Nanotechnology and Regenerative Medicine

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Cornea March 2024

Substrate Stiffness Modulates Stemness and Differentiation of Rabbit Corneal Endothelium Through the Paxillin–YAP Pathway

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Shuting Liu; Hua Chen; Huatao Xie; Xin Liu; Mingchang Zhang
TAGS: chronic exertional compartment syndrome, cornea, corneal endothelium, oryctolagus cuniculus, scirrhous adenocarcinoma
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):15. https://doi.org/10.1167/iovs.65.3.15

Includes: Supplemental Content

Retina February 2024

Chorioretinal Atrophy Growth After Voretigene Neparvovec Retinotopically Is Connected to Retinal Functional Rescue

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Krunoslav Stingl; Melanie Kempf; Ronja Jung; Katarina Stingl
TAGS: atrophy, chorioretinal atrophy, gene therapy, rod photoreceptors, voretigene neparvovec
Trans. Vis. Sci. Tech.. 2024; 13(2):13. https://doi.org/10.1167/tvst.13.2.13

Cornea January 2024

Effector T Cells Promote Fibrosis in Corneal Transplantation Failure

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Shudan Wang; Sharad K. Mittal; Seokjoo Lee; Antonio Esquivel Herrera; Mark Krauthammer; Elsayed Elbasiony; Tomas Blanco; Hamid Alemi; Hayate Nakagawa; Sunil K. Chauhan; Reza Dana; Thomas H. Dohlman
TAGS: fibrosis, keratoplasty, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):40. https://doi.org/10.1167/iovs.65.1.40

Includes: Supplemental Content

Anatomy and Pathology/Oncology December 2023

The Use of rAAV2-RB1–Mediated Gene Therapy in Retinoblastoma

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Hanhan Shi; Xiaoyu He; Zhi Yang; Qili Liao; Jing Ruan; Shengfang Ge; Peiwei Chai; Renbing Jia; Jiayan Fan; Xuyang Wen; Xianqun Fan
TAGS: gene therapy, retinoblastoma, neoplasms, mice, intravitreal injections, western blotting, spatial vectors
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):31. https://doi.org/10.1167/iovs.64.15.31

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract December 2023

Poster Session II: Intravitreal gene therapy in primate reaches extrafoveal cones

Briyana Bembry - Colegrove; Michelle Giarmarco; Rachel Barborek; Jessica Rowlan; James Kuchenbecker; Dragos Rezeanu; Jay Neitz; Maureen Neitz
TAGS: gene therapy, posters, primates, retinal cone
Journal of Vision. 2023; 23(15):66. https://doi.org/10.1167/jov.23.15.66

Optica Fall Vision Meeting Abstract December 2023

Invited Session II: Retinal remodeling and regeneration: Insights into retinal cell replacement: Optimising photoreceptor and RPE transplantation

Karen Tessmer; Sylvia Jane Gasparini; Juliane Hammer; Trishla Adhikari; Klara Schmidtke; Sebastian Knöbel; Marius Ader
TAGS: photoreceptors, transplantation
Journal of Vision. 2023; 23(15):10. https://doi.org/10.1167/jov.23.15.10

Optica Fall Vision Meeting Abstract December 2023

Invited Session II: Retinal remodeling and regeneration: Stimulation of functional neural regeneration in adult mouse retina

Thomas Reh
TAGS: adult, mice, nerve regeneration, retina
Journal of Vision. 2023; 23(15):8. https://doi.org/10.1167/jov.23.15.8

Optica Fall Vision Meeting Abstract December 2023

Invited Session II: Retinal remodeling and regeneration: Developing autologous iPSC-RPE therapy for the treatment of AMD patients

Ruchi Sharma; Kapil Bharti
TAGS: induced pluripotent stem cells
Journal of Vision. 2023; 23(15):9. https://doi.org/10.1167/jov.23.15.9

Optica Fall Vision Meeting Abstract December 2023

Contributed Session III: AAV-mediated gene therapy for PDE6C achromatopsia: Progress and challenges

Ala Moshiri; Tawfik Issa; Jeffrey Rogers; Rui Chen; Sara Thomasy; Tim Stout
TAGS: achromatopsia, gene therapy
Journal of Vision. 2023; 23(15):81. https://doi.org/10.1167/jov.23.15.81

Retina November 2023

A Microfluidic Platform for the Time-Resolved Interrogation of Polarized Retinal Pigment Epithelial Cells

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Eric C. Spivey; Jinggang Yin; Edward Chaum; John P. Wikswo
TAGS: retinal pigment cell, vascular endothelial growth factor a, fluid flow, bodily secretions, hypoxia
Trans. Vis. Sci. Tech.. 2023; 12(11):28. https://doi.org/10.1167/tvst.12.11.28

Includes: Supplemental Content

Immunology and Microbiology November 2023

NF-κB c-Rel Is a Potential Therapeutic Target for Acute Corneal Transplant Rejection

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Qian Zheng; Ruiling Liu; Bian Jiang; Jijun Sun; Ting Wang; Qingguo Ruan
TAGS: keratoplasty, mice, rejection (psychology), symptom aggravating factors
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):16. https://doi.org/10.1167/iovs.64.14.16

Includes: Supplemental Content

Retinal Cell Biology November 2023

Medium Depth Influences O 2 Availability and Metabolism in Human RPE Cultures

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Daniel T. Hass; Qitao Zhang; Gillian A. Autterson; Richard A. Bryan; James B. Hurley; Jason M. L. Miller
TAGS: glucose, hypoxia, lactates, metabolism, metabolites, volume, cell culture techniques, induced pluripotent stem cells, lipids, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):4. https://doi.org/10.1167/iovs.64.14.4

