Retina

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Retina September 2022

SZN-413, a FZD4 Agonist, as a Potential Novel Therapeutic for the Treatment of Diabetic Retinopathy

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Huy Nguyen; Hui Chen; Meghah Vuppalapaty; Elizabeth Whisler; Kelsey Ronarda Logas; Parthasarathy Sampathkumar; Russell Byron Fletcher; Asmiti Sura; Nicholas Suen; Suhani Gupta; Tom Lopez; Jay Ye; Shengjiang Tu; Menaka Bolaki; Wen-Chen Yeh; Yang Li; Sung-Jin Lee
TAGS: agonists, diabetic retinopathy, retinal diseases, vascular endothelial growth factor a, proteins, endothelial cells, retina, mice, signal transduction, ischemia
Trans. Vis. Sci. Tech.. 2022; 11(9):19. doi: https://doi.org/10.1167/tvst.11.9.19

Includes: Supplemental Content

Retina September 2022

Topographical Analysis of the Choriocapillaris Reperfusion After Loading Anti-VEGF Therapy in Neovascular AMD

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Pasquale Viggiano; Maria Oliva Grassi; Mariagrazia Pignataro; Giacomo Boscia; Enrico Borrelli; Teresa Molfetta; Federica Evangelista; Giovanni Alessio; Francesco Boscia
TAGS: anti-vascular endothelial growth factor therapy, chief complaint, exudative age-related macular degeneration, physiologic reperfusion, reperfusion therapy, macular neovascularization
Trans. Vis. Sci. Tech.. 2022; 11(9):18. doi: https://doi.org/10.1167/tvst.11.9.18

Glaucoma September 2022

Biological Correlations and Confounders for Quantification of Retinal Ganglion Cells by Optical Coherence Tomography Based on Studies of Outbred Mice

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Adam Hedberg-Buenz; Kacie J. Meyer; Carly J. van der Heide; Wenxiang Deng; Kyungmoo Lee; Dana A. Soukup; Monica Kettelson; Danielle Pellack; Hannah Mercer; Kai Wang; Mona K. Garvin; Michael D. Abramoff; Michael G. Anderson
TAGS: axon, diagnostic imaging, mice, optic nerve, optical coherence tomography, retina, retinal ganglion cells, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2022; 11(9):17. doi: https://doi.org/10.1167/tvst.11.9.17

Includes: Supplemental Content

Retinal Cell Biology September 2022

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

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Shereen H. Chew; Cassandra Martinez; Kathleen R. Chirco; Sangeetha Kandoi; Deepak A. Lamba
TAGS: organoids, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):12. doi: https://doi.org/10.1167/iovs.63.10.12

Includes: Supplemental Content

Retina September 2022

Radial and Tangential Retinal Magnifications as Functions of Visual Field Angle Across Spherical, Oblate, and Prolate Retinal Profiles

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Gareth D. Hastings; Martin S. Banks; Austin Roorda
TAGS: magnification, retina, eye
Trans. Vis. Sci. Tech.. 2022; 11(9):10. doi: https://doi.org/10.1167/tvst.11.9.10

Includes: Multimedia, Supplemental Content

Retina September 2022

The Impact of Image Processing Algorithms on Optical Coherence Tomography Angiography Metrics and Study Conclusions in Diabetic Retinopathy

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Isaac G. Freedman; Emily Li; Lucy Hui; Ron A. Adelman; Kristen Nwanyanwu; Jay C. Wang
TAGS: angiogram, diabetic retinopathy, optical coherence tomography
Trans. Vis. Sci. Tech.. 2022; 11(9):7. doi: https://doi.org/10.1167/tvst.11.9.7

Includes: Supplemental Content

Retina September 2022

Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice

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Hung-Liang Pai; Sophie Meng-Tien Hsieh; Yu-Shan Su; Xin-Yuan Sue; Han-Hsin Chang; David Pei-Cheng Lin
TAGS: allopurinol, angiotensin ii, apoptosis, benzbromarone, gelatinase a, hyperuricemia, mice, pik3ca-related overgrowth spectrum, retinal injuries, urate measurement, serum
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):8. doi: https://doi.org/10.1167/iovs.63.10.8

