Genetics

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Cornea July 2017

Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Miu Kitahara; Hirokazu Okuda; Keisuke Hashimoto; Emi Ueda; Makiko Nakahara; Shigeru Kinoshita; Robert D. Young; Andrew J. Quantock; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: apoptosis, polymerase chain reaction, mitochondria, cell death, hereditary corneal dystrophy, endothelium, corneal endothelium, tissue membrane, staurosporine, thapsigargin, cornea, proteins, stress, rna, small interfering, cyclophosphamide, doxorubicin, prednisone, and vincristine, chronic exertional compartment syndrome, unfolded protein response, mitochondrial membranes
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3697-3707. doi: 10.1167/iovs.16-21023

Includes: Supplemental Content

Article July 2017

Texture density adaptation can be bidirectional

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Hua-Chun Sun; Frederick A. A. Kingdom; Curtis L. Baker, Jr.
TAGS: perception, stairs, perceptual aftereffect
Journal of Vision. 2017; 17(8):9. doi: 10.1167/17.8.9

Genetics July 2017

Effects of Pathogenic Variations in the Human Rhodopsin Gene ( hRHO ) on the Predicted Accessibility for a Lead Candidate Ribozyme

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Beau R. Froebel; Alexandria J. Trujillo; Jack M. Sullivan
TAGS: mutation, genes, nucleotides, rhodopsin, catalytic rna, rna, messenger, cytokinesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3576-3591. doi: 10.1167/iovs.16-20877

Includes: Supplemental Content

Articles July 2017

Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye

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Justine R. Smith; Shawn Todd; Liam M. Ashander; Theodosia Charitou; Yuefang Ma; Steven Yeh; Ian Crozier; Michael Z. Michael; Binoy Appukuttan; Keryn A. Williams; David J. Lynn; Glenn A. Marsh
TAGS: ebola virus, infection, eye, retinal pigment cell
Trans. Vis. Sci. Tech.. 2017; 6(4):12. doi: 10.1167/tvst.6.4.12

Includes: Supplemental Content

Genetics July 2017

Caucasian Families Exhibit Significant Linkage of Myopia to Chromosome 11p

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Anthony M. Musolf; Claire L. Simpson; Bilal A. Moiz; Kyle A. Long; Laura Portas; Federico Murgia; Elise B. Ciner; Dwight Stambolian; Joan E. Bailey-Wilson
TAGS: chromosomes, family, genome, myopia, single nucleotide polymorphism, whites
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3547-3554. doi: 10.1167/iovs.16-21271

Includes: Supplemental Content

Genetics July 2017

Frequent GNAQ, GNA11 , and EIF1AX Mutations in Iris Melanoma

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Simone L. Scholz; Inga Möller; Henning Reis; Daniela Süßkind; Johannes A. P. van de Nes; Sonia Leonardelli; Bastian Schilling; Elisabeth Livingstone; Tobias Schimming; Annette Paschen; Antje Sucker; Rajmohan Murali; Klaus-Peter Steuhl; Dirk Schadendorf; Henrike Westekemper; Klaus G. Griewank
TAGS: mutation, neoplasms, bap1 gene, malignant melanoma of iris
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3464-3470. doi: 10.1167/iovs.17-21838

Includes: Supplemental Content

Cornea July 2017

TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus

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Muneeza Arbab; Saira Tahir; Muhammad Khizar Niazi; Mazhar Ishaq; Alamdar Hussain; Pir Muhammad Siddique; Sadia Saeed; Wajid Ali Khan; Raheel Qamar; Azeem Mehmood Butt; Maleeha Azam
TAGS: tumor necrosis factors, genetic predisposition to disease, keratoconus
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3481-3487. doi: 10.1167/iovs.16-21400

Articles July 2017

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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Anna P. Salvetti; Maria I. Patrício; Alun R. Barnard; Harry O. Orlans; Doron G. Hickey; Robert E. MacLaren
TAGS: gene therapy, cell survival, dyes, injection of therapeutic agent, surgical procedures, operative, toxic effect, spatial vectors
Trans. Vis. Sci. Tech.. 2017; 6(4):4. doi: 10.1167/tvst.6.4.4

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics July 2017

Alterations to the Foveal Cone Mosaic of Diabetic Patients

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Lucie Sawides; Kaitlyn A. Sapoznik; Alberto de Castro; Brittany R. Walker; Thomas J. Gast; Ann E. Elsner; Stephen A. Burns
TAGS: diabetes mellitus, retinal cone, diagnostic imaging, mosaicism
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3395-3403. doi: 10.1167/iovs.17-21793

Genetics July 2017

Screening of BEST1 Gene in a Chinese Cohort With Best Vitelliform Macular Dystrophy or Autosomal Recessive Bestrophinopathy

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Lu Tian; Tengyang Sun; Ke Xu; Xiaohui Zhang; Xiaoyan Peng; Yang Li
TAGS: mutation, cohort studies, genes, autosomal recessive inheritance, screening, vitelliform dystrophy, chinese people, chinese (other dialects)
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3366-3375. doi: 10.1167/iovs.17-21999

Includes: Supplemental Content

Cornea July 2017

The Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Cellular Senescence of Cultivated Human Corneal Endothelial Cells

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Akane Hongo; Naoki Okumura; Makiko Nakahara; EunDuck P. Kay; Noriko Koizumi
TAGS: aging, endothelial cells, cell aging, cornea, elderly, mitogen-activated protein kinase inhibitor, mitogen-activated protein kinase p38
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3325-3334. doi: 10.1167/iovs.16-21170

