Immunology and Microbiology

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Biochemistry and Molecular Biology May 2021

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

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Salut Alba-Arbalat; Magi Andorra; Bernardo Sanchez-Dalmau; Anna Camos-Carreras; Marina Dotti-Boada; Irene Pulido-Valdeolivas; Sara Llufriu; Yolanda Blanco; Maria Sepulveda; Albert Saiz; Oscar Batet; Iker Bilbao; Iratxe Torre; Ivan Amat-Roldan; Elena H. Martinez-Lapiscina; Pablo Villoslada
TAGS: molecule, multiple sclerosis, retina, spectrum analysis, raman
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):11. doi: https://doi.org/10.1167/iovs.62.6.11

Includes: Supplemental Content

Cornea May 2021

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy

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Xintian Liu; Shuo Xu; Yingbin Wang; Xin Jin; Yan Shi; Hong Zhang
TAGS: atypical, cornea, epithelial cells, eye, herpes zoster ophthalmicus, keratitis, herpetic, microscopy, confocal, neurons, stem cells, nose
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):12. doi: https://doi.org/10.1167/iovs.62.6.12

Articles May 2021

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

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Eduardo Rodríguez-Bocanegra; Fabian Wozar; Immanuel P. Seitz; Felix F. L. Reichel; Alex Ochakovski; Kirsten Bucher; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: adeno-associated virus, eye, gene therapy, injections, primates, retina, spectral domain-optical coherence tomography, surgical procedures, operative, microglia
Trans. Vis. Sci. Tech.. 2021; 10(6):15. doi: https://doi.org/10.1167/tvst.10.6.15

Includes: Supplemental Content

Cornea May 2021

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

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Chenyang Dai; Rao Me; Nan Gao; Guanyu Su; Xinyi Wu; Fu-Shin X. Yu
TAGS: cornea, keratitis, mice, signal transduction, fungal keratitis, cytokine, infections, candida albicans, interleukin-33
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):10. doi: https://doi.org/10.1167/iovs.62.6.10

Articles May 2021

Lactobacillus sakei Pro-Bio65 Reduces TNF-α Expression and Upregulates GSH Content and Antioxidant Enzymatic Activities in Human Conjunctival Cells

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Roberto Iorio; Sabrina Petricca; Carla Luzi; Pierangelo Bellio; Loredana Cristiano; Claudio Festuccia; Gianfranco Amicosante; Giuseppe Celenza
TAGS: antioxidants, conjunctiva, lactobacillus sakei, tumor necrosis factors, mitochondria
Trans. Vis. Sci. Tech.. 2021; 10(6):8. doi: https://doi.org/10.1167/tvst.10.6.8

Articles May 2021

Longitudinal Study of Retinal Structure, Vascular, and Neuronal Function in Patients With Relapsing-Remitting Multiple Sclerosis: 1-Year Follow-Up

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Qi Chen; Hong Jiang; Silvia Delgado; Jeffrey Hernandez; Diego Eduardo Alba; Giovanni Gregori; Kottil W. Rammohan; Vittorio Porciatti; Jianhua Wang
TAGS: follow-up, longitudinal studies, multiple sclerosis, relapsing-remitting, retina, eye, medical history
Trans. Vis. Sci. Tech.. 2021; 10(6):6. doi: https://doi.org/10.1167/tvst.10.6.6

Clinical and Epidemiologic Research May 2021

Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy

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Luca D'Onofrio; Alise Kalteniece; Maryam Ferdousi; Shazli Azmi; Ioannis N. Petropoulos; Georgios Ponirakis; Uazman Alam; Omar Asghar; Andrew Marshall; Andrew J.M. Boulton; Nathan Efron; Raffaella Buzzetti; Handrean Soran; Rayaz A. Malik
TAGS: anterior descending branch of left coronary artery, cornea, diabetes mellitus, type 2, langerhans cell, microscopy, confocal, nerve fibers, neurons, nervousness
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):5. doi: https://doi.org/10.1167/iovs.62.6.5

Articles April 2021

Abnormal Dynamic Pupillometry Relates to Neurologic Disability and Retinal Axonal Loss in Patients With Multiple Sclerosis

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Gulfidan Bitirgen; Zehra Akpinar; Huseyin B. Turk; Rayaz A. Malik
TAGS: disability, multiple sclerosis, pupil reaction, pupillometry, medical history, pupil light reflex, retinal nerve fiber layer, pupil
Trans. Vis. Sci. Tech.. 2021; 10(4):30. doi: https://doi.org/10.1167/tvst.10.4.30

Articles April 2021

Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil

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Keisuke Watanabe; Masataka Yoshida; Takashi Okumura; Takayuki Sassa; Akio Kihara; Akira Uchiyama
TAGS: dry eye syndromes, meibomian gland dysfunction, mice, mineral oil, ophthalmic solutions, meibomian gland
Trans. Vis. Sci. Tech.. 2021; 10(4):21. doi: https://doi.org/10.1167/tvst.10.4.21

