Cornea

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Biochemistry and Molecular Biology January 2023

Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation

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Emma N. Finburgh; Olivier Mauduit; Takako Noguchi; Jennifer J. Bu; Anser A. Abbas; Dominic F. Hakim; Saverio Bellusci; Robyn Meech; Helen P. Makarenkova; Natalie A. Afshari
TAGS: fgf10 protein, human, cornea, mice, adult, langer-giedion syndrome, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):21. doi: https://doi.org/10.1167/iovs.64.1.21

Cornea January 2023

Effect of TRPM8 Functional Loss on Corneal Epithelial Wound Healing in Mice

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Lili Ran; Jing Feng; Xia Qi; Ting Liu; Benxiang Qi; Kai Jiang; Zhenzhen Zhang; Yang Yu; Qingjun Zhou; Lixin Xie
TAGS: cornea, epithelium, mice, wound healing
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):19. doi: https://doi.org/10.1167/iovs.64.1.19

Includes: Supplemental Content

Cornea January 2023

Effect of Model Tear Film Lipid Layer on Water Evaporation

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Xiaojie Xu; Guangle Li; Yi Y. Zuo
TAGS: evaporation, lipids, tear film finding, water, manganese
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):13. doi: https://doi.org/10.1167/iovs.64.1.13

Includes: Multimedia, Supplemental Content

Cornea January 2023

ETS1–HMGA2 Axis Promotes Human Limbal Epithelial Stem Cell Proliferation

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Bofeng Wang; Huizhen Guo; Dongmei Liu; Siqi Wu; Jiafeng Liu; Xihong Lan; Huaxing Huang; Fengjiao An; Jin Zhu; Jianping Ji; Li Wang; Hong Ouyang; Mingsen Li
TAGS: epithelial stem cells, genes, hmga2 protein, chromatin immunoprecipitation sequencing, epithelium, protein overexpression, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):12. doi: https://doi.org/10.1167/iovs.64.1.12

Includes: Supplemental Content

Physiology and Pharmacology January 2023

Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model

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Yun Zhang; Nenghua Zhou; Yan Jiao; Guifeng Lin; Xun Li; Sheng Gao; Pei Zhou; Jingming Liu; Jinshan Nan; Meixia Zhang; Shengyong Yang
TAGS: ambulatory surgery center, inflammasomes, inflammation, keratitis, mice, nlr family, pyrin domain-containing 3 protein, pyroptosis, caspases
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):1. doi: https://doi.org/10.1167/iovs.64.1.1

Includes: Supplemental Content

Cornea January 2023

Association of Tear Osmolarity With Signs and Symptoms of Dry Eye Disease in the Dry Eye Assessment and Management (DREAM) Study

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Jack V. Greiner; Gui-shuang Ying; Maxwell Pistilli; Maureen G. Maguire; Penny A. Asbell; for the Dry Eye Assessment and Management (DREAM) Study Research Group
TAGS: dreams, dry eye syndromes, osmolar concentration, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):5. doi: https://doi.org/10.1167/iovs.64.1.5

Includes: Supplemental Content

Cornea & External Disease January 2023

Corneal Biomechanical Characteristics in Osteogenesis Imperfecta With Collagen Defect

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Chien-Chih Chou; Po-Jen Shih; Tzuu-Shuh Jou; Min-Yen Hsu; Jun-Peng Chen; Rai-Hseng Hsu; Ni-Chung Lee; Yin-Hsiu Chien; Wuh-Liang Hwu; I-Jong Wang
TAGS: collagen, cornea, osteogenesis imperfecta, biomechanics, keratoconus
Trans. Vis. Sci. Tech.. 2023; 12(1):14. doi: https://doi.org/10.1167/tvst.12.1.14

Includes: Supplemental Content

Cornea & External Disease January 2023

Deep Convolutional Neural Networks Detect no Morphological Differences Between Culture-Positive and Culture-Negative Infectious Keratitis Images

