External Eye Disease

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Cornea September 2023

Bacillus-Derived Manganese Superoxide Dismutase Relieves Ocular-Surface Inflammation and Damage by Reducing Oxidative Stress and Apoptosis in Dry Eye

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Hyeon-Jeong Yoon; Rujun Jin; Hee Su Yoon; Ji Suk Choi; Yenny Kim; Seung Hyun Pan; Inik Chang; Lan Li; Ying Li; Jonghwa Kim; Kyung Chul Yoon
TAGS: apoptosis, bacillus, conjunctiva, cornea, cyclosporine, dry eye syndromes, inflammation, manganese, mice, ocular surfaces
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):30. https://doi.org/10.1167/iovs.64.12.30

Cornea September 2023

Association of Ocular Surface Immune Cells With Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study

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Eric J. Kuklinski; Yinxi Yu; Gui-Shuang Ying; Penny A. Asbell; for the DREAM Study Research Group
TAGS: dreams, dry eye syndromes, ocular surfaces, signs and symptoms, eye
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):7. https://doi.org/10.1167/iovs.64.12.7

Clinical Trials August 2023

Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm – A Randomized Pilot Study

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Rona Z. Silkiss; Jayson Koppinger; Timothy Truong; David Gibson; Christopher Tyler
TAGS: blepharospasm, botulinum toxins, cannabidiol, eyelid, pilot projects, placebos, signs and symptoms, velocity
Trans. Vis. Sci. Tech.. 2023; 12(8):17. https://doi.org/10.1167/tvst.12.8.17

Includes: Supplemental Content

Cornea August 2023

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1 -Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease

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Xiaojie Xu; Amber Wilkerson; Guangle Li; Igor A. Butovich; Yi Y. Zuo
TAGS: dry eye syndromes, lipids, meibomian gland dysfunction, mice, biophysics
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):20. https://doi.org/10.1167/iovs.64.11.20

Includes: Supplemental Content

Anatomy and Pathology/Oncology August 2023

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype

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Jeremias G. Galletti; Kaitlin K. Scholand; Claudia M. Trujillo-Vargas; Wolfgang Haap; Tiago Santos-Ferreira; Christoph Ullmer; Zhiyuan Yu; Cintia S. de Paiva
TAGS: aging, cathepsins, dry eye syndromes, mice, phenotype, diet
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):7. https://doi.org/10.1167/iovs.64.11.7

Includes: Supplemental Content

Low Vision Rehabilitation August 2023

An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept

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Nish Mohith Kurukuti; Melanie Nadeau; Eleftherios I. Paschalis; Kevin E. Houston
TAGS: eye, eyelid, eyelid ptosis, magnets, proof of concept studies, prostheses, french guiana
Trans. Vis. Sci. Tech.. 2023; 12(8):11. https://doi.org/10.1167/tvst.12.8.11

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2023

Intrinsic Disorder in the Human Tear Proteome

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David J. Taylor Gonzalez; Mak Djulbegovic; Michael Antonietti; Matthew Cordova; Guy W. Dayhoff, II; Robby Mattes; Anat Galor; Vladimir N. Uversky; Carol L. Karp
TAGS: proteins, proteome
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):14. https://doi.org/10.1167/iovs.64.11.14

Includes: Supplemental Content

Clinical Trials August 2023

Effects of Carboxymethylcellulose Artificial Tears on Ocular Surface Microbiome Diversity and Composition, A Randomized Controlled Trial

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Yujia Zhou; Gurjit S. Sidhu; Joan A. Whitlock; Bishoy Abdelmalik; Zachary Mayer; Youlei Li; Gary P. Wang; Walter A. Steigleman
TAGS: antithymoglobulin, arterial tortuosity syndrome, carboxymethylcellulose, eye, microbiome, ocular lubricants, ocular surfaces, periodic paralysis, potassium-sensitive cardiodysrhythmic type, randomized controlled trial, signs and symptoms
Trans. Vis. Sci. Tech.. 2023; 12(8):5. https://doi.org/10.1167/tvst.12.8.5

Immunology and Microbiology August 2023

Thymosin β4 Alleviates Autoimmune Dacryoadenitis via Suppressing Th17 Cell Response

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Xiaoyu Zhao; Na Li; Ning Yang; Baoyue Mi; Weiyu Dang; Deming Sun; Shanshan Ma; Hong Nian; Ruihua Wei
TAGS: autoimmunity, dacryoadenitis, dry eye syndromes, langer-giedion syndrome, th17 cells, thymosin, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):3. https://doi.org/10.1167/iovs.64.11.3

Includes: Supplemental Content

Clinical and Epidemiologic Research July 2023

Air Pollution and Meteorological Conditions Significantly Associated With Vernal Keratoconjunctivitis Exacerbations

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Eran Levanon; Ido Peles; Michal Gordon; Lena Novack; Erez Tsumi
TAGS: air pollution, keratoconjunctivitis, vernal, environmental factors
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):37. https://doi.org/10.1167/iovs.64.10.37

Includes: Supplemental Content

Immunology and Microbiology July 2023

Blocking Th2 Signaling Pathway Alleviates the Clinical Symptoms and Inflammation in Allergic Conjunctivitis

