Immunology and Microbiology

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Physiology and Pharmacology November 2019

Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization

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Samy Omri; Houda Tahiri; Wyston Chadwick Pierre; Michel Desjarlais; Isabelle Lahaie; Sarah-Eve Loiselle; Flavio Rezende; Gregory Lodygensky; Terence E. Hebert; Huy Ong; Sylvain Chemtob
TAGS: choroidal neovascularization, propranolol, reticuloendothelial system, macrophages, angiogenesis
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4632-4642. doi: https://doi.org/10.1167/iovs.18-25502

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2019

Characterization of LSD1 Expression Within the Murine Eye

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Salma Ferdous; Hans E. Grossniklaus; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4619-4631. doi: https://doi.org/10.1167/iovs.19-26728

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2019

Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration

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Nana Xu; Qiyu Bo; Rong Shao; Jian Liang; Yuanqi Zhai; Shiqi Yang; Fenghua Wang; Xiaodong Sun
TAGS: chitinase-3-like protein 1, choroidal neovascularization, macrophages, angiogenesis, exudative age-related macular degeneration, chitinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4596-4605. doi: https://doi.org/10.1167/iovs.19-27493

Includes: Supplemental Content

Cornea November 2019

Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue

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Kiumars Shamloo; Ashley Barbarino; Saleh Alfuraih; Ajay Sharma
TAGS: cornea, dry eye syndromes, graft-versus-host disease, mucins, rebamipide, secretagogues, mice, tissue transplants, tear film finding, transplantation, homologous
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4511-4519. doi: https://doi.org/10.1167/iovs.19-27843

Lecture October 2019

The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture

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Jerry Y. Niederkorn
TAGS: cornea, eye, immune privilege, immune system, nerve ablation, allografting, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4489-4495. doi: https://doi.org/10.1167/iovs.19-28632

Retinal Cell Biology October 2019

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration

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Miyuki Murata; Kousuke Noda; Shiho Yoshida; Michiyuki Saito; Akio Fujiya; Atsuhiro Kanda; Susumu Ishida
TAGS: acrolein, chemokine (c-x-c motif) ligand 1, neuroglia, aldehydes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4425-4435. doi: https://doi.org/10.1167/iovs.19-27346

Includes: Supplemental Content

Retinal Cell Biology October 2019

Creatine is Neuroprotective to Retinal Neurons In Vitro But Not In Vivo

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Paul Ikgan Sia; John P. M. Wood; Glyn Chidlow; Robert Casson
TAGS: creatine
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4360-4377. doi: https://doi.org/10.1167/iovs.18-25858

Includes: Supplemental Content

Glaucoma October 2019

Extracellular Signal-Regulated Kinase 1/2 Pathway Is Insufficiently Involved in the Neuroprotective Effect by Hydrogen Sulfide Supplement in Experimental Glaucoma

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Shouyue Huang; Ping Huang; Huan Yu; Zhongjing Lin; Xiaohong Liu; Xi Shen; Lei Guo; Yisheng Zhong
TAGS: glaucoma, hydrogen sulfide, neuroprotective effect, phosphotransferases, rats, tumor necrosis factors, western blotting, proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4346-4359. doi: https://doi.org/10.1167/iovs.19-27507

Biochemistry and Molecular Biology October 2019

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

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Collynn F. Woeller; Elisa Roztocil; Christine Hammond; Steven E. Feldon
TAGS: micrornas, phosphoinositide 3-kinase, proto-oncogene proteins c-akt, signal transduction, thyrotropin, thyrotropin receptor, fibroblasts, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4336-4345. doi: https://doi.org/10.1167/iovs.19-27865

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2019

Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

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Huiling Hu; Hong Jiang; Giovana Rosa Gameiro; Jeffrey Hernandez; Silvia Delgado; Jianhua Wang
TAGS: eye, ganglia, maps, medical history, multiple sclerosis, optic neuritis, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4257-4269. doi: https://doi.org/10.1167/iovs.19-27574

Cornea October 2019

Stimulation of Phagocytic Activity in Cultured Human Corneal Fibroblasts by Plasminogen

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Tomoko Sato; Koji Sugioka; Aya Kodama-Takahashi; Junko Murakami; Akio Saito; Hiroshi Mishima; Teruo Nishida; Shunji Kusaka
TAGS: cornea, fibroblasts, plasminogen, phagocytosis, cell-derived microparticles
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4205-4214. doi: https://doi.org/10.1167/iovs.19-27736

