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New Developments in Vision Research August 2017

Peptide Nucleic Acid–Fluorescence In Situ Hybridization for Detection of Staphylococci From Endophthalmitis Isolates: A Proof-of-Concept Study

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Nimesh Patel; Darlene Miller; Nidhi Relhan; Harry W. Flynn, Jr
TAGS: fluorescent in situ hybridization, endophthalmitis, peptide nucleic acids, staphylococcus
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4027-4029. doi: 10.1167/iovs.17-21535

Retina August 2017

Novel Insights Into the Phenotypical Spectrum of KIF11 -Associated Retinopathy, Including a New Form of Retinal Ciliopathy

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Johannes Birtel; Martin Gliem; Elisabeth Mangold; Lars Tebbe; Isabel Spier; Philipp L. Müller; Frank G. Holz; Christine Neuhaus; Uwe Wolfrum; Hanno J. Bolz; Peter Charbel Issa
TAGS: phenotype, retinal diseases, ciliopathies
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3950-3959. doi: 10.1167/iovs.17-21679

Includes: Supplemental Content

Special Issue August 2017

Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration

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José Cunha-Vaz; Luísa Ribeiro; Miguel Costa; Rafael Simó
TAGS: phenotype, diabetic retinopathy, longitudinal studies, nonproliferative diabetic retinopathy, macular edema
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO206-BIO210. doi: 10.1167/iovs.17-21780

Genetics August 2017

Leber's Hereditary Optic Neuropathy–Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India

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Nahid Akhtar Khan; Periyasamy Govindaraj; Nagasamy Soumittra; Sonika Sharma; Sundaramoorthy Srilekha; Selvakumar Ambika; Ayyasamy Vanniarajan; Angamuthu Kanikannan Meena; Megha S. Uppin; Challa Sundaram; Parayil Sankaran Bindu; Narayanappa Gayathri; Arun B. Taly; Kumarasamy Thangaraj
TAGS: mutation, mitochondria, dna, mitochondrial, india, optic atrophy, hereditary, leber
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3923-3930. doi: 10.1167/iovs.16-20695

Includes: Supplemental Content

Lens August 2017

β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

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Yichen Wang; Anne M. Terrell; Brittany A. Riggio; Deepti Anand; Salil A. Lachke; Melinda K. Duncan
TAGS: integrins, stress response, fibrosis, lens, crystalline, lens (device), egr1 gene
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3896-3922. doi: 10.1167/iovs.17-21721

Includes: Supplemental Content

Genetics August 2017

Choroidal Vasculature in Bietti Crystalline Dystrophy With CYP4V2 Mutations and in Retinitis Pigmentosa With EYS Mutations

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Takako Hirashima; Manabu Miyata; Kenji Ishihara; Tomoko Hasegawa; Masako Sugahara; Ken Ogino; Munemitsu Yoshikawa; Masayuki Hata; Yoshimasa Kuroda; Yuki Muraoka; Sotaro Ooto; Nagahisa Yoshimura
TAGS: mutation, retinitis pigmentosa, vascular network, crystal structure
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3871-3878. doi: 10.1167/iovs.17-21515

Includes: Supplemental Content

Genetics August 2017

C2orf71 Mutations as a Frequent Cause of Autosomal-Recessive Retinitis Pigmentosa: Clinical Analysis and Presentation of 8 Novel Mutations

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Christina Gerth-Kahlert; Amit Tiwari; James V. M. Hanson; Vaishnavi Batmanabane; Elias Traboulsi; Mark E. Pennesi; Abdullah A. Al-Qahtani; Byron L. Lam; John Heckenlively; Sandrine A. Zweifel; Ajoy Vincent; Fabienne Fierz; Daniel Barthelmes; Kari Branham; Naheed Khan; Angela Bahr; Luzy Baehr; István Magyar; Samuel Koller; Silvia Azzarello-Burri; Dunja Niedrist; Elise Heon; Wolfgang Berger
TAGS: phenotype, mutation, genes, retinitis pigmentosa, autosomal recessive inheritance, disorder of macula of retina, morphology, de novo mutation, language morphology
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3840-3850. doi: 10.1167/iovs.17-21597