Includes: Supplemental Content

Cornea October 2023

Characterization of the Limbal Epithelial Stem Cell Niche

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Isabel Y. Moreno; Arian Parsaie; Tarsis F. Gesteira; Vivien J. Coulson-Thomas
TAGS: cornea, epithelial stem cells, genes, immunohistochemistry, proteins, western blotting
Invest. Ophthalmol. Vis. Sci.. 2023; 64(13):48. https://doi.org/10.1167/iovs.64.13.48

Includes: Supplemental Content

Cornea October 2023

Keratocyte-Derived Myofibroblasts: Functional Differences With Their Fibroblast Precursors

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Ana C. Acosta; Hadi Joud; Mei Sun; Marcel Y. Avila; Curtis E. Margo; Edgar M. Espana
TAGS: collagen, fibroblasts, keratocytes, myofibroblasts, cornea, cicatrix
Invest. Ophthalmol. Vis. Sci.. 2023; 64(13):9. https://doi.org/10.1167/iovs.64.13.9

Cornea September 2023

Extracellular Vesicle MicroRNAs From Corneal Stromal Stem Cell Enhance Stemness of Limbal Epithelial Stem Cells by Targeting the Notch Pathway

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Leying Wang; Xizhan Xu; Qiankun Chen; Yuan Wei; Zhenyu Wei; Zi-Bing Jin; Qingfeng Liang
TAGS: cornea, epithelial stem cells, extracellular vesicles, mesenchymal stem cells, micrornas, phenotype
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):42. https://doi.org/10.1167/iovs.64.12.42

Includes: Supplemental Content

Cornea September 2023

Isolation and Characterization of Human Conjunctival Mesenchymal Stromal Cells and Their Extracellular Vesicles

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Laura García-Posadas; Ismael Romero-Castillo; Kieran Brennan; Margaret M. Mc Gee; Alfonso Blanco-Fernández; Yolanda Diebold
TAGS: antioxidants, conjunctiva, extracellular vesicles, mesenchymal stem cells, patient isolation, social isolation, body tissue, flow cytometry, conjunctival epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):38. https://doi.org/10.1167/iovs.64.12.38

Includes: Supplemental Content

Physiology and Pharmacology August 2023

Discovery of CTSK + Periosteal Stem Cells Mediating Bone Repair in Orbital Reconstruction

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Zeyang Liu; Jin Liu; Jipeng Li; Yinwei Li; Jing Sun; Yuan Deng; Huifang Zhou
TAGS: orbital reconstruction, osteoplasty, periosteum, stem cells, zygomatic bones, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):30. https://doi.org/10.1167/iovs.64.11.30

Biochemistry and Molecular Biology August 2023

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy

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Hyeong Ju Byeon; Min Kyung Chae; JaeSang Ko; Eun Jig Lee; Don O. Kikkawa; Sun Young Jang; Jin Sook Yoon
TAGS: complement factor d, fibroblasts, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):13. https://doi.org/10.1167/iovs.64.11.13

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2023

Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization

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Jilu Jaffet; Aparna Mohanty; Induvahi Veernala; Swati Singh; Mohammad Javed Ali; Sayan Basu; Geeta K. Vemuganti; Vivek Singh
TAGS: lacrimal gland, langer-giedion syndrome, mesenchymal stem cells, patient isolation, social isolation, body tissue, gene expression, flow cytometry, fluorescent antibody technique, 5'-nucleotidase
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):12. https://doi.org/10.1167/iovs.64.10.12

Includes: Supplemental Content

Review June 2023

Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions

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Selina Drag; Farokh Dotiwala; Arun K. Upadhyay
TAGS: gene therapy
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):39. https://doi.org/10.1167/iovs.64.7.39

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Substrate Stiffness Modulates Stemness and Differentiation of Rabbit Corneal Endothelium Through the Paxillin–YAP Pathway

Chorioretinal Atrophy Growth After Voretigene Neparvovec Retinotopically Is Connected to Retinal Functional Rescue

Effector T Cells Promote Fibrosis in Corneal Transplantation Failure

The Use of rAAV2-RB1–Mediated Gene Therapy in Retinoblastoma

Poster Session II: Intravitreal gene therapy in primate reaches extrafoveal cones

Invited Session II: Retinal remodeling and regeneration: Insights into retinal cell replacement: Optimising photoreceptor and RPE transplantation

Invited Session II: Retinal remodeling and regeneration: Stimulation of functional neural regeneration in adult mouse retina

Invited Session II: Retinal remodeling and regeneration: Developing autologous iPSC-RPE therapy for the treatment of AMD patients

Contributed Session III: AAV-mediated gene therapy for PDE6C achromatopsia: Progress and challenges

A Microfluidic Platform for the Time-Resolved Interrogation of Polarized Retinal Pigment Epithelial Cells

NF-κB c-Rel Is a Potential Therapeutic Target for Acute Corneal Transplant Rejection

Medium Depth Influences O 2 Availability and Metabolism in Human RPE Cultures

Characterization of the Limbal Epithelial Stem Cell Niche

Keratocyte-Derived Myofibroblasts: Functional Differences With Their Fibroblast Precursors

Extracellular Vesicle MicroRNAs From Corneal Stromal Stem Cell Enhance Stemness of Limbal Epithelial Stem Cells by Targeting the Notch Pathway

Isolation and Characterization of Human Conjunctival Mesenchymal Stromal Cells and Their Extracellular Vesicles

Discovery of CTSK + Periosteal Stem Cells Mediating Bone Repair in Orbital Reconstruction

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy

Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization

Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions

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