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Special Issue June 2017

Biomarkers and Surrogate Endpoints in Uveitis: The Impact of Quantitative Imaging

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Alastair K. Denniston; Pearse A. Keane; Sunil K. Srivastava
TAGS: inflammation, biological markers, corneal opacity, uveitis, vitreous body, diagnostic imaging, surrogate endpoints
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO131-BIO140. doi: 10.1167/iovs.17-21788

Articles June 2017

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

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Jimmy Chammas; Arnaud Sauer; Joëlle Pizzuto; Fabienne Pouthier; David Gaucher; Jacques Marescaux; Didier Mutter; Tristan Bourcier
TAGS: keratoplasty, penetrating, ophthalmologic surgical procedures, surgical procedures, operative, sutures, cornea, spectral-domain optical coherence tomography
Trans. Vis. Sci. Tech.. 2017; 6(3):21. doi: 10.1167/tvst.6.3.21

Articles June 2017

Association between Corneal Biomechanical Properties with Ocular Response Analyzer and Also CorvisST Tonometry, and Glaucomatous Visual Field Severity

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Kazunori Hirasawa; Masato Matsuura; Hiroshi Murata; Shunsuke Nakakura; Yoshitaka Nakao; Yoshiaki Kiuchi; Ryo Asaoka
TAGS: glaucoma, tonometry, visual fields, cornea, eye
Trans. Vis. Sci. Tech.. 2017; 6(3):18. doi: 10.1167/tvst.6.3.18

Cornea June 2017

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

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Jing Li; Szu-Yu Chen; Xin-Yue Zhao; Ming-Chang Zhang; Hua-Tao Xie
TAGS: signal transduction, western blotting, stem cells, epithelium, ligands, cornea, notch signaling pathway, dual antiplatelet therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2968-2976. doi: 10.1167/iovs.16-20642

Includes: Supplemental Content

Article June 2017

The perception of hazy gloss

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Peter Vangorp; Pascal Barla; Roland W. Fleming
TAGS: corneal opacity, perception
Journal of Vision. 2017; 17(5):19. doi: 10.1167/17.5.19

Includes: Supplemental Content

Cornea June 2017

ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis

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Chen Dong; Nan Gao; Bing X. Ross; Fu-Shin X. Yu
TAGS: candida albicans, flagellin, infection, cornea, mice, host defense, keratitis, fungal, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2948-2958. doi: 10.1167/iovs.17-21476

Cornea June 2017

Visual Performance and Optical Quality of Standardized Asymmetric Soft Contact Lenses in Patients With Keratoconus

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Asaki Suzaki; Naoyuki Maeda; Mutsumi Fuchihata; Shizuka Koh; Kohji Nishida; Takashi Fujikado
TAGS: coma, capillary leak syndrome, contact lenses, contact lenses, hydrophilic, keratoconus, lens, crystalline, lens (device), optics, visual acuity, cornea, quality
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2899-2905. doi: 10.1167/iovs.16-21296

Cornea June 2017

SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal

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Xiling Zheng; Huixia Cui; Yuanyuan Yin; Yajing Zhang; Rongrong Zong; Xiaorui Bao; Jian-xing Ma; Zuguo Liu; Yueping Zhou
TAGS: antioxidants, western blotting, oxidants, wounds and injuries, cornea
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2874-2883. doi: 10.1167/iovs.17-21544

Article June 2017

Variation of axial and oblique astigmatism with accommodation across the visual field

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Tao Liu; Larry N. Thibos
TAGS: visual accommodation, astigmatism, optics, visual fields, cornea, eye
Journal of Vision. 2017; 17(3):24. doi: 10.1167/17.3.24

Visual Neuroscience June 2017

Corneal Potential Maps Measured With Multi-Electrode Electroretinography in Rat Eyes With Experimental Lesions

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Zahra Derafshi; Brian E. Kunzer; Emily M. Mugler; Nataliya Rokhmanova; Dong-Wook Park; Hadi Tajalli; Krithi Shetty; Zhenqiang Ma; Justin C. Williams; John R. Hetling
TAGS: cornea, eye, retina, maps, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2863-2873. doi: 10.1167/iovs.16-20726

Cornea May 2017

KLF4 Plays an Essential Role in Corneal Epithelial Homeostasis by Promoting Epithelial Cell Fate and Suppressing Epithelial–Mesenchymal Transition

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Anil Tiwari; Chelsea L. Loughner; Sudha Swamynathan; Shivalingappa K. Swamynathan
TAGS: epithelium, homeostasis, cyclin d1, antibodies, cornea, survivin, epithelial cells, e-cadherin, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2785-2795. doi: 10.1167/iovs.17-21826

Includes: Supplemental Content

Articles May 2017

Optical Coherence Tomography Reveals Changes to Corneal Reflectivity and Thickness in Individuals with Tear Hyperosmolarity

