External Eye Disease

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Cornea May 2017

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

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Shizuka Koh; Naoyuki Maeda; Chikako Ikeda; Sanae Asonuma; Mai Ogawa; Takahiro Hiraoka; Tetsuro Oshika; Kohji Nishida
TAGS: contrast sensitivity, dry eye syndromes, vision
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2647-2651. doi: 10.1167/iovs.17-21894

Special Issue May 2017

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

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Neeta S. Roy; Yi Wei; Eric Kuklinski; Penny A. Asbell
TAGS: biological markers, dry eye syndromes, surrogate endpoints, clinical research
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO1-BIO19. doi: 10.1167/iovs.17-21709

Cornea April 2017

Correlation Between the Inflammatory Marker HLA-DR and Signs and Symptoms in Moderate to Severe Dry Eye Disease

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Françoise Brignole-Baudouin; Luisa Riancho; Dahlia Ismail; Maëva Deniaud; Mourad Amrane; Christophe Baudouin
TAGS: inflammatory markers, dry eye syndromes, signs and symptoms, hla-dr antigens
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2438-2448. doi: 10.1167/iovs.15-16555

Includes: Supplemental Content

Cornea April 2017

Enhanced Tearing by Electrical Stimulation of the Anterior Ethmoid Nerve

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Mark Brinton; Andrea L. Kossler; Zara M. Patel; James Loudin; Manfred Franke; Christopher N. Ta; Daniel Palanker
TAGS: bodily secretions, dry eye syndromes, electric stimulation, ethmoid bone, neurons, oryctolagus cuniculus, lipids, proteins, volume, tear film finding, osmolar concentration
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2341-2348. doi: 10.1167/iovs.16-21362

Cornea April 2017

Expression Profiling of Nonpolar Lipids in Meibum From Patients With Dry Eye: A Pilot Study

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Jianzhong Chen; Jeremy K. Keirsey; Kari B. Green; Kelly K. Nichols
TAGS: dry eye syndromes, gene expression profiling, lipids, fasting lipid profile, molecular profiling, pilot projects
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2266-2274. doi: 10.1167/iovs.16-20902

Includes: Supplemental Content

Cornea March 2017

Therapeutic Efficacy of Nanocomplex of Poly(Ethylene Glycol) and Catechin for Dry Eye Disease in a Mouse Model

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Hyesook Lee; Whuisu Shim; Chae Eun Kim; So Yeon Choi; Haeshin Lee; Jaewook Yang
TAGS: catechin, dry eye syndromes, cornea, ethylene glycol, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1682-1691. doi: 10.1167/iovs.16-20843

Letters to the Editor March 2017

Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis: Some Discussions

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Ying Liu
TAGS: oryctolagus cuniculus, stem cell, mesenchymal, dacryoadenitis, lymphocyte, autoimmunity
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1585-1585. doi: 10.1167/iovs.17-21694

Cornea February 2017

Anti-Inflammatory and Antioxidative Effects of Camellia japonica on Human Corneal Epithelial Cells and Experimental Dry Eye: In Vivo and In Vitro Study

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Hyo Seok Lee; Joo-Hee Choi; Lian Cui; Ying Li; Jee Myung Yang; Je-Jung Yun; Ji Eun Jung; Won Choi; Kyung Chul Yoon
TAGS: anti-inflammatory agents, cytokine, chemokine, camellia, dry eye syndromes, hydrogen peroxide, conjunctiva, cornea, mice, proteins, fluorescein stain method, volume, corneal epithelial cell
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1196-1207. doi: 10.1167/iovs.16-20634

Cornea February 2017

T Cell–Derived Granulocyte-Macrophage Colony-Stimulating Factor Contributes to Dry Eye Disease Pathogenesis by Promoting CD11b+ Myeloid Cell Maturation and Migration

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Thomas H. Dohlman; Julia Ding; Reza Dana; Sunil K. Chauhan
TAGS: granulocyte-macrophage colony-stimulating factor, dry eye syndromes, recombinant granulocyte-macrophage colony-stimulating factors, myeloid cells, t-lymphocyte, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1330-1336. doi: 10.1167/iovs.16-20789

Cornea February 2017

Clinic-Based Study on Meibomian Gland Dysfunction in Japan

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Shiro Amano; Kenji Inoue
TAGS: dry eye syndromes, meibomian gland, questionnaires, signs and symptoms, prevalence, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1283-1287. doi: 10.1167/iovs.16-21374

Clinical and Epidemiologic Research February 2017

Measuring Trachomatous Inflammation-Intense (TI) When Prevalence Is Low Provides Data on Infection With Chlamydia trachomatis

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Andrea I. Zambrano; Beatriz E. Muñoz; Harran Mkocha; Laura Dize; Charlotte A. Gaydos; Thomas Quinn; Sheila K. West
TAGS: inflammation, chlamydia trachomatis, trachoma, infection, prevalence, surveys
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):997-1000. doi: 10.1167/iovs.16-20421

Immunology and Microbiology January 2017

Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction

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Nozomi Matsumura; Satoshi Goto; Eiichi Uchio; Kyoko Nakajima; Takeshi Fujita; Kazuaki Kadonosono
TAGS: cytokine, lacrimal duct obstruction, pediatrics, interleukin-6
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):252-256. doi: 10.1167/iovs.16-20717