Includes: Supplemental Content

Articles July 2017

Light Modulates Ocular Complications in an Albino Rat Model of Type 1 Diabetes Mellitus

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Elias Andrawus; Gizi Veildbaum; Esther Zemel; Rina Leibu; Ido Perlman; Naim Shehadeh
TAGS: diabetes mellitus, albinism, diabetes mellitus, type 1, cataract, electroretinography, glial fibrillary acidic protein, rats, immunocytochemistry, white light, ocular complications
Trans. Vis. Sci. Tech.. 2017; 6(4):1. doi: 10.1167/tvst.6.4.1

Retina June 2017

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

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Freya M. Mowat; Kristen J. Gervais; Laurence M. Occelli; Matthew J. Annear; Janice Querubin; James W. Bainbridge; Alexander J. Smith; Robin R. Ali; Simon M. Petersen-Jones
TAGS: retinal cone, dog, domestic, opsin, photoreceptors, rod photoreceptors, eye, retina, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3268-3277. doi: 10.1167/iovs.17-21930

Special Issue June 2017

Oxidative Stress Measures of Lipid and DNA Damage in Human Tears

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Kristina M. Haworth; Heather L. Chandler
TAGS: oxidative stress, enzyme-linked immunosorbent assay, dna damage, conjunctiva, lipids, sun exposure, linear regression
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO151-BIO157. doi: 10.1167/iovs.17-21436

Cornea June 2017

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

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Doug D. Chung; Ricardo F. Frausto; Benjamin R. Lin; Evelyn M. Hanser; Zack Cohen; Anthony J. Aldave
TAGS: endothelium, genes, cornea, proteins, rna, polymorphous corneal dystrophy, zinc finger e-box-binding homeobox 1
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3202-3214. doi: 10.1167/iovs.17-21423

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2017

Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

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Elisabetta De Filippo; Prashiela Manga; Anke C. Schiedel
TAGS: albinism, ocular, arrestin, chinese hamster ovary cell, ethacridine, lactates, levodopa, ligands, melanins, melanocyte, monophenol monooxygenase, niclosamide, pimozide, pharmacology, proteins, g-protein-coupled receptors, x-linked inheritance, screening, lysate
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3118-3126. doi: 10.1167/iovs.16-21128

Includes: Supplemental Content

Retina June 2017

Reliability and Agreement Between Metrics of Cone Spacing in Adaptive Optics Images of the Human Retinal Photoreceptor Mosaic

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Daniela Giannini; Giuseppe Lombardo; Letizia Mariotti; Nicholas Devaney; Sebastiano Serrao; Marco Lombardo
TAGS: retinal cone, optics, photoreceptors, retinal diseases, mosaicism, reliability, chief complaint
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3127-3137. doi: 10.1167/iovs.16-20890

Includes: Supplemental Content

Genetics June 2017

Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase

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Marie H. Solheim; Allen C. Clermont; Jonathon N. Winnay; Erlend Hallstensen; Anders Molven; Pål R. Njølstad; Eyvind Rødahl; C. Ronald Kahn
TAGS: congenital abnormality, mutation, 1-phosphatidylinositol 3-kinase, eye, intraocular pressure, iris, mice, immune reconstitution inflammatory syndrome, short syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3100-3106. doi: 10.1167/iovs.16-21347

Includes: Supplemental Content

Cornea June 2017

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

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Jing Li; Szu-Yu Chen; Xin-Yue Zhao; Ming-Chang Zhang; Hua-Tao Xie
TAGS: signal transduction, western blotting, stem cells, epithelium, ligands, cornea, notch signaling pathway, dual antiplatelet therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2968-2976. doi: 10.1167/iovs.16-20642

Includes: Supplemental Content

Retinal Cell Biology June 2017

Overexpression of Angiotensin-Converting Enzyme 2 Ameliorates Amyloid β-Induced Inflammatory Response in Human Primary Retinal Pigment Epithelium

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Xinyu Fu; Ru Lin; Yiguo Qiu; Peng Yu; Bo Lei
TAGS: amyloid, apoptosis, cytokine, polymerase chain reaction, enzyme-linked immunosorbent assay, angiotensin-converting enzyme, inflammation, plasmids, monocyte chemoattractant protein-1, rna, messenger, proteins, antagonists, inflammatory response, protein overexpression, retinal pigment epithelium, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3018-3028. doi: 10.1167/iovs.17-21546

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Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy

Texture density adaptation can be bidirectional

Effects of Pathogenic Variations in the Human Rhodopsin Gene ( hRHO ) on the Predicted Accessibility for a Lead Candidate Ribozyme

Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye

Caucasian Families Exhibit Significant Linkage of Myopia to Chromosome 11p

Frequent GNAQ, GNA11 , and EIF1AX Mutations in Iris Melanoma

TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

Alterations to the Foveal Cone Mosaic of Diabetic Patients

Screening of BEST1 Gene in a Chinese Cohort With Best Vitelliform Macular Dystrophy or Autosomal Recessive Bestrophinopathy

The Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Cellular Senescence of Cultivated Human Corneal Endothelial Cells

Light Modulates Ocular Complications in an Albino Rat Model of Type 1 Diabetes Mellitus

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

Oxidative Stress Measures of Lipid and DNA Damage in Human Tears

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

Reliability and Agreement Between Metrics of Cone Spacing in Adaptive Optics Images of the Human Retinal Photoreceptor Mosaic

Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase

Rat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro

Overexpression of Angiotensin-Converting Enzyme 2 Ameliorates Amyloid β-Induced Inflammatory Response in Human Primary Retinal Pigment Epithelium

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