Retinal Cell Biology July 2017

BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal

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Hiroyuki Sakagami; Osamu Katsumata; Yoshinobu Hara; Toshikuni Sasaoka; Masahiro Fukaya
TAGS: dystrophin, guanine nucleotide exchange factors, photoreceptors, antibodies, mice, proteins, retina, lysate, dystrophin-associated glycoprotein complex
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3795-3803. doi: 10.1167/iovs.17-21746

Includes: Supplemental Content

Cornea July 2017

Conditionally Immortal Slc4a11 −/− Mouse Corneal Endothelial Cell Line Recapitulates Disrupted Glutaminolysis Seen in Slc4a11 −/− Mouse Model

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Wenlin Zhang; Diego G. Ogando; Edward T. Kim; Moon-Jung Choi; Hongde Li; Jason M. Tenessen; Joseph A. Bonanno
TAGS: endothelial cells, viral tumor antigens, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3723-3731. doi: 10.1167/iovs.17-21781

Retinal Cell Biology July 2017

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency

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Saumya Nagar; Dorit Trudler; Scott R. McKercher; Juan Piña-Crespo; Nobuki Nakanishi; Shu-Ichi Okamoto; Stuart A. Lipton
TAGS: photoreceptors, mice, retina, myocyte-specific enhancer-binding factor 2, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3741-3749. doi: 10.1167/iovs.17-21767

Includes: Supplemental Content

Special Issue July 2017

Omics Biomarkers in Ophthalmology

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Susette Lauwen; Eiko K. de Jong; Dirk J. Lefeber; Anneke I. den Hollander
TAGS: glaucoma, biological markers, eye diseases, genome, myopia, ophthalmology, genetics, proteins
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO88-BIO98. doi: 10.1167/iovs.17-21809

Includes: Supplemental Content

Cornea July 2017

Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Miu Kitahara; Hirokazu Okuda; Keisuke Hashimoto; Emi Ueda; Makiko Nakahara; Shigeru Kinoshita; Robert D. Young; Andrew J. Quantock; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: apoptosis, polymerase chain reaction, mitochondria, cell death, hereditary corneal dystrophy, endothelium, corneal endothelium, tissue membrane, staurosporine, thapsigargin, cornea, proteins, stress, rna, small interfering, cyclophosphamide, doxorubicin, prednisone, and vincristine, chronic exertional compartment syndrome, unfolded protein response, mitochondrial membranes
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3697-3707. doi: 10.1167/iovs.16-21023

Includes: Supplemental Content

Article July 2017

Texture density adaptation can be bidirectional

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Hua-Chun Sun; Frederick A. A. Kingdom; Curtis L. Baker, Jr.
TAGS: perception, stairs, perceptual aftereffect
Journal of Vision. 2017; 17(8):9. doi: 10.1167/17.8.9

Genetics July 2017

Effects of Pathogenic Variations in the Human Rhodopsin Gene ( hRHO ) on the Predicted Accessibility for a Lead Candidate Ribozyme

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Beau R. Froebel; Alexandria J. Trujillo; Jack M. Sullivan
TAGS: mutation, genes, nucleotides, rhodopsin, catalytic rna, rna, messenger, cytokinesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3576-3591. doi: 10.1167/iovs.16-20877

Includes: Supplemental Content

Articles July 2017

Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye

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Justine R. Smith; Shawn Todd; Liam M. Ashander; Theodosia Charitou; Yuefang Ma; Steven Yeh; Ian Crozier; Michael Z. Michael; Binoy Appukuttan; Keryn A. Williams; David J. Lynn; Glenn A. Marsh
TAGS: ebola virus, infection, eye, retinal pigment cell
Trans. Vis. Sci. Tech.. 2017; 6(4):12. doi: 10.1167/tvst.6.4.12