Includes: Supplemental Content

Retina September 2022

UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair

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Ningda Xu; Yue Liu; Shanshan Nai; Yong Tao; Yuehe Ding; Lemei Jia; Qizhi Geng; Jie Li; Yujing Bai; Gong-Hong Wei; Meng-Qiu Dong; Linyi Luo; Mingwei Zhao; Xingzhi Xu; Xiao-Xin Li; Jing Li; Lvzhen Huang
TAGS: antibodies, blue light, chromatin, double strand break repair, immunoprecipitation, mice, proliferating cell nuclear antigen, proteins, electroretinography, plasmids
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):7. doi: https://doi.org/10.1167/iovs.63.10.7

Retina September 2022

Loss of Fas Receptor Function Preserves Photoreceptor Structure and Function in Two Mouse Models of Inherited Retinal Degeneration

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Jingyu Yao; Tiantian Wang; Lin Jia; Yaoyan Qiu; David N. Zacks
TAGS: cd95 antigens, mice, photoreceptors, retina, retinal degeneration, cytokine, inflammation, caspase-8
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):5. doi: https://doi.org/10.1167/iovs.63.10.5

Retina September 2022

Pupillary Responses Reveal Autonomic Regulation Impairments in Patients With Central Serous Chorioretinopathy

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Xiaoyin Zhou; Hisashi Fukuyama; Yoichi Okita; Hiroyuki Kanda; Yuki Yamamoto; Takashi Araki; Fumi Gomi
TAGS: autonomic nervous system, central serous chorioretinopathy, pupil light reflex, pupil reaction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):2. doi: https://doi.org/10.1167/iovs.63.10.2

Includes: Supplemental Content

Retina September 2022

Interobserver Agreement of Electrode to Retina Distance Measurements in a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

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Carla J. Abbott; Elizabeth K. Baglin; Maria Kolic; Myra B. McGuinness; Samuel A. Titchener; Kiera A. Young; Jonathan Yeoh; Chi D. Luu; Lauren N. Ayton; Matthew A. Petoe; Penelope J. Allen
TAGS: retina, visual prosthesis, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2022; 11(9):4. doi: https://doi.org/10.1167/tvst.11.9.4

Retina August 2022

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

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Yida Jiang; Li-Juan Duan; Jingbo Pi; Yun-Zheng Le; Guo-Hua Fong
TAGS: body tissue, heme, mice, oxidative stress, oxygenases, painful bladder syndrome, personal integrity, retinal pigment cell, retinal pigment epithelium, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):30. doi: https://doi.org/10.1167/iovs.63.9.30

Includes: Supplemental Content

Retinal Cell Biology August 2022

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice

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Lili Lian; Yifan Zhai; Xuejiao Wan; Linxin Chen; Zuimeng Liu; Ruona Liu; Shijia Li; Jiajia Zhou; Yu Chen; Ling Hou; Huirong Li
TAGS: mice, photoreceptors, retina, retinal cone, sodium, tissue degeneration, wounds and injuries, iodates, albinism, mice, inbred c57bl
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):29. doi: https://doi.org/10.1167/iovs.63.9.29

Includes: Supplemental Content

Retina August 2022

Quantification and Predictors of OCT-Based Macular Curvature and Dome-Shaped Configuration: Results From the UK Biobank

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Philipp L. Müller; Yuka Kihara; Abraham Olvera-Barrios; Alasdair N. Warwick; Catherine Egan; Katie M. Williams; Aaron Y. Lee; Adnan Tufail; for the UK Biobank Eyes and Vision Consortium
TAGS: biobanks, cohort studies, eye, myopia, refractive errors, diagnostic imaging, ethnic group, hyperopia, smoking in pregnancy, congenital abnormality
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):28. doi: https://doi.org/10.1167/iovs.63.9.28

Includes: Supplemental Content

Retina August 2022

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease

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Young Ho Kim; Ariunaa Togloom; Jaeryung Oh
TAGS: abnormal color, choroid, eye, face, pigmentation, uveomeningoencephalitic syndrome
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):27. doi: https://doi.org/10.1167/iovs.63.9.27

Retina August 2022

Retinal Transcriptome and Cellular Landscape in Relation to the Progression of Diabetic Retinopathy