Articles April 2021

Corneal Immune Cells Are Increased in Patients With Multiple Sclerosis

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Adnan Khan; Yi Li; Georgios Ponirakis; Naveed Akhtar; Hoda Gad; Pooja George; Faiza M. Ibrahim; Ioannis N. Petropoulos; Beatriz G. Canibano; Dirk Deleu; Ashfaq Shuaib; Saadat Kamran; Rayaz A. Malik
TAGS: cornea, multiple sclerosis, neurons, ciliary motility disorders, multiple sclerosis, relapsing-remitting, microscopy, confocal
Trans. Vis. Sci. Tech.. 2021; 10(4):19. doi: https://doi.org/10.1167/tvst.10.4.19

Retinal Cell Biology April 2021

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

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Yi Chen; Binxin Wu; Jian Feng He; Jingyao Chen; Zi Wei Kang; Dandan Liu; Junjie Luo; Kexin Fang; Xiaoxu Leng; Haibin Tian; Jingying Xu; Caixia Jin; Jieping Zhang; Juan Wang; Jingfa Zhang; Qingjian Ou; Lixia Lu; Furong Gao; Guo-Tong Xu
TAGS: epithelial to mesenchymal transition, retinal pigment cell, signal transduction inhibitor, primary eosinophilic endomyocardial cardiomyopathy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):21. doi: https://doi.org/10.1167/iovs.62.4.21

Includes: Supplemental Content

Cornea April 2021

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

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Yawen Niu; Changjie Ren; Xudong Peng; Cui Li; Qiang Xu; Liting Hu; Ziyue Zhang; Guiqiu Zhao; Jing Lin
TAGS: aspergillus fumigatus, cornea, cytokine, keratitis, macrophages, mice, proteins, interleukin-6, rna, messenger, infections
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):16. doi: https://doi.org/10.1167/iovs.62.4.16

Articles April 2021

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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Fumihito Hikage; Yosuke Ida; Yuika Ouchi; Megumi Watanabe; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins
Trans. Vis. Sci. Tech.. 2021; 10(4):6. doi: https://doi.org/10.1167/tvst.10.4.6

Includes: Supplemental Content

Cornea April 2021

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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Yong Woo Ji; Hyun Goo Kang; Jong Suk Song; Ji Won Jun; Kyusun Han; Tae-im Kim; Kyoung Yul Seo; Hyung Keun Lee
TAGS: dopamine, dopamine receptors, dry eye syndromes, langer-giedion syndrome, mice, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):14. doi: https://doi.org/10.1167/iovs.62.4.14

Articles April 2021

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

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Guangqi An; Fangfang Dai; Rui Wang; Zhenhui Liu; Ju Guo; Meng Pan; Xuemin Jin; Bo Lei
TAGS: 3d mri, eye, myopia, risk factors, staphyloma, shape
Trans. Vis. Sci. Tech.. 2021; 10(4):5. doi: https://doi.org/10.1167/tvst.10.4.5

Retina April 2021

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

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Balasubramaniam Annamalai; Nathaniel Parsons; Crystal Nicholson; Elisabeth Obert; Bryan Jones; Bärbel Rohrer
TAGS: complement system proteins, familial hypercholesterolemia, family history, mice, adeno-associated virus
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):11. doi: https://doi.org/10.1167/iovs.62.4.11

Visual Neuroscience April 2021

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

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Qian Wu; Hao Hu; Wen Chen; Huan-Huan Chen; Lu Chen; Jiang Zhou; Hu Liu; Fei-Yun Wu; Xiao-Quan Xu
TAGS: brain, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):5. doi: https://doi.org/10.1167/iovs.62.4.5

Includes: Supplemental Content

Glaucoma April 2021

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression

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Vidhya R. Rao; Evan B. Stubbs, Jr
TAGS: nadph oxidase 4, oxidative stress, proteins, trabecular meshwork, nadph oxidases, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):4. doi: https://doi.org/10.1167/iovs.62.4.4

Review April 2021

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

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Ying Kai Chan; Andrew D. Dick; Sara Mary Hall; Thomas Langmann; Curtis L. Scribner; Brian C. Mansfield; for the Ocular Gene Therapy Inflammation Working Group
TAGS: blindness, gene therapy, inflammation, spatial vectors, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(4):3. doi: https://doi.org/10.1167/tvst.10.4.3

Cornea March 2021

Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines

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Xue Tian; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Jiao Yin; Ranran Zhang; Guiqiu Zhao
TAGS: antifungal agents, anti-inflammatory agents, cytokine, keratitis, mice, pattern recognition receptors, aspergillus fumigatus, dimethyl sulfoxide, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):38. doi: https://doi.org/10.1167/iovs.62.3.38

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In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

Lactobacillus sakei Pro-Bio65 Reduces TNF-α Expression and Upregulates GSH Content and Antioxidant Enzymatic Activities in Human Conjunctival Cells

Longitudinal Study of Retinal Structure, Vascular, and Neuronal Function in Patients With Relapsing-Remitting Multiple Sclerosis: 1-Year Follow-Up

Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy

Abnormal Dynamic Pupillometry Relates to Neurologic Disability and Retinal Axonal Loss in Patients With Multiple Sclerosis

Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil

Corneal Immune Cells Are Increased in Patients With Multiple Sclerosis

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines

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