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Kaitlin Kogachi; Prajna Lalitha; N. Venkatesh Prajna; Rameshkumar Gunasekaran; Jeremy D. Keenan; J. Peter Campbell; Xubo Song; Travis K. Redd
TAGS: convolutional neural networks, keratitis, corneal ulcer
Trans. Vis. Sci. Tech.. 2023; 12(1):12. doi: https://doi.org/10.1167/tvst.12.1.12

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit January 2023

Establishment of a Beagle Dog Model of Dry Eye Disease

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Zhi-zheng Li; Yan-ping Zou; Hui Zhu; Wei-zhen Zeng; Yi Ding; Jia-zeng Su; Guang-yan Yu
TAGS: cornea, dog, domestic, dry eye syndromes, eye, molecule, surgical procedures, operative, fluorescein stain method, conjunctiva, ocular surfaces, bodily secretions
Trans. Vis. Sci. Tech.. 2023; 12(1):2. doi: https://doi.org/10.1167/tvst.12.1.2

Artificial Intelligence December 2022

Deep Learning Model for the Detection of Corneal Edema Before Descemet Membrane Endothelial Keratoplasty on Optical Coherence Tomography Images

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Karen Bitton; Pierre Zéboulon; Wassim Ghazal; Maria Rizk; Sina Elahi; Damien Gatinel
TAGS: cornea, corneal edema, deep learning, descemet membrane endothelial keratoplasty, edema, optical coherence tomography, dcct trial, surgical procedures, operative, preoperative care
Trans. Vis. Sci. Tech.. 2022; 11(12):19. doi: https://doi.org/10.1167/tvst.11.12.19

Cornea & External Disease December 2022

Ex Vivo Evaluation of a Pressure-Sensitive Device to Aid Big Bubble Intrastromal Dissection in Deep Anterior Lamellar Keratoplasty

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Alfonso Iovieno; Luigi Fontana; Marco Coassin; Dario Bovio; Caterina Salito
TAGS: keratoplasty, tissue dissection
Trans. Vis. Sci. Tech.. 2022; 11(12):17. doi: https://doi.org/10.1167/tvst.11.12.17

Includes: Multimedia, Supplemental Content

Cornea & External Disease December 2022

Vitamin D Supplementation Impacts Systemic Biomarkers of Collagen Degradation and Copper Metabolism in Patients With Keratoconus

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Romina Mayra Lasagni Vitar; Philippe Fonteyne; Karl Anders Knutsson; Federico Bertuzzi; Laura Galli; Paolo Rama; Giulio Ferrari
TAGS: biological markers, catabolism, collagen, copper, keratoconus, metabolism, vitamin d
Trans. Vis. Sci. Tech.. 2022; 11(12):16. doi: https://doi.org/10.1167/tvst.11.12.16

Includes: Supplemental Content

Cornea & External Disease December 2022

Relative Stability of Regional Facial and Ocular Temperature Measurements in Healthy Individuals

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Eleonora Micheletti; Nevin W. El-Nimri; Robert N. Weinreb; John H. K. Liu
TAGS: body temperature, face, temperature, cornea, forehead
Trans. Vis. Sci. Tech.. 2022; 11(12):15. doi: https://doi.org/10.1167/tvst.11.12.15

Includes: Supplemental Content

Cornea December 2022

Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures

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Wei Zhang; Alfrun Schönberg; Fiona Bassett; Karina Hadrian; Deniz Hos; Martina Becker; Felix Bock; Claus Cursiefen
TAGS: cornea, keratoplasty, wounds and injuries, mice, angiogenesis, lymph, alkalies, burns, sutures, inflammatory cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):18. doi: https://doi.org/10.1167/iovs.63.13.18

Includes: Supplemental Content

Cornea December 2022

The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation

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Jessica Feldt; Angela Garriz; Maria C. Rodriguez Benavente; Ashley M. Woodward; Driss Zoukhri; Pablo Argüeso
TAGS: adult, inflammation, lacrimal gland, proteins, sparc study
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):8. doi: https://doi.org/10.1167/iovs.63.13.8