Includes: Supplemental Content

Genetics July 2017

Caucasian Families Exhibit Significant Linkage of Myopia to Chromosome 11p

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Anthony M. Musolf; Claire L. Simpson; Bilal A. Moiz; Kyle A. Long; Laura Portas; Federico Murgia; Elise B. Ciner; Dwight Stambolian; Joan E. Bailey-Wilson
TAGS: chromosomes, family, genome, myopia, single nucleotide polymorphism, whites
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3547-3554. doi: 10.1167/iovs.16-21271

Includes: Supplemental Content

Genetics July 2017

Frequent GNAQ, GNA11 , and EIF1AX Mutations in Iris Melanoma

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Simone L. Scholz; Inga Möller; Henning Reis; Daniela Süßkind; Johannes A. P. van de Nes; Sonia Leonardelli; Bastian Schilling; Elisabeth Livingstone; Tobias Schimming; Annette Paschen; Antje Sucker; Rajmohan Murali; Klaus-Peter Steuhl; Dirk Schadendorf; Henrike Westekemper; Klaus G. Griewank
TAGS: mutation, neoplasms, bap1 gene, malignant melanoma of iris
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3464-3470. doi: 10.1167/iovs.17-21838

Includes: Supplemental Content

Cornea July 2017

TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus

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Muneeza Arbab; Saira Tahir; Muhammad Khizar Niazi; Mazhar Ishaq; Alamdar Hussain; Pir Muhammad Siddique; Sadia Saeed; Wajid Ali Khan; Raheel Qamar; Azeem Mehmood Butt; Maleeha Azam
TAGS: tumor necrosis factors, genetic predisposition to disease, keratoconus
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3481-3487. doi: 10.1167/iovs.16-21400

Articles July 2017

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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Anna P. Salvetti; Maria I. Patrício; Alun R. Barnard; Harry O. Orlans; Doron G. Hickey; Robert E. MacLaren
TAGS: gene therapy, cell survival, dyes, injection of therapeutic agent, surgical procedures, operative, toxic effect, spatial vectors
Trans. Vis. Sci. Tech.. 2017; 6(4):4. doi: 10.1167/tvst.6.4.4

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics July 2017

Alterations to the Foveal Cone Mosaic of Diabetic Patients

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Lucie Sawides; Kaitlyn A. Sapoznik; Alberto de Castro; Brittany R. Walker; Thomas J. Gast; Ann E. Elsner; Stephen A. Burns
TAGS: diabetes mellitus, retinal cone, diagnostic imaging, mosaicism
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3395-3403. doi: 10.1167/iovs.17-21793

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Peptide Nucleic Acid–Fluorescence In Situ Hybridization for Detection of Staphylococci From Endophthalmitis Isolates: A Proof-of-Concept Study

Novel Insights Into the Phenotypical Spectrum of KIF11 -Associated Retinopathy, Including a New Form of Retinal Ciliopathy

Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration

Leber's Hereditary Optic Neuropathy–Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India

β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

Choroidal Vasculature in Bietti Crystalline Dystrophy With CYP4V2 Mutations and in Retinitis Pigmentosa With EYS Mutations

C2orf71 Mutations as a Frequent Cause of Autosomal-Recessive Retinitis Pigmentosa: Clinical Analysis and Presentation of 8 Novel Mutations

BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal

Conditionally Immortal Slc4a11 −/− Mouse Corneal Endothelial Cell Line Recapitulates Disrupted Glutaminolysis Seen in Slc4a11 −/− Mouse Model

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency

Omics Biomarkers in Ophthalmology

Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy

Texture density adaptation can be bidirectional

Effects of Pathogenic Variations in the Human Rhodopsin Gene ( hRHO ) on the Predicted Accessibility for a Lead Candidate Ribozyme

Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye

Caucasian Families Exhibit Significant Linkage of Myopia to Chromosome 11p

Frequent GNAQ, GNA11 , and EIF1AX Mutations in Iris Melanoma

TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

Alterations to the Foveal Cone Mosaic of Diabetic Patients

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