Cornea

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Cornea September 2017

Astigmatism and Refractive Outcome After Late In-The-Bag Intraocular Lens Dislocation Surgery: A Randomized Clinical Trial

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Olav Kristianslund; Atle Einar Østern; Liv Drolsum
TAGS: clinical trials, astigmatism, dislocations, postoperative care, surgical procedures, operative, intraocular lens implant device
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4747-4753. doi: 10.1167/iovs.17-22723

Cornea September 2017

Spatiotemporally Controlled Ablation of Klf5 Results in Dysregulated Epithelial Homeostasis in Adult Mouse Corneas

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Chelsea L. Loughner; Anil Tiwari; Doreswamy Kenchegowda; Sudha Swamynathan; Shivalingappa K. Swamynathan
TAGS: epithelium, homeostasis, adult, antibodies, cornea, mice, ablation
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4683-4693. doi: 10.1167/iovs.17-22498

Includes: Supplemental Content

Cornea September 2017

Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration

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Guohu Di; Xia Qi; Xiaowen Zhao; Songmei Zhang; Patrik Danielson; Qingjun Zhou
TAGS: diabetes mellitus, epithelium, corneal epithelium, cornea, mice, glial cell-line derived neurotrophic factor, nerve regeneration, nerve growth factors
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4695-4702. doi: 10.1167/iovs.16-21372

Includes: Supplemental Content

Immunology and Microbiology September 2017

Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection

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Ana J. Chucair-Elliott; Hem R. Gurung; Meghan M. Carr; Daniel J. J. Carr
TAGS: fibrinogen, human herpesvirus 1, macrophage, nerve degeneration, neurons, infection, cornea, mice, proteins, stat3 protein, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4670-4682. doi: 10.1167/iovs.17-22159

Cornea September 2017

Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals

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David L. Williams; Barbara M. Wirostko; Glenwood Gum; Brenda K. Mann
TAGS: ulcer, cats, dog, domestic, hyaluronic acid, hydrogel, oryctolagus cuniculus, wound healing, cornea, corneal epithelial defect, healing process, adaptive testing
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4616-4622. doi: 10.1167/iovs.16-20848

Cornea September 2017

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways

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Marit Lippestad; Robin R. Hodges; Tor P. Utheim; Charles N. Serhan; Darlene A. Dartt
TAGS: bodily secretions, glycoconjugates, goblet cells, mucins, conjunctiva, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4530-4544. doi: 10.1167/iovs.17-21914

Cornea September 2017

Allogeneic Descemet's Membrane Transplantation Enhances Corneal Endothelial Monolayer Formation and Restores Functional Integrity Following Descemet's Stripping

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Maninder Bhogal; Chan N. Lwin; Xin-Yi Seah; Gary Peh; Jodhbir S. Mehta
TAGS: endothelial dysfunction, endothelial cells, descemet's membrane, endothelium, fluorescent antibody technique, wound healing, wounds and injuries, cornea, transplantation, personal integrity
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4249-4260. doi: 10.1167/iovs.17-22106

Includes: Multimedia, Supplemental Content

Cornea September 2017

Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy

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V. Vinod Mootha; Brock Hansen; Ziye Rong; Pradeep P. Mammen; Zhengyang Zhou; Chao Xing; Xin Gong
TAGS: myotonic dystrophy, endothelial cells, hereditary corneal dystrophy, endothelium, trinucleotide repeats, cornea, rna
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4579-4585. doi: 10.1167/iovs.17-22350

Includes: Supplemental Content

Cornea September 2017

Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6–Dependent Stem Cell Activation and Macrophage Switch

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Guohu Di; Xianli Du; Xia Qi; Xiaowen Zhao; Haoyun Duan; Suxia Li; Lixin Xie; Qingjun Zhou
TAGS: diabetes mellitus, stem cells, epithelium, macrophage, wound healing, cornea, stem cell, mesenchymal
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4344-4354. doi: 10.1167/iovs.17-21506

Includes: Supplemental Content

Physiology and Pharmacology September 2017

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders

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Christian M. Felix; Sujin Lee; Marc H. Levin; Alan S. Verkman
TAGS: cystic fibrosis transmembrane conductance regulator, dry eye syndromes, oryctolagus cuniculus, triazines, pharmacology, transcriptional activation
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4506-4513. doi: 10.1167/iovs.17-22525

Lens September 2017

Performing Reliable Lens Capsulotomy in the Presence of Corneal Edema With a Femtosecond Laser

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Geraint P. Williams; Benjamin L. George; Yoke R. Wong; Gary H. F. Yam; Marcus Ang; Shian C. Tay; Jodhbir S. Mehta
TAGS: corneal edema, in situ nick-end labeling, lens, crystalline, lens (device), cornea, femtosecond pulsed laser device
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4490-4498. doi: 10.1167/iovs.17-22227

Immunology and Microbiology September 2017

Development of a Poly-ε-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis

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Andrew G. Gallagher; Keri McLean; Rosalind M. K. Stewart; Don A. Wellings; Heather E. Allison; Rachel L. Williams
TAGS: antifungal agent, bandage, contact lenses, drug delivery systems, gel, hydrogel, lysine, keratitis, fungal, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4499-4505. doi: 10.1167/iovs.17-22301

