Immunology and Microbiology

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Biochemistry and Molecular Biology November 2022

An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration

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Robyn M. Biggs; Elisavet Makou; Scott Lauder; Andrew P. Herbert; Paul N. Barlow; Suresh K. Katti
TAGS: age-related macular degeneration, complement factor h, complement system proteins, hemolysis, proteins, immunoassay
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):30. doi: https://doi.org/10.1167/iovs.63.12.30

Includes: Supplemental Content

Genetics November 2022

Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy

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Huijing Ye; Anqi Sun; Wei Xiao; Te Zhang; Zhihui Xu; Lu Shi; Xiaotong Sha; Huasheng Yang
TAGS: circular rna, rna, messenger, graves' ophthalmopathy, connective tissue, genes, gene expression profiling
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):27. doi: https://doi.org/10.1167/iovs.63.12.27

Includes: Supplemental Content

Cornea & External Disease November 2022

Assessment of Keratitis Severity Using Quantitative Image Analysis in an In Vivo Murine Model of Staphylococcus aureus Bacterial Keratitis

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Tomas E. Meijome; Rachel Wozniak; Linda Kang; Lyna Azzouz; Leslie M. Niziol; William L. Johnson; Matthias Kriegel; Maria A. Woodward
TAGS: bacterial keratitis, infiltrates, keratitis, mice, staphylococcus aureus
Trans. Vis. Sci. Tech.. 2022; 11(11):12. doi: https://doi.org/10.1167/tvst.11.11.12

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit November 2022

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

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John P. M. Wood; Glyn Chidlow; Luke A. Halliday; Robert J. Casson; Dinesh Selva; Michelle Sun
TAGS: body tissue, langer-giedion syndrome, engineering
Trans. Vis. Sci. Tech.. 2022; 11(11):10. doi: https://doi.org/10.1167/tvst.11.11.10

Includes: Supplemental Content

Glaucoma November 2022

YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction

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Haiyan Li; Ayushi Singh; Kristin M. Perkumas; W. Daniel Stamer; Preethi S. Ganapathy; Samuel Herberg
TAGS: actins, cytoskeleton, hydrogel, hydrogels, pathophysiology, schlemm's canal, glaucoma, actomyosin, fibronectins, stress fibers
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):15. doi: https://doi.org/10.1167/iovs.63.12.15

Includes: Supplemental Content

Cornea November 2022

Conjunctiva Resident γδ T Cells Expressed High Level of IL-17A and Promoted the Severity of Dry Eye

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Ling Li; Yanxiao Li; Xinhao Zhu; Biao Wu; Zhuo Tang; Han Wen; Jianshu Yuan; Qinxiang Zheng; Wei Chen
TAGS: conjunctiva, dry eye syndromes, interleukin-17, mice, t-lymphocytes, ocular surfaces, internship and residency, medical residencies
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):13. doi: https://doi.org/10.1167/iovs.63.12.13

Includes: Supplemental Content

Cornea November 2022

Gallic Acid Ameliorates Aspergillus Fumigatus Keratitis Through Reducing Fungal Load and Suppressing the Inflammatory Response

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Songying Luan; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Jiao Yin; Junjie Luan; Xiaoyue Ji; Guiqiu Zhao
TAGS: aspergillus fumigatus, gallic acid, inflammation, inflammatory response, keratitis, mice, painful bladder syndrome, antifungal agents, natamycin
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):12. doi: https://doi.org/10.1167/iovs.63.12.12

Biochemistry and Molecular Biology October 2022

Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes

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Esma I. Yerlikaya; Allyson L. Toro; Siddharth Sunilkumar; Ashley M. VanCleave; Ming Leung; Yuka Imamura Kawasawa; Scot R. Kimball; Michael D. Dennis
TAGS: cytokine, diabetes mellitus, diabetes mellitus, type 2, syk kinase, vascular endothelial growth factor a, mice, hypoxia, neuroglia, retina, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):25. doi: https://doi.org/10.1167/iovs.63.11.25

Includes: Supplemental Content

Retina October 2022

Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema

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Nicholas J. Agard; Gu Zhang; John Ridgeway; Danielle M. Dicara; Phillip Y. Chu; Rachana Ohri; Sarah Sanowar; Jean-Michel Vernes; Hannah Chi; Jiameng Zhang; Emily Holz; Maciej Paluch; Guannan He; Yingjia Benson; Jianhuan Zhang; Pamela Chan; Nga Tang; Prachi Javale; Blair Wilson; Kathy Barrett; Rebecca K. Rowntree; Julie Hang; Y. Gloria Meng; Phil Hass; Germaine Fuh; Robert Piskol; Vladimir Bantseev; Kelly M. Loyet; John C. Tran; Cong Wu; Vahan B. Indjeian; Vittal Shivva; Minhong Yan
TAGS: agonists, diabetic macular edema, vasculature, antibodies
Trans. Vis. Sci. Tech.. 2022; 11(10):27. doi: https://doi.org/10.1167/tvst.11.10.27

Includes: Supplemental Content

Cornea & External Disease October 2022

Corneal Neuro-Regenerative Effect of Transcutaneous Electrical Stimulation in Rabbit Lamellar Keratectomy Model

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Young-Sik Yoo; Sera Park; Pyeonghwa Eun; Young Min Park; Dong Hui Lim; Tae-Young Chung
TAGS: cornea, electric stimulation, keratectomy, oryctolagus cuniculus, superior limbic keratoconjunctivitis, transcutaneous electric nerve stimulation, proteins, wound healing
Trans. Vis. Sci. Tech.. 2022; 11(10):17. doi: https://doi.org/10.1167/tvst.11.10.17

