Nanotechnology and Regenerative Medicine

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Cornea September 2023

Isolation and Characterization of Human Conjunctival Mesenchymal Stromal Cells and Their Extracellular Vesicles

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Laura García-Posadas; Ismael Romero-Castillo; Kieran Brennan; Margaret M. McGee; Alfonso Blanco-Fernández; Yolanda Diebold
TAGS: antioxidants, conjunctiva, extracellular vesicles, mesenchymal stem cells, patient isolation, social isolation, body tissue, flow cytometry, conjunctival epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):38. https://doi.org/10.1167/iovs.64.12.38

Includes: Supplemental Content

Physiology and Pharmacology August 2023

Discovery of CTSK + Periosteal Stem Cells Mediating Bone Repair in Orbital Reconstruction

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Zeyang Liu; Jin Liu; Jipeng Li; Yinwei Li; Jing Sun; Yuan Deng; Huifang Zhou
TAGS: orbital reconstruction, osteoplasty, periosteum, stem cells, zygomatic bones, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):30. https://doi.org/10.1167/iovs.64.11.30

Biochemistry and Molecular Biology August 2023

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy

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Hyeong Ju Byeon; Min Kyung Chae; JaeSang Ko; Eun Jig Lee; Don O. Kikkawa; Sun Young Jang; Jin Sook Yoon
TAGS: complement factor d, fibroblasts, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):13. https://doi.org/10.1167/iovs.64.11.13

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2023

Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization

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Jilu Jaffet; Aparna Mohanty; Induvahi Veernala; Swati Singh; Mohammad Javed Ali; Sayan Basu; Geeta K. Vemuganti; Vivek Singh
TAGS: lacrimal gland, langer-giedion syndrome, mesenchymal stem cells, patient isolation, social isolation, body tissue, gene expression, flow cytometry, fluorescent antibody technique, 5'-nucleotidase
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):12. https://doi.org/10.1167/iovs.64.10.12

Includes: Supplemental Content

Review June 2023

Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions

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Selina Drag; Farokh Dotiwala; Arun K. Upadhyay
TAGS: gene therapy
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):39. https://doi.org/10.1167/iovs.64.7.39

Biochemistry and Molecular Biology June 2023

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

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Yanyan Xie; Yuan Pan; Qian Chen; Yuxi Chen; Guanyu Chen; Mei Wang; Peng Zeng; Zhuang Li; Zuoyi Li; Sha Wang; Huasheng Yang; Dan Liang
TAGS: fibrosis, forkhead box protein m1, graves' ophthalmopathy, fibroblasts, proteins
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):9. https://doi.org/10.1167/iovs.64.7.9

Includes: Supplemental Content

Letters to the Editor May 2023

Letter to the Editor: Characterization of Choriocapillaris and Choroidal Abnormalities in Alport Syndrome

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Damir Bosnar; Mira Knežić Zagorec; Mladen Bušić; Valentina Cigić; Nikola Zagorec; Tamara Nikuševa Martić; Danica Galešić Ljubanović
TAGS: hereditary nephritis
Trans. Vis. Sci. Tech.. 2023; 12(5):25. https://doi.org/10.1167/tvst.12.5.25

Artificial Intelligence May 2023

Deep Learning Using Preoperative AS-OCT Predicts Graft Detachment in DMEK

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Alastair Patefield; Yanda Meng; Matteo Airaldi; Giulia Coco; Sabrina Vaccaro; Mohit Parekh; Francesco Semeraro; Kunal A. Gadhvi; Stephen B. Kaye; Yalin Zheng; Vito Romano
TAGS: deep learning, descemet membrane endothelial keratoplasty, preoperative care, tissue transplants
Trans. Vis. Sci. Tech.. 2023; 12(5):14. https://doi.org/10.1167/tvst.12.5.14