Includes: Supplemental Content

Cornea September 2017

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation

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Tarsis F. Gesteira; Mingxia Sun; Yvette M. Coulson-Thomas; Yu Yamaguchi; Lung-Kun Yeh; Vincent Hascall; Vivien J. Coulson-Thomas
TAGS: debridement, stem cells, epithelium, alkalies, burns, wounds and injuries, cornea, mice, epithelial cells, hyaluronan, stem cell niche
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4407-4421. doi: 10.1167/iovs.17-22326

Includes: Supplemental Content

Cornea August 2017

Efficacy of a Fixed Combination of Tetracycline, Chloramphenicol, and Colistimethate Sodium for Treatment of Candida albicans Keratitis

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Anna R. Blanco; Antonia Nostro; Valeria D'Angelo; Manuela D'Arrigo; Maria G. Mazzone; Andreana Marino
TAGS: chloramphenicol, candida albicans, keratitis, tetracycline, antibiotic therapy, keratitis, fungal, colistimethate, free immunoglobulin light chain, killing
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4292-4298. doi: 10.1167/iovs.17-22047

Cornea August 2017

Long-Term Biomechanical and Histologic Results of WST-D/NIR Corneal Stiffening in Rabbits, Up to 8 Months Follow-up

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Jurriaan Brekelmans; Alexandra Goz; Mor M. Dickman; Alexander Brandis; Xiaomeng Sui; H. Daniel Wagner; Rudy M. M. A. Nuijts; Avigdor Scherz; Arie L. Marcovich
TAGS: follow-up, oryctolagus cuniculus, cornea
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4089-4095. doi: 10.1167/iovs.17-22108

Multidisciplinary Ophthalmic Imaging August 2017

Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera

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Mariya Zyablitskaya; Anna Takaoka; Emilia L. Munteanu; Takayuki Nagasaki; Stephen L. Trokel; David C. Paik
TAGS: injection of therapeutic agent, myopia, oryctolagus cuniculus, body tissue, eye, riboflavin, sclera, harmonics, corneal collagen cross-linking
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):21-29. doi: 10.1167/iovs.16-20241

Cornea August 2017

Chondroitin Sulfate–Based Biocompatible Crosslinker Restores Corneal Mechanics and Collagen Alignment

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Xiaokun Wang; Shoumyo Majumdar; Garret Ma; Jeeyeon Sohn; Samuel C. Yiu; Walter Stark; Awad Al-Qarni; Deepak P. Edward; Jennifer H. Elisseeff
TAGS: chondroitin, chondroitin sulfates, collagen, cornea, sulfate, corneal collagen cross-linking, national health service (uk)
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3887-3895. doi: 10.1167/iovs.16-21292

Cornea July 2017

Monocarboxylate Transporters Mediate Fluorescein Uptake in Corneal Epithelial Cells

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Yi-Chen Sun; Hau-Min Liou; Po-Ting Yeh; Wei-Li Chen; Fung-Rong Hu
TAGS: fluorescein, membrane transport proteins, oryctolagus cuniculus, corneal epithelial cell
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3716-3722. doi: 10.1167/iovs.16-20998

Cornea July 2017

Conditionally Immortal Slc4a11 −/− Mouse Corneal Endothelial Cell Line Recapitulates Disrupted Glutaminolysis Seen in Slc4a11 −/− Mouse Model

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Wenlin Zhang; Diego G. Ogando; Edward T. Kim; Moon-Jung Choi; Hongde Li; Jason M. Tenessen; Joseph A. Bonanno
TAGS: endothelial cells, viral tumor antigens, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3723-3731. doi: 10.1167/iovs.17-21781

Cornea July 2017

Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Miu Kitahara; Hirokazu Okuda; Keisuke Hashimoto; Emi Ueda; Makiko Nakahara; Shigeru Kinoshita; Robert D. Young; Andrew J. Quantock; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: apoptosis, polymerase chain reaction, mitochondria, cell death, hereditary corneal dystrophy, endothelium, corneal endothelium, tissue membrane, staurosporine, thapsigargin, cornea, proteins, stress, rna, small interfering, cyclophosphamide, doxorubicin, prednisone, and vincristine, chronic exertional compartment syndrome, unfolded protein response, mitochondrial membranes
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3697-3707. doi: 10.1167/iovs.16-21023

Includes: Supplemental Content

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Astigmatism and Refractive Outcome After Late In-The-Bag Intraocular Lens Dislocation Surgery: A Randomized Clinical Trial

Spatiotemporally Controlled Ablation of Klf5 Results in Dysregulated Epithelial Homeostasis in Adult Mouse Corneas

Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration

Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection

Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways

Allogeneic Descemet's Membrane Transplantation Enhances Corneal Endothelial Monolayer Formation and Restores Functional Integrity Following Descemet's Stripping

Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy

Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6–Dependent Stem Cell Activation and Macrophage Switch

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders

Performing Reliable Lens Capsulotomy in the Presence of Corneal Edema With a Femtosecond Laser

Development of a Poly-ε-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation

Efficacy of a Fixed Combination of Tetracycline, Chloramphenicol, and Colistimethate Sodium for Treatment of Candida albicans Keratitis

Long-Term Biomechanical and Histologic Results of WST-D/NIR Corneal Stiffening in Rabbits, Up to 8 Months Follow-up

Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera

Chondroitin Sulfate–Based Biocompatible Crosslinker Restores Corneal Mechanics and Collagen Alignment

Monocarboxylate Transporters Mediate Fluorescein Uptake in Corneal Epithelial Cells

Conditionally Immortal Slc4a11 −/− Mouse Corneal Endothelial Cell Line Recapitulates Disrupted Glutaminolysis Seen in Slc4a11 −/− Mouse Model

Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy

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