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Jiang-Hui Wang; Raymond C. B. Wong; Guei-Sheung Liu
TAGS: diabetic retinopathy, genes, gender, cyclin d1, gene expression, donors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):26. doi: https://doi.org/10.1167/iovs.63.9.26

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics August 2022

Spatial and Temporal Integration Abnormalities in X-Linked Retinoschisis

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J. Jason McAnany; Jason C. Park; Gerald A. Fishman; Robert A. Hyde
TAGS: fovea centralis, luminance, visual fields, x-linked retinoschisis
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):22. doi: https://doi.org/10.1167/iovs.63.9.22

Includes: Supplemental Content

Retina August 2022

Histologic Cell Shape Descriptors for the Retinal Pigment Epithelium in Age-Related Macular Degeneration: A Comparison to Unaffected Eyes

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Leon von der Emde; Marc Vaisband; Jan Hasenauer; Leonie Bourauel; Katharina Bermond; Marlene Saßmannshausen; Rainer Heintzmann; Frank G. Holz; Christine A. Curcio; Kenneth R. Sloan; Thomas Ach
TAGS: age-related macular degeneration, aging, eye, language morphology, morphology, retinal pigment cell, retinal pigment epithelium, shape, donors
Trans. Vis. Sci. Tech.. 2022; 11(8):19. doi: https://doi.org/10.1167/tvst.11.8.19

Anatomy and Pathology/Oncology August 2022

UBE2T/STAT3 Signaling Promotes the Proliferation and Tumorigenesis in Retinoblastoma

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Nuo Xu; Yi Cui; Hong Shi; Guodong Guo; Fengyuan Sun; Tianming Jian; Huiying Rao
TAGS: retinoblastoma, stat3 protein, tumorigenesis, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):20. doi: https://doi.org/10.1167/iovs.63.9.20

Includes: Supplemental Content

Retina August 2022

Effects of Sleep Deprivation, Non-Dominant Hand Employment, Caffeine and Alcohol Intake During Surgical Performance: Lessons Learned From the Retina Eyesi Virtual Reality Surgical Simulator

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Feisal A. Adatia; Gerardo González-Saldivar; David R. Chow
TAGS: alcohol drinking, caffeine, ethanol, hand, hand surgery, retina, simulators, sleep deprivation, surgical procedures, operative, virtual reality
Trans. Vis. Sci. Tech.. 2022; 11(8):16. doi: https://doi.org/10.1167/tvst.11.8.16

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SZN-413, a FZD4 Agonist, as a Potential Novel Therapeutic for the Treatment of Diabetic Retinopathy

Topographical Analysis of the Choriocapillaris Reperfusion After Loading Anti-VEGF Therapy in Neovascular AMD

Biological Correlations and Confounders for Quantification of Retinal Ganglion Cells by Optical Coherence Tomography Based on Studies of Outbred Mice

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

Radial and Tangential Retinal Magnifications as Functions of Visual Field Angle Across Spherical, Oblate, and Prolate Retinal Profiles

The Impact of Image Processing Algorithms on Optical Coherence Tomography Angiography Metrics and Study Conclusions in Diabetic Retinopathy

Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice

UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair

Loss of Fas Receptor Function Preserves Photoreceptor Structure and Function in Two Mouse Models of Inherited Retinal Degeneration

Pupillary Responses Reveal Autonomic Regulation Impairments in Patients With Central Serous Chorioretinopathy

Interobserver Agreement of Electrode to Retina Distance Measurements in a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice

Quantification and Predictors of OCT-Based Macular Curvature and Dome-Shaped Configuration: Results From the UK Biobank

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease

Retinal Transcriptome and Cellular Landscape in Relation to the Progression of Diabetic Retinopathy

Spatial and Temporal Integration Abnormalities in X-Linked Retinoschisis

Histologic Cell Shape Descriptors for the Retinal Pigment Epithelium in Age-Related Macular Degeneration: A Comparison to Unaffected Eyes

UBE2T/STAT3 Signaling Promotes the Proliferation and Tumorigenesis in Retinoblastoma

Effects of Sleep Deprivation, Non-Dominant Hand Employment, Caffeine and Alcohol Intake During Surgical Performance: Lessons Learned From the Retina Eyesi Virtual Reality Surgical Simulator

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