Cornea March 2023

Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty

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Ruixing Liu; Jingguo Li; Zhihua Guo; Dandan Chu; Chengcheng Li; Liuqi Shi; Junjie Zhang; Lei Zhu; Zhanrong Li
TAGS: cornea, descemet stripping endothelial keratoplasty, fibrosis, signal transduction, proteins, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):9. https://doi.org/10.1167/iovs.64.3.9

Glaucoma February 2023

ALK5 Inhibition of Subconjunctival Scarring From Glaucoma Surgery: Effects of SB-431542 Compared to Mitomycin C in Human Tenon's Capsule Fibroblasts

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Jack E. Teplitsky; Anastasiya Vinokurtseva; James J. Armstrong; James Denstedt; Hong Liu; Cindy M. L. Hutnik
TAGS: cicatrix, collagen, cytotoxicity, fibroblasts, glaucoma surgery, mitomycin, proteins, tenon's capsule, fibrosis
Trans. Vis. Sci. Tech.. 2023; 12(2):31. https://doi.org/10.1167/tvst.12.2.31

Includes: Supplemental Content

Artificial Intelligence February 2023

Machine Learning Analysis of Postkeratoplasty Endothelial Cell Images for the Prediction of Future Graft Rejection

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Naomi Joseph; Beth Ann Benetz; Prathyush Chirra; Harry Menegay; Silke Oellerich; Lamis Baydoun; Gerrit R. J. Melles; Jonathan H. Lass; David L. Wilson
TAGS: diagnostic imaging, endothelial cells, machine learning, rejection (psychology), transplant rejection, eye, descemet membrane endothelial keratoplasty, datasets
Trans. Vis. Sci. Tech.. 2023; 12(2):22. https://doi.org/10.1167/tvst.12.2.22

Includes: Supplemental Content

Cornea January 2023

ETS1–HMGA2 Axis Promotes Human Limbal Epithelial Stem Cell Proliferation

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Bofeng Wang; Huizhen Guo; Dongmei Liu; Siqi Wu; Jiafeng Liu; Xihong Lan; Huaxing Huang; Fengjiao An; Jin Zhu; Jianping Ji; Li Wang; Hong Ouyang; Mingsen Li
TAGS: epithelial stem cells, genes, hmga2 protein, chromatin immunoprecipitation sequencing, epithelium, protein overexpression, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):12. https://doi.org/10.1167/iovs.64.1.12

Includes: Supplemental Content

Cornea & External Disease December 2022

Ex Vivo Evaluation of a Pressure-Sensitive Device to Aid Big Bubble Intrastromal Dissection in Deep Anterior Lamellar Keratoplasty

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Alfonso Iovieno; Luigi Fontana; Marco Coassin; Dario Bovio; Caterina Salito
TAGS: keratoplasty, tissue dissection
Trans. Vis. Sci. Tech.. 2022; 11(12):17. https://doi.org/10.1167/tvst.11.12.17

Includes: Multimedia, Supplemental Content

Cornea December 2022

Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures

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Wei Zhang; Alfrun Schönberg; Fiona Bassett; Karina Hadrian; Deniz Hos; Martina Becker; Felix Bock; Claus Cursiefen
TAGS: cornea, keratoplasty, wounds and injuries, mice, angiogenesis, lymph, alkalies, burns, sutures, inflammatory cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):18. https://doi.org/10.1167/iovs.63.13.18

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit November 2022

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

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John P. M. Wood; Glyn Chidlow; Luke A. Halliday; Robert J. Casson; Dinesh Selva; Michelle Sun
TAGS: body tissue, langer-giedion syndrome, engineering
Trans. Vis. Sci. Tech.. 2022; 11(11):10. https://doi.org/10.1167/tvst.11.11.10

Includes: Supplemental Content

Retina October 2022

A Long-Term Safety and Efficacy Report on Intravitreal Delivery of Adipose Stem Cells and Secretome on Visual Deficits After Traumatic Brain Injury