Cornea & External Disease October 2022

The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation

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Tsung-Chuan Ho; Nai-Wen Fan; Shu-I Yeh; Show-Li Chen; Yeou-Ping Tsao
TAGS: dry eye syndromes, gelatinase b, inflammation, mice, peptides, cornea, ocular surfaces
Trans. Vis. Sci. Tech.. 2022; 11(10):12. doi: https://doi.org/10.1167/tvst.11.10.12

Cornea October 2022

TGF-β–Mediated Modulation of Cell–Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells

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Kim Santerre; Sergio Cortez Ghio; Stéphanie Proulx
TAGS: chronic exertional compartment syndrome, cornea, endothelial cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):3. doi: https://doi.org/10.1167/iovs.63.11.3

Includes: Supplemental Content

Cornea October 2022

Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani -Induced Keratitis via the NF-κB Signaling Pathway

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Hanfeng Tang; Liwei Huang; Jianzhang Hu
TAGS: acute erythroblastic leukemia, cornea, fungal keratitis, fusarium solani, inflammation, inflammatory response, keratitis, methyltransferase, mice, signal pathway
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):2. doi: https://doi.org/10.1167/iovs.63.11.2

Includes: Supplemental Content

Cornea & External Disease September 2022

Role of Monocytes/Macrophages in the Etiology of Bullous Keratopathy After Argon Laser Iridotomy

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Satoru Yamagami; Seiichi Yokoo
TAGS: anterior segment of eye incision, argon lasers, bullous keratopathy, iris, laser iridotomy, macrophages, monocytes, lasers, leukocytes, cornea
Trans. Vis. Sci. Tech.. 2022; 11(9):33. doi: https://doi.org/10.1167/tvst.11.9.33

Includes: Supplemental Content

Cornea September 2022

METTL3 Attenuates Inflammation in Fusarium solani –Induced Keratitis via the PI3K/AKT Signaling Pathway

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Liwei Huang; Hanfeng Tang; Jianzhang Hu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, cornea, inflammation, keratitis, mice, signal pathway, signal transduction pathways, fusarium solani, infections
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):20. doi: https://doi.org/10.1167/iovs.63.10.20

Physiology and Pharmacology September 2022

Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes

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Jong Yeon Lee; Jingyi Wu; Yameng Liu; Sindhu Saraswathy; Longfang Zhou; Qianwen Bu; Ying Su; Dongwon Choi; Eunkyung Park; Clemens A. Strohmaier; Robert N. Weinreb; Young-Kwon Hong; Xiaojing Pan; Alex S. Huang
TAGS: eye, lymphatic vessels, metabolites, mice, oryctolagus cuniculus, vascular endothelial growth factor c, injections, lymphatic system, blister
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):16. doi: https://doi.org/10.1167/iovs.63.10.16

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2022

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

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Jiale Diao; Xinxin Chen; Pei Mou; Xiaoye Ma; Ruili Wei
TAGS: berberine, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, inflammation, western blotting, proteins, enzyme-linked immunosorbent assay, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):6. doi: https://doi.org/10.1167/iovs.63.10.6

Includes: Supplemental Content

Retina September 2022

Loss of Fas Receptor Function Preserves Photoreceptor Structure and Function in Two Mouse Models of Inherited Retinal Degeneration

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Jingyu Yao; Tiantian Wang; Lin Jia; Yaoyan Qiu; David N. Zacks
TAGS: cd95 antigens, mice, photoreceptors, retina, retinal degeneration, cytokine, inflammation, caspase-8
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):5. doi: https://doi.org/10.1167/iovs.63.10.5

Immunology and Microbiology August 2022

Topical Glaucoma Therapy Is Associated With Alterations of the Ocular Surface Microbiome

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Chih-Chiun J. Chang; Karina Somohano; Christine Zemsky; Anne-Catrin Uhlemann; Jeffrey Liebmann; George A. Cioffi; Lama A. Al-Aswad; Susan V. Lynch; Bryan J. Winn
TAGS: eye, eyedrops, glaucoma, microbiome, ocular surfaces
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):32. doi: https://doi.org/10.1167/iovs.63.9.32

Includes: Supplemental Content

Retina August 2022

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

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Yida Jiang; Li-Juan Duan; Jingbo Pi; Yun-Zheng Le; Guo-Hua Fong
TAGS: body tissue, heme, mice, oxidative stress, oxygenases, painful bladder syndrome, personal integrity, retinal pigment cell, retinal pigment epithelium, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):30. doi: https://doi.org/10.1167/iovs.63.9.30

Includes: Supplemental Content

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An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration

Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy

Assessment of Keratitis Severity Using Quantitative Image Analysis in an In Vivo Murine Model of Staphylococcus aureus Bacterial Keratitis

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction

Conjunctiva Resident γδ T Cells Expressed High Level of IL-17A and Promoted the Severity of Dry Eye

Gallic Acid Ameliorates Aspergillus Fumigatus Keratitis Through Reducing Fungal Load and Suppressing the Inflammatory Response

Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes

Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema

Corneal Neuro-Regenerative Effect of Transcutaneous Electrical Stimulation in Rabbit Lamellar Keratectomy Model

The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation

TGF-β–Mediated Modulation of Cell–Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells

Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani -Induced Keratitis via the NF-κB Signaling Pathway

Role of Monocytes/Macrophages in the Etiology of Bullous Keratopathy After Argon Laser Iridotomy

METTL3 Attenuates Inflammation in Fusarium solani –Induced Keratitis via the PI3K/AKT Signaling Pathway

Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

Loss of Fas Receptor Function Preserves Photoreceptor Structure and Function in Two Mouse Models of Inherited Retinal Degeneration

Topical Glaucoma Therapy Is Associated With Alterations of the Ocular Surface Microbiome

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

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