Immunology and Microbiology

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Article October 2021

ImageNet-trained deep neural networks exhibit illusion-like response to the Scintillating grid

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Eric D. Sun; Ron Dekel
TAGS: illusions, luminance
Journal of Vision. 2021; 21(11):15. doi: https://doi.org/10.1167/jov.21.11.15

Includes: Supplemental Content

Retina October 2021

Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model

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Tine Van Bergen; Tjing-Tjing Hu; Karis Little; Lies De Groef; Lieve Moons; Alan W. Stitt; Elke Vermassen; Jean H. M. Feyen
TAGS: diabetes mellitus, plasma kallikrein, eye, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):18. doi: https://doi.org/10.1167/iovs.62.13.18

Retina October 2021

Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1 + Macrophage Infiltration

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Iori Wada; Shintaro Nakao; Muneo Yamaguchi; Yoshihiro Kaizu; Mitsuru Arima; Shinichiro Sawa; Koh-Hei Sonoda
TAGS: diabetic retinopathy, lymphangiogenesis, lymphatic vessels, macrophages, mice, protein overexpression, retina, vascular endothelial growth factor a, vascular endothelial growth factor c, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):17. doi: https://doi.org/10.1167/iovs.62.13.17

Includes: Supplemental Content

Retinal Cell Biology October 2021

Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy

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Emma M. Lessieur; Haitao Liu; Aicha Saadane; Yunpeng Du; Jie Tang; Jianying Kiser; Timothy S. Kern
TAGS: cytotoxicity, diabetes mellitus, endopeptidases, endothelial cells, leukocytes, mice, neutrophils, peptide hydrolases, superoxides, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):7. doi: https://doi.org/10.1167/iovs.62.13.7

Includes: Supplemental Content

Cornea October 2021

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

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Hua Chen; Hui Gao; Hua-Tao Xie; Shu-Ting Liu; Yu-Kan Huang; Ming-Chang Zhang
TAGS: cytokine, meibomian gland, mice, staphylococcus aureus, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):11. doi: https://doi.org/10.1167/iovs.62.13.11

Cornea October 2021

Local Renin-Angiotensin System Activation and Myofibroblast Formation in Graft Versus Host Disease–Associated Conjunctival Fibrosis

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Kiumars Shamloo; Judy Weng; Christopher Ross; Jenni Lee; Saleh Alfuraih; Jennifer Totonchy; Ajay Sharma
TAGS: conjunctiva, fibrosis, graft-versus-host disease, myofibroblasts, renin-angiotensin system, mice, transplantation, homologous
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):10. doi: https://doi.org/10.1167/iovs.62.13.10

Includes: Supplemental Content

Special Issue October 2021

One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration

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Amir H. Kashani; Jane S. Lebkowski; Firas M. Rahhal; Robert L. Avery; Hani Salehi-Had; Sanford Chen; Clement Chan; Neal Palejwala; April Ingram; Wei Dang; Chih-Min Lin; Debbie Mitra; Britney O. Pennington; Cassidy Hinman; Mohamed A. Faynus; Jeffrey K. Bailey; Sukriti Mohan; Narsing Rao; Lincoln V. Johnson; Dennis O. Clegg; David R. Hinton; Mark S. Humayun
TAGS: age-related macular degeneration, follow-up, implants, retinal pigment cell, surgical procedures, operative, postoperative care, therapeutic immunosuppression
Trans. Vis. Sci. Tech.. 2021; 10(10):13. doi: https://doi.org/10.1167/tvst.10.10.13

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology September 2021

Novel Foveal Features Associated With Vision Impairment in Multiple Sclerosis

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Aubrey Hargrave; Nripun Sredar; Fareshta Khushzad; Jennifer Yarp; Anna Tomczak; May Han; Lucas Kipp; Alfredo Dubra; Heather E. Moss
TAGS: diagnostic imaging, eye, multiple sclerosis, visual impairment, retina, vision, retinal nerve fiber layer, ganglia
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):27. doi: https://doi.org/10.1167/iovs.62.12.27

Retina September 2021

Vitreous M2 Macrophage-Derived Microparticles Promote RPE Cell Proliferation and Migration in Traumatic Proliferative Vitreoretinopathy

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Yinting Song; Mengyu Liao; Xiao Zhao; Han Han; Xue Dong; Xiaohong Wang; Mei Du; Hua Yan
TAGS: macrophages, massively-parallel genome sequencing, mucopolysaccharidoses, retinal pigment cell, vitreous body, cell-derived microparticles, vitreoretinopathy, proliferative
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):26. doi: https://doi.org/10.1167/iovs.62.12.26

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2021

Effects of Aging on Human Meibum

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Igor A. Butovich; Tomo Suzuki
TAGS: aging, lipids, significance, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):23. doi: https://doi.org/10.1167/iovs.62.12.23

Includes: Supplemental Content

Retina September 2021

CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X 7 in the Diabetic Retina

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Jin-Sang Yu; Jad Daw; Jose-Andres C. Portillo; Carlos S. Subauste
TAGS: cd40 antigens, diabetes mellitus, endothelial cells, intercellular adhesion molecule 1, retina, up-regulation (physiology), tumor necrosis factors, cytokine, diabetic retinopathy, mice
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):22. doi: https://doi.org/10.1167/iovs.62.12.22