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Pratheepa Kumari Rasiah; Kumar Abhiram Jha; Jordy Gentry; Nobel A. Del Mar; Tanisha Townsend; Kwame E. Torgbe; Anton Reiner; Rajashekhar Gangaraju
TAGS: ambulatory surgery center, blast injuries, eye, intravitreal injections, mice, safety, secretome, stem cells, traumatic brain injuries, saline solutions
Trans. Vis. Sci. Tech.. 2022; 11(10):1. https://doi.org/10.1167/tvst.11.10.1

Includes: Supplemental Content

Cornea & External Disease September 2022

Carbon Nanostructures for Ocular Tissue Reinforcement

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Joaquin Silvestre; Shihao Chen; Zheng Zheng; Alfredo Vega; Tong Chen; Francisco Rodríguez-Reinoso; Pin Zhu; Shuang Zeng; Yaru Zheng; Fangjun Bao; Yong Liu; Jorge L. Alió
TAGS: carbon, cornea, nanostructures, body tissue, ophthalmology, reinforcement, nanotechnology
Trans. Vis. Sci. Tech.. 2022; 11(9):1. https://doi.org/10.1167/tvst.11.9.1

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2022

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

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Jiale Diao; Xinxin Chen; Pei Mou; Xiaoye Ma; Ruili Wei
TAGS: berberine, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, inflammation, western blotting, proteins, enzyme-linked immunosorbent assay, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):6. https://doi.org/10.1167/iovs.63.10.6

Includes: Supplemental Content

Cornea July 2022

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction

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Kirill E. Zhurenkov; Elga I. Alexander-Sinkler; Ilya O. Gavrilyik; Natalia M. Yartseva; Svetlana A. Aleksandrova; Tatiana V. Mashel; Julia I. Khorolskaya; Miralda I. Blinova; Alexei N. Kulikov; Sergei V. Churashov; Valery F. Chernysh; Natalia A. Mikhailova
TAGS: cornea, epithelium, lip, mucous membrane, oryctolagus cuniculus, patient isolation, reconstructive surgical procedures, social isolation, stem cells, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):16. https://doi.org/10.1167/iovs.63.8.16

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2022

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy

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Bo Yi Kim; Soo Hyun Choi; Ji-Young Kim; JaeSang Ko; Jong In Yook; Hyun Sil Kim; Eun Jig Lee; Don O. Kikkawa; Jin Sook Yoon
TAGS: body tissue, bone morphogenetic proteins, fibroblasts, molecule, pathogenesis, proteins, tumor necrosis factors, western blotting, cytokine, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):7. https://doi.org/10.1167/iovs.63.6.7

Includes: Supplemental Content

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Isolation and Characterization of Human Conjunctival Mesenchymal Stromal Cells and Their Extracellular Vesicles

Discovery of CTSK + Periosteal Stem Cells Mediating Bone Repair in Orbital Reconstruction

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy

Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization

Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

Letter to the Editor: Characterization of Choriocapillaris and Choroidal Abnormalities in Alport Syndrome

Deep Learning Using Preoperative AS-OCT Predicts Graft Detachment in DMEK

Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty

ALK5 Inhibition of Subconjunctival Scarring From Glaucoma Surgery: Effects of SB-431542 Compared to Mitomycin C in Human Tenon's Capsule Fibroblasts

Machine Learning Analysis of Postkeratoplasty Endothelial Cell Images for the Prediction of Future Graft Rejection

ETS1–HMGA2 Axis Promotes Human Limbal Epithelial Stem Cell Proliferation

Ex Vivo Evaluation of a Pressure-Sensitive Device to Aid Big Bubble Intrastromal Dissection in Deep Anterior Lamellar Keratoplasty

Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

A Long-Term Safety and Efficacy Report on Intravitreal Delivery of Adipose Stem Cells and Secretome on Visual Deficits After Traumatic Brain Injury

Carbon Nanostructures for Ocular Tissue Reinforcement

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy

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