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Zhiyan Tao; Wei Liu; Qin Chen; Libo Zhang; Kaiqin She; Guoqing Zhao; Licong Liang; Xuhong Chen; Yiliu Yang; Qin Song; Fang Lu
TAGS: allergic conjunctivitis, inflammation, interleukin-13, interleukin-4, signal pathway, signal transduction, signal transduction pathways, signs and symptoms, conjunctival epithelial cells, cytokine
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):30. https://doi.org/10.1167/iovs.64.10.30

Cornea July 2023

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis

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Saumya Nagar; Layla Ajouz; Kelly K. Nichols; Sandeep Kumar; Cathy Zhao; Kugen K. Naidoo; Michael R. Robinson; Douglas Borchman
TAGS: lipids, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):22. https://doi.org/10.1167/iovs.64.10.22

Includes: Supplemental Content

Cornea June 2023

Ferroptosis in the Lacrimal Gland Is Involved in Dry Eye Syndrome Induced by Corneal Nerve Severing

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Xuan Liu; Zedu Cui; Xi Chen; Yan Li; Jin Qiu; Yuke Huang; Xiao Wang; Shuilian Chen; Qian Luo; Pei Chen; Jing Zhuang; Keming Yu
TAGS: cornea, dry eye syndromes, ferroptosis, lacrimal gland, neurons
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):27. https://doi.org/10.1167/iovs.64.7.27

Includes: Supplemental Content

Cornea & External Disease June 2023

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca

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Stephen P. Yoon; Zhiyuan Yu; Stephen C. Pflugfelder; Cintia S. de Paiva
TAGS: proteins, sjogren's syndrome, keratoconjunctivitis sicca
Trans. Vis. Sci. Tech.. 2023; 12(6):8. https://doi.org/10.1167/tvst.12.6.8

Includes: Supplemental Content

Clinical and Epidemiologic Research June 2023

Autonomic Nerve Activity Features According to Dry Eye Type

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Minako Kaido; Reiko Arita; Yasue Mitsukura; Kazuo Tsubota
TAGS: autonomic nervous system, dry eye syndromes, neurons, signs and symptoms, stress, questionnaires
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):19. https://doi.org/10.1167/iovs.64.7.19

Includes: Supplemental Content

Cornea May 2023

Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats

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Kasumi Kikuchi; Yoshiaki Tagawa; Miyuki Murata; Susumu Ishida
TAGS: cornea, dry eye syndromes, hyperalgesia, ocular pain, rats, eye, excision
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):27. https://doi.org/10.1167/iovs.64.5.27

Immunology and Microbiology April 2023

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model

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Zhiyuan Yu; Ghasem Yazdanpanah; Jehan Alam; Cintia S. de Paiva; Stephen Pflugfelder
TAGS: corneal epithelium, dry eye syndromes, nf-kappa b, stress, nlr family, pyrin domain-containing 3 protein, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):8. https://doi.org/10.1167/iovs.64.4.8

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2023

Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis

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Jiayu Bao; Peng Zhang; Binge Wu; Jingyi Wang; Siyuan Li; Ao Li; Ying Jie
TAGS: allergic conjunctivitis, immunoglobulin e, inflammation, mice, proteins, stat3 protein, histamine, ovum, interleukin-4, conjunctiva
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):5. https://doi.org/10.1167/iovs.64.4.5

Includes: Supplemental Content

Immunology and Microbiology April 2023

The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis

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Shruti Singh Kakan; Xiaoyang Li; Maria C. Edman; Curtis T. Okamoto; Brooke E. Hjelm; Sarah F. Hamm-Alvarez
TAGS: dacryoadenitis, mice, micrornas, autoimmunity, sjogren's syndrome, mice, inbred nod, lacrimal gland
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):1. https://doi.org/10.1167/iovs.64.4.1

Includes: Supplemental Content

Cornea March 2023

IFN-γ Facilitates Corneal Epithelial Cell Pyroptosis Through the JAK2/STAT1 Pathway in Dry Eye

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Xue Yang; Xin Zuo; Hao Zeng; Kai Liao; Dalian He; Bowen Wang; Jin Yuan
TAGS: cornea, corneal epithelial cells, dry eye syndromes, pyroptosis, stat1 gene, stress, mice, fluorescent antibody technique, interferon type ii
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):34. https://doi.org/10.1167/iovs.64.3.34

Includes: Supplemental Content

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Bacillus-Derived Manganese Superoxide Dismutase Relieves Ocular-Surface Inflammation and Damage by Reducing Oxidative Stress and Apoptosis in Dry Eye

Association of Ocular Surface Immune Cells With Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study

Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm – A Randomized Pilot Study

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1 -Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype

An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept

Intrinsic Disorder in the Human Tear Proteome

Effects of Carboxymethylcellulose Artificial Tears on Ocular Surface Microbiome Diversity and Composition, A Randomized Controlled Trial

Thymosin β4 Alleviates Autoimmune Dacryoadenitis via Suppressing Th17 Cell Response

Air Pollution and Meteorological Conditions Significantly Associated With Vernal Keratoconjunctivitis Exacerbations

Blocking Th2 Signaling Pathway Alleviates the Clinical Symptoms and Inflammation in Allergic Conjunctivitis

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis

Ferroptosis in the Lacrimal Gland Is Involved in Dry Eye Syndrome Induced by Corneal Nerve Severing

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca

Autonomic Nerve Activity Features According to Dry Eye Type

Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model

Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis

The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis

IFN-γ Facilitates Corneal Epithelial Cell Pyroptosis Through the JAK2/STAT1 Pathway in Dry Eye

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