Biochemistry and Molecular Biology September 2021

The Potential Role of Osteopontin in the Pathogenesis of Graves’ Ophthalmopathy

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Heng Lou; Lian-Qun Wu; Hao Wang; Rui-Li Wei; Jin-Wei Cheng
TAGS: collagen, connective tissue, cytokine, graves' ophthalmopathy, osteopontin, pathogenesis, proteins, rna, messenger, cd40 ligand, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):18. doi: https://doi.org/10.1167/iovs.62.12.18

Cornea September 2021

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy

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Rajalekshmy Shyam; Diego G. Ogando; Moonjung Choi; Paloma B. Liton; Joseph A. Bonanno
TAGS: animal model, autophagy, cornea, endothelial cells, endothelium, impairment, mitochondria, mitoq compound, pathophysiology, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):15. doi: https://doi.org/10.1167/iovs.62.12.15

Includes: Supplemental Content

Immunology and Microbiology September 2021

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

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Zhang Zhang; Xinrong Zou; Wenwen Xue; Pei Zhang; Shanshan Wang; Haidong Zou
TAGS: diabetes mellitus, dry eye syndromes, microbiome
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):13. doi: https://doi.org/10.1167/iovs.62.12.13

Includes: Supplemental Content

Cornea September 2021

Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal Endothelium

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Moonjung Choi; Joseph A. Bonanno
TAGS: hsp90 heat-shock proteins, mitochondria, molecular chaperones, ammonia
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):4. doi: https://doi.org/10.1167/iovs.62.12.4

Includes: Supplemental Content

Clinical Trials September 2021

Characteristics of Toxic Keratopathy, an In Vivo Confocal Microscopy Study

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Leying Wang; Yang Zhang; Zhenyu Wei; Kai Cao; Guanyu Su; Pedram Hamrah; Antoine Labbe; Qingfeng Liang
TAGS: basal cells, cornea, keratocytes, microscopy, confocal, neurons, finnish congenital nephrotic syndrome, slit lamps, eyedrops, signs and symptoms
Trans. Vis. Sci. Tech.. 2021; 10(11):11. doi: https://doi.org/10.1167/tvst.10.11.11

Includes: Supplemental Content

Cornea September 2021

Changes in Conjunctival Microbiota Associated With HIV Infection and Antiretroviral Therapy

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Qun Liu; Zhi-Yi Xu; Xiao-Li Wang; Xiao-Mei Huang; Wen-Lin Zheng; Mei-Jun Li; Fan Xiao; Pei-Wen Ouyang; Xiao-Hua Yang; Yu-Hong Cui; Hong-Wei Pan
TAGS: anti-retroviral agents, antiretroviral therapy, highly active, conjunctiva, hiv infections, microbiome, did not receive therapy or drug, hiv, hiv seropositivity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):1. doi: https://doi.org/10.1167/iovs.62.12.1

Articles August 2021

Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis

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Elena Koudouna; Marcela Huertas-Bello; Cristian Nicolas Rodriguez; Sandra Consuelo Henao; Myriam Lucia Navarrete; Marcel Yecid Avila
TAGS: cornea, keratitis, fungal keratitis, suidae
Trans. Vis. Sci. Tech.. 2021; 10(9):31. doi: https://doi.org/10.1167/tvst.10.9.31

Includes: Supplemental Content

Articles August 2021

Predictive Accuracy and Densitometric Analysis of Point-of-Care Immunoassay for Adenoviral Conjunctivitis

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Spencer D. Johnson; Jennifer S. Harthan; Tammy Than; Mary K. Migneco; Ellen Shorter; Meredith M. Whiteside; Christina E. Morettin; Christian K. Olson; Crystal A. Rosemann; Mathew S. Margolis; Leonard W. Haertter; Julia B. Huecker; Bojana Rodic-Polic; Richard S. Buller; Gregory A. Storch; Mae O. Gordon; Andrew T. E. Hartwick
TAGS: adenoviral conjunctivitis, adenoviruses, densitometry, immunoassay, eye, laboratory test finding
Trans. Vis. Sci. Tech.. 2021; 10(9):30. doi: https://doi.org/10.1167/tvst.10.9.30

Includes: Supplemental Content

Immunology and Microbiology August 2021

Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes

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Shalem Raj Padakandla; Taraprasad Das; Gumpili Sai Prashanthi; Kiran Kumar Angadi; S. Sreenivasa Reddy; G. Bhanuprakash Reddy; Sisinthy Shivaji
TAGS: diabetes mellitus, intestinal bacteria, microbiome, rats, streptozocin, dysbiosis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):31. doi: https://doi.org/10.1167/iovs.62.10.31

Includes: Supplemental Content

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ImageNet-trained deep neural networks exhibit illusion-like response to the Scintillating grid

Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model

Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1 + Macrophage Infiltration

Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

Local Renin-Angiotensin System Activation and Myofibroblast Formation in Graft Versus Host Disease–Associated Conjunctival Fibrosis

One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration

Novel Foveal Features Associated With Vision Impairment in Multiple Sclerosis

Vitreous M2 Macrophage-Derived Microparticles Promote RPE Cell Proliferation and Migration in Traumatic Proliferative Vitreoretinopathy

Effects of Aging on Human Meibum

CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X 7 in the Diabetic Retina

The Potential Role of Osteopontin in the Pathogenesis of Graves’ Ophthalmopathy

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal Endothelium

Characteristics of Toxic Keratopathy, an In Vivo Confocal Microscopy Study

Changes in Conjunctival Microbiota Associated With HIV Infection and Antiretroviral Therapy

Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis

Predictive Accuracy and Densitometric Analysis of Point-of-Care Immunoassay for Adenoviral Conjunctivitis

Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes

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