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Laura Adelaide Deinema; Algis Jonas Vingrys; Holly Rose Chinnery; Laura Elizabeth Downie
TAGS: epithelium, cornea, hyperglycemia hyperosmolar, optical coherence tomography
Trans. Vis. Sci. Tech.. 2017; 6(3):6. doi: 10.1167/tvst.6.3.6

Special Issue May 2017

Decade-Long Profile of Imaging Biomarker Use in Ophthalmic Clinical Trials

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Edoardo Villani; Domenico Massaro; Matteo Scaramuzzi; Pedram Hamrah; Felipe A. Medeiros; Paolo Nucci
TAGS: biological markers, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO76-BIO81. doi: 10.1167/iovs.17-21790

Cornea May 2017

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

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Shizuka Koh; Naoyuki Maeda; Chikako Ikeda; Sanae Asonuma; Mai Ogawa; Takahiro Hiraoka; Tetsuro Oshika; Kohji Nishida
TAGS: contrast sensitivity, dry eye syndromes, vision
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2647-2651. doi: 10.1167/iovs.17-21894

Cornea May 2017

Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma

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Steffi Matthyssen; Sorcha Ní Dhubhghaill; Veerle Van Gerwen; Nadia Zakaria
TAGS: flow cytometry, cell size, corneal stroma, cornea, stem cell, mesenchymal, donors
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2659-2665. doi: 10.1167/iovs.17-21676

Cornea May 2017

Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse

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Lixing W. Reneker; Lanlan Wang; Rebecca T. Irlmeier; Andrew J. W. Huang
TAGS: homeostasis, adult, atrophy, meibomian gland, fibroblast growth factor receptors, mice, fgfr2 gene
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2638-2646. doi: 10.1167/iovs.16-21204

Includes: Supplemental Content

Cornea May 2017

Biomechanical Differences Between Femtosecond Lenticule Extraction (FLEx) and Small Incision Lenticule Extraction (SmILE) Tested by 2D-Extensometry in Ex Vivo Porcine Eyes

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Bogdan Spiru; Sabine Kling; Farhad Hafezi; Walter Sekundo
TAGS: family suidae, cornea, eye, stress
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2591-2595. doi: 10.1167/iovs.16-20211

Special Issue May 2017

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

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Neeta S. Roy; Yi Wei; Eric Kuklinski; Penny A. Asbell
TAGS: biological markers, dry eye syndromes, surrogate endpoints, clinical research
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO1-BIO19. doi: 10.1167/iovs.17-21709

Special Issue May 2017

Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain

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Daniel A. Culver; Albert Dahan; Daiva Bajorunas; Maria Jeziorska; Monique van Velzen; Leon P. H. J. Aarts; Jinny Tavee; Martijn R. Tannemaat; Ann N. Dunne; Rita I. Kirk; Ioannis N. Petropoulos; Anthony Cerami; Rayaz A. Malik; Michael Brines
TAGS: sarcoidosis, growth associated protein 43, nerve fibers, pain, placebos, cornea, neuropathic pain, neuropathy, small-fiber
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO52-BIO60. doi: 10.1167/iovs.16-21291

Includes: Supplemental Content

Immunology and Microbiology May 2017

Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani

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Satya Sree Kolar; Hasna Baidouri; Alison M. McDermott
TAGS: antifungal agent, epithelium, bodily secretions, densitometry, heat (physical force), immunoblotting, peptides, porcine reproductive and respiratory syndrome, rna, messenger, up-regulation (physiology), zymosan, antibodies, cornea, proteins, antimicrobials, rna, small interfering, ll-37 peptide, pattern recognition receptors, clec7a gene, corneal epithelial cell, pathogen-associated molecular pattern molecules, defb4 gene, toll-like receptor 2
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2463-2472. doi: 10.1167/iovs.16-20658

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Biomarkers and Surrogate Endpoints in Uveitis: The Impact of Quantitative Imaging

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

Association between Corneal Biomechanical Properties with Ocular Response Analyzer and Also CorvisST Tonometry, and Glaucomatous Visual Field Severity

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

The perception of hazy gloss

ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis

Visual Performance and Optical Quality of Standardized Asymmetric Soft Contact Lenses in Patients With Keratoconus

SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal

Variation of axial and oblique astigmatism with accommodation across the visual field

Corneal Potential Maps Measured With Multi-Electrode Electroretinography in Rat Eyes With Experimental Lesions

KLF4 Plays an Essential Role in Corneal Epithelial Homeostasis by Promoting Epithelial Cell Fate and Suppressing Epithelial–Mesenchymal Transition

Optical Coherence Tomography Reveals Changes to Corneal Reflectivity and Thickness in Individuals with Tear Hyperosmolarity

Decade-Long Profile of Imaging Biomarker Use in Ophthalmic Clinical Trials

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma

Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse

Biomechanical Differences Between Femtosecond Lenticule Extraction (FLEx) and Small Incision Lenticule Extraction (SmILE) Tested by 2D-Extensometry in Ex Vivo Porcine Eyes

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain

Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani

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