Retina October 2019

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway

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Chufeng Gu; Deji Draga; Chuandi Zhou; Tong Su; Chen Zou; Qing Gu; Tashi Lahm; Zhi Zheng; Qinghua Qiu
TAGS: diabetic retinopathy, nadph oxidase 4, pyroptosis, caspase-1, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4215-4223. doi: https://doi.org/10.1167/iovs.19-27825

Includes: Supplemental Content

Cornea October 2019

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

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Changjun Wang; Laura Schaefer; Fang Bian; Zhiyuan Yu; Stephen C. Pflugfelder; Robert A. Britton; Cintia S. de Paiva
TAGS: antibiotics, dysbiosis, inflammatory response, mice, microbiome, conjunctiva, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4224-4233. doi: https://doi.org/10.1167/iovs.19-27939

Biochemistry and Molecular Biology October 2019

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

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Jihei Sara Lee; Jinjoo Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: curcumin, fibroblasts, polyphenols, plants
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4129-4140. doi: https://doi.org/10.1167/iovs.19-27376

Immunology and Microbiology September 2019

CCR6-Positive γδ T Cells Provide Protection Against Intracorneal HSV-1 Infection

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Steffani Fitzpatrick; Robert Lausch; Robert A. Barrington
TAGS: cornea, human herpesvirus 1, infection, t-lymphocytes, mice, interleukin-17
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3952-3962. doi: https://doi.org/10.1167/iovs.19-27810

Cornea September 2019

Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy

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Ziye Rong; Jiaxin Hu; David R. Corey; V. Vinod Mootha
TAGS: proteins, rna, cornea, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3980-3991. doi: https://doi.org/10.1167/iovs.19-27641

Includes: Supplemental Content

Genetics September 2019

MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus

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Ebony Liu; Georgia Kaidonis; Bennet J. McComish; Mark C. Gillies; Sotoodeh Abhary; Rohan W. Essex; John H. Chang; Bishwanath Pal; Mark Daniell; Stewart Lake; Nikolai Petrovsky; Alex W. Hewitt; Alicia Jenkins; Ecosse L. Lamoureux; Jonathan M. Gleadle; Jamie E. Craig; Kathryn P. Burdon
TAGS: diabetes mellitus, type 1, diabetic retinopathy, genes, genetics, micrornas, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3937-3942. doi: https://doi.org/10.1167/iovs.18-25570

Includes: Supplemental Content

Lens September 2019

Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

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Andrew J. O. Smith; Julie A. Eldred; I. Michael Wormstone
TAGS: lens, crystalline, resveratrol, wound healing, lens (device), after-cataract, prevention, fibrosis, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3863-3877. doi: https://doi.org/10.1167/iovs.18-26248

Articles September 2019

Comparative Study of Chemical Composition, Molecular and Rheological Properties of Silicone Oil Medical Devices

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Raniero Mendichi; Alberto Giacometti Schieroni; Daniele Piovani; Davide Allegrini; Mariantonia Ferrara; Mario R. Romano
TAGS: biocompatibility, comparative study research, devices, medical, molecular mass, silicone oils, spectrum analysis, viscosity, polymers
Trans. Vis. Sci. Tech.. 2019; 8(5):9. doi: https://doi.org/10.1167/tvst.8.5.9

Articles September 2019

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand

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Kathryn L. Pepple; Leslie Wilson; Russell N. Van Gelder; Marina Kovaleva; Obinna C. Ubah; John Steven; Caroline J. Barelle; Andrew Porter
TAGS: cytokine, inflammation, ligands, receptors, antigen, sharks, t-lymphocytes, tumor necrosis factor-alpha, uveitis, dexamethasone, eye
Trans. Vis. Sci. Tech.. 2019; 8(5):11. doi: https://doi.org/10.1167/tvst.8.5.11

Includes: Supplemental Content

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Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization

Characterization of LSD1 Expression Within the Murine Eye

Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration

Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue

The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration

Creatine is Neuroprotective to Retinal Neurons In Vitro But Not In Vivo

Extracellular Signal-Regulated Kinase 1/2 Pathway Is Insufficiently Involved in the Neuroprotective Effect by Hydrogen Sulfide Supplement in Experimental Glaucoma

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

Stimulation of Phagocytic Activity in Cultured Human Corneal Fibroblasts by Plasminogen

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

CCR6-Positive γδ T Cells Provide Protection Against Intracorneal HSV-1 Infection

Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy

MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus

Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

Comparative Study of Chemical Composition, Molecular and Rheological Properties of Silicone Oil Medical Devices

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand

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