Articles December 2016

Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms

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Rohit Shetty; Swaminathan Sethu; Priyanka Chevour; Kalyani Deshpande; Natasha Pahuja; Harsha Nagaraja; Narendra Pindipapanahalli; Arkasubhra Ghosh
TAGS: cytokine, dry eye syndromes, signs and symptoms, vitamin d
Trans. Vis. Sci. Tech.. 2016; 5(6):16. doi: 10.1167/tvst.5.6.16

Cornea November 2016

Safety and Efficacy Clinical Trials for SYL1001, a Novel Short Interfering RNA for the Treatment of Dry Eye Disease

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José Manuel Benitez-Del-Castillo; Javier Moreno-Montañés; Ignacio Jiménez-Alfaro; Francisco José Muñoz-Negrete; Krista Turman; Kadi Palumaa; Belén Sádaba; María Victoria González; Verónica Ruz; Beatriz Vargas; Covadonga Pañeda; Tamara Martínez; Anne-Marie Bleau; Ana Isabel Jimenez
TAGS: phase 2 clinical trials, dry eye syndromes, placebos, safety, eye, rna, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2016; 57(14):6447-6454. doi: 10.1167/iovs.16-20303

Includes: Supplemental Content

Glaucoma November 2016

In Vivo Distribution of Corneal Epithelial Dendritic Cells in Patients With Glaucoma

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Rodolfo Mastropasqua; Luca Agnifili; Vincenzo Fasanella; Andrea Lappa; Lorenza Brescia; Manuela Lanzini; Francesco Oddone; Paolo Perri; Leonardo Mastropasqua
TAGS: epithelium, glaucoma, dendritic cells, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2016; 57(14):5996-6002. doi: 10.1167/iovs.16-20333

Cornea October 2016

Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease

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David Charles Jackson; Weiguang Zeng; Chinn Yi Wong; Edin Jessica Mifsud; Nicholas Andrew Williamson; Ching-Seng Ang; Algis Jonas Vingrys; Laura Elizabeth Downie
TAGS: cytokine, biological markers, dry eye syndromes, interferon type ii, osmolar concentration, hyperosmolality, mass or substance concentration per volume, schirmer tear test procedure, hyperglycemia hyperosmolar
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4824-4830. doi: 10.1167/iovs.16-19757

Cornea October 2016

Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome

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Nancy A. McNamara; Shaokui Ge; Salena M. Lee; Alison M. Enghauser; Lindsey Kuehl; Feeling Y.-T. Chen; Marianne Gallup; Robert L. McKown
TAGS: enzyme-linked immunosorbent assay, dry eye syndromes, neurons, sjogren's syndrome, cornea, neuropathy
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5237-5243. doi: 10.1167/iovs.16-19309

Immunology and Microbiology October 2016

Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis

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Xue Li; Xiaoxiao Lu; Deming Sun; Xilian Wang; Liyuan Yang; Shaozhen Zhao; Hong Nian; Ruihua Wei
TAGS: autoimmunity, langer-giedion syndrome, lymphocyte, oryctolagus cuniculus, stem cell, mesenchymal, dacryoadenitis
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5161-5170. doi: 10.1167/iovs.15-17824

Cornea September 2016

Assessment of Transepidermal Water Loss From the Ocular Area in Dry Eye Disease

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Hyun Sun Jeon; Sang Woong Youn; Hee Eun Jeon; Joo Hyun Kim; Joon Young Hyon
TAGS: dry eye syndromes, evaporation, transepidermal water loss rate
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4831-4836. doi: 10.1167/iovs.16-20109

Cornea September 2016

In Vivo Confocal Microscopy in Dry Eye Disease Associated With Chronic Graft-Versus-Host Disease

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Ahmad Kheirkhah; Yureeda Qazi; Michael A. Arnoldner; Kunal Suri; Reza Dana
TAGS: graft-versus-host disease, dry eye syndromes, microscopy, confocal, conjunctiva, cornea, graft-versus-host disease, chronic
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4686-4691. doi: 10.1167/iovs.16-20013

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The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

Correlation Between the Inflammatory Marker HLA-DR and Signs and Symptoms in Moderate to Severe Dry Eye Disease

Enhanced Tearing by Electrical Stimulation of the Anterior Ethmoid Nerve

Expression Profiling of Nonpolar Lipids in Meibum From Patients With Dry Eye: A Pilot Study

Therapeutic Efficacy of Nanocomplex of Poly(Ethylene Glycol) and Catechin for Dry Eye Disease in a Mouse Model

Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis: Some Discussions

Anti-Inflammatory and Antioxidative Effects of Camellia japonica on Human Corneal Epithelial Cells and Experimental Dry Eye: In Vivo and In Vitro Study

T Cell–Derived Granulocyte-Macrophage Colony-Stimulating Factor Contributes to Dry Eye Disease Pathogenesis by Promoting CD11b+ Myeloid Cell Maturation and Migration

Clinic-Based Study on Meibomian Gland Dysfunction in Japan

Measuring Trachomatous Inflammation-Intense (TI) When Prevalence Is Low Provides Data on Infection With Chlamydia trachomatis

Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction

Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms

Safety and Efficacy Clinical Trials for SYL1001, a Novel Short Interfering RNA for the Treatment of Dry Eye Disease

In Vivo Distribution of Corneal Epithelial Dendritic Cells in Patients With Glaucoma

Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease

Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome

Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis

Assessment of Transepidermal Water Loss From the Ocular Area in Dry Eye Disease

In Vivo Confocal Microscopy in Dry Eye Disease Associated With Chronic Graft-Versus-Host Disease

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