijun Wang
TAGS: glaucoma, ocular hypertension, retina, retinal ganglion cells, symptom aggravating factors, wounds and injuries, apoptosis, mitogen-activated protein kinases, mice, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):1. https://doi.org/10.1167/iovs.64.12.1

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract September 2023

Poster Session: A unifying framework for perceptual decision-making

Ying Lin; Zhen Chen; Jose Reynoso; Ralf Haefner; Duje Tadin
TAGS: decision making, posters
Journal of Vision. 2023; 23(11):59. https://doi.org/10.1167/jov.23.11.59

Optica Fall Vision Meeting Abstract September 2023

Contributed Session II: Detecting subclinical keratoconus by mapping corneal biomechanics using wave-based optical coherence elastography

Fernando Zvietcovich; Judith Birkenfeld; Nicolas Alejandre-Alba; Jesus Merayo; Susana Marcos
TAGS: biomechanics, cornea, elasticity imaging techniques, keratoconus, optics
Journal of Vision. 2023; 23(11):20. https://doi.org/10.1167/jov.23.11.20

Optica Fall Vision Meeting Abstract September 2023

Poster Session: The impact of retinal excitotoxic lesions on parallel visual streams in the ferret dorsal lateral geniculate nucleus.

Jingyi Yang; Krystel Huxlin; Farran Briggs
TAGS: ferrets, lateral geniculate body, posters
Journal of Vision. 2023; 23(11):79. https://doi.org/10.1167/jov.23.11.79

Optica Fall Vision Meeting Abstract September 2023

Poster Session: Optoretinography-based frequency characterization of the retinal response to a chirped flickering light

Piotr Franciszek Wegrzyn; Sławomir Tomczewski; Dawid Borycki; Maciej Wojtkowski; Andrea Curatolo
TAGS: posters
Journal of Vision. 2023; 23(11):76. https://doi.org/10.1167/jov.23.11.76

Retinal Cell Biology August 2023

Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis

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Wenli Yang; Fan Xia; Fang Mei; Shuizhen Shi; William G. Robichaux, III; Wei Lin; Wenbo Zhang; Hua Liu; Xiaodong Cheng
TAGS: apoptosis, blood capillaries, diabetes mellitus, ischemia, mice, mitochondria, pericytes, reactive oxygen species, retinal diseases, retinal vasculature
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):34. https://doi.org/10.1167/iovs.64.11.34

Includes: Supplemental Content

Lens August 2023

Spatially Resolved Proteomics Reveals Lens Suture-Related Cell–Cell Junctional Protein Distributions

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Zhen Wang; Romell B. Gletten; Kevin L. Schey
TAGS: lens (device), lens, crystalline, proteins, proteome, sutures, proteomics, fluorescent antibody technique, gap junction protein
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):28. https://doi.org/10.1167/iovs.64.11.28

Includes: Supplemental Content

Anatomy and Pathology/Oncology August 2023

Identifying Treatment Resistance Related Pathways by Analyzing Serum Extracellular Vesicles of Patients With Resistant Versus Regressed Retinoblastoma

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Radhika Manukonda; Saumya Jakati; Jyothi Attem; Dilip K. Mishra; Tirupathi Rao Mocherla; Mamatha M. Reddy; Khushboo Gulati; Krishna Mohan Poluri; Geeta K. Vemuganti; Swathi Kaliki
TAGS: adult, extracellular vesicles, genes, neoplasms, patient isolation, proteins, retina, retinoblastoma, rna, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):26. https://doi.org/10.1167/iovs.64.11.26

Includes: Supplemental Content

Retinal Cell Biology August 2023

PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy

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Shuizhen Shi; Chun Ding; Shuang Zhu; Fan Xia; Seth E. Buscho; Shengguo Li; Massoud Motamedi; Hua Liu; Wenbo Zhang
TAGS: ischemia, mice, neovascularization, pathologic, neurons, oxygen, perk inhibitor i, retina, retinal diseases, immunohistochemistry, western blotting
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):17. https://doi.org/10.1167/iovs.64.11.17

Cornea & External Disease August 2023

Genetic Correlations Among Corneal Biophysical Parameters and Anthropometric Traits

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Henry C. Cousins; Clara C. Cousins; Girish Valluru; Russ B. Altman; Yutao Liu; Louis R. Pasquale; Sumayya Ahmad
TAGS: biophysics, cornea, genetics, genes, keratoconus
Trans. Vis. Sci. Tech.. 2023; 12(8):8. https://doi.org/10.1167/tvst.12.8.8

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2023

Intrinsic Disorder in the Human Tear Proteome

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David J. Taylor Gonzalez; Mak Djulbegovic; Michael Antonietti; Matthew Cordova; Guy W. Dayhoff, II; Robby Mattes; Anat Galor; Vladimir N. Uversky; Carol L. Karp
TAGS: proteins, proteome
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):14. https://doi.org/10.1167/iovs.64.11.14

Includes: Supplemental Content

Clinical and Epidemiologic Research August 2023

Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1 H NMR Spectroscopy Results From the UK Biobank

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Louis R. Pasquale; Anthony P. Khawaja; Janey L. Wiggs; Jihye Kim; Pirro Hysi; Tobias Elze; Jessica Lasky-Su; Jae H. Kang; Oana Zeleznik; for the UK Biobank Eye and Vision Consortium
TAGS: biobanks, biological markers, intraocular pressure, metabolites, lipids, spectrum analysis
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):11. https://doi.org/10.1167/iovs.64.11.11

Includes: Supplemental Content

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A Simplified Model of Activation and Deactivation of Human Rod Phototransduction—An Electroretinographic Study

Alteration of Meibum Lipidomics Profiling in Patients With Chronic Ocular Graft-Versus-Host Disease

Causal Effects of Gut Microbiota on Age-Related Macular Degeneration: A Mendelian Randomization Study

Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice

In Vitro Evaluation of Rose Bengal Photoactivated by Custom-Built Green Light-Emitting Diode Source for Bacteria and Rapidly Growing Mycobacteria Inhibition

Mechanisms of Extraorbital Lacrimal Gland Aging in Mice: An Integrative Analysis of the Temporal Transcriptome

TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis

Kallistatin Deficiency Induces the Oxidative Stress-Related Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells: A Novel Protagonist in Age-Related Macular Degeneration

Keratin8 Deficiency Aggravates Retinal Ganglion Cell Damage Under Acute Ocular Hypertension

Poster Session: A unifying framework for perceptual decision-making

Contributed Session II: Detecting subclinical keratoconus by mapping corneal biomechanics using wave-based optical coherence elastography

Poster Session: The impact of retinal excitotoxic lesions on parallel visual streams in the ferret dorsal lateral geniculate nucleus.

Poster Session: Optoretinography-based frequency characterization of the retinal response to a chirped flickering light

Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis

Spatially Resolved Proteomics Reveals Lens Suture-Related Cell–Cell Junctional Protein Distributions

Identifying Treatment Resistance Related Pathways by Analyzing Serum Extracellular Vesicles of Patients With Resistant Versus Regressed Retinoblastoma

PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy

Genetic Correlations Among Corneal Biophysical Parameters and Anthropometric Traits

Intrinsic Disorder in the Human Tear Proteome

Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1 H NMR Spectroscopy Results From the UK Biobank

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