Cornea December 2022

Hyaluronan Modulates the Biomechanical Properties of the Cornea

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Xiao Lin; Taye Mekonnen; Sudhir Verma; Christian Zevallos-Delgado; Manmohan Singh; Salavat R. Aglyamov; Tarsis F. Gesteira; Kirill V. Larin; Vivien J. Coulson-Thomas
TAGS: cornea, hyaluronan, mice
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):6. doi: https://doi.org/10.1167/iovs.63.13.6

Includes: Supplemental Content

Cornea & External Disease December 2022

MicroRNA Profiling in the Aqueous Humor of Keratoconus Eyes

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Yingjie Zhang; Danyang Che; Yiting Cao; Yu Yue; Tianrui He; Yi Zhu; Jibo Zhou
TAGS: hypertension, micrornas, eye
Trans. Vis. Sci. Tech.. 2022; 11(12):5. doi: https://doi.org/10.1167/tvst.11.12.5

Cornea & External Disease December 2022

Proteomic Analysis of Meibomian Gland Secretions in Patients With Blepharokeratoconjunctivitis

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Jingjing Su; Hongwei Li; Baotao Lin; Shuiming Li; Xiaoping Zhou; Wei Li; Ping Guo
TAGS: bodily secretions, meibomian gland, proteins, proteomics, signs and symptoms
Trans. Vis. Sci. Tech.. 2022; 11(12):4. doi: https://doi.org/10.1167/tvst.11.12.4

Includes: Supplemental Content

Cornea December 2022

Insufficient Dose of ERCC8 Protein Caused by a Frameshift Mutation Is Associated With Keratoconus With Congenital Cataracts

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Xiao-Dan Hao; Yi-Zhi Yao; Kai-Ge Xu; Bin Dong; Wen-Hua Xu; Jing-Jing Zhang
TAGS: congenital cataract, proteins, keratoconus, frameshift mutation function
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):1. doi: https://doi.org/10.1167/iovs.63.13.1

Includes: Supplemental Content

Cornea & External Disease November 2022

Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) Demonstrates Safety, Low Systemic Exposure, and No Anesthetic Effect in Healthy Participants

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Kalliopi Stasi; Qusai Alshare; Monish Jain; Michael Wald; Yifang Li
TAGS: anesthetics, cornea, safety, transient receptor potential v1 antagonists
Trans. Vis. Sci. Tech.. 2022; 11(11):15. doi: https://doi.org/10.1167/tvst.11.11.15

Includes: Supplemental Content

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Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation

Effect of TRPM8 Functional Loss on Corneal Epithelial Wound Healing in Mice

Effect of Model Tear Film Lipid Layer on Water Evaporation

ETS1–HMGA2 Axis Promotes Human Limbal Epithelial Stem Cell Proliferation

Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model

Association of Tear Osmolarity With Signs and Symptoms of Dry Eye Disease in the Dry Eye Assessment and Management (DREAM) Study

Corneal Biomechanical Characteristics in Osteogenesis Imperfecta With Collagen Defect

Deep Convolutional Neural Networks Detect no Morphological Differences Between Culture-Positive and Culture-Negative Infectious Keratitis Images

Establishment of a Beagle Dog Model of Dry Eye Disease

Deep Learning Model for the Detection of Corneal Edema Before Descemet Membrane Endothelial Keratoplasty on Optical Coherence Tomography Images

Ex Vivo Evaluation of a Pressure-Sensitive Device to Aid Big Bubble Intrastromal Dissection in Deep Anterior Lamellar Keratoplasty

Vitamin D Supplementation Impacts Systemic Biomarkers of Collagen Degradation and Copper Metabolism in Patients With Keratoconus

Relative Stability of Regional Facial and Ocular Temperature Measurements in Healthy Individuals

Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures

The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation

Hyaluronan Modulates the Biomechanical Properties of the Cornea

MicroRNA Profiling in the Aqueous Humor of Keratoconus Eyes

Proteomic Analysis of Meibomian Gland Secretions in Patients With Blepharokeratoconjunctivitis

Insufficient Dose of ERCC8 Protein Caused by a Frameshift Mutation Is Associated With Keratoconus With Congenital Cataracts

Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) Demonstrates Safety, Low Systemic Exposure, and No Anesthetic Effect in Healthy Participants

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