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Clinical and Epidemiologic Research June 2017

Optic Nerve Tilt, Crescent, Ovality, and Torsion in a Multi-Ethnic Cohort of Young Adults With and Without Myopia

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Wendy L. Marsh-Tootle; Elise Harb; Wei Hou; Qinghua Zhang; Heather A. Anderson; Katherine Weise; Thomas T. Norton; Jane Gwiazda; Leslie Hyman; for the Correction of Myopia Evaluation Trial (COMET) Study Group
TAGS: cohort studies, myopia, optic disk, musculoskeletal torsion, function, eye, optic nerve, young adult, torsion
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3158-3171. doi: 10.1167/iovs.16-20860

Includes: Supplemental Content

Articles June 2017

Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment

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Ellen Townes-Anderson; Jianfeng Wang; Éva Halász; Ilene Sugino; Amy Pitler; Ian Whitehead; Marco Zarbin
TAGS: retinal detachment, rod photoreceptors, synapses, eye
Trans. Vis. Sci. Tech.. 2017; 6(3):22. doi: 10.1167/tvst.6.3.22

Retina June 2017

Reliability and Agreement Between Metrics of Cone Spacing in Adaptive Optics Images of the Human Retinal Photoreceptor Mosaic

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Daniela Giannini; Giuseppe Lombardo; Letizia Mariotti; Nicholas Devaney; Sebastiano Serrao; Marco Lombardo
TAGS: retinal cone, optics, photoreceptors, retinal diseases, mosaicism, reliability, chief complaint
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3127-3137. doi: 10.1167/iovs.16-20890

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2017

The Urokinase Receptor-Derived Peptide UPARANT Recovers Dysfunctional Electroretinogram and Blood–Retinal Barrier Leakage in a Rat Model of Diabetes

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Maurizio Cammalleri; Filippo Locri; Stefania Marsili; Massimo Dal Monte; Claudio Pisano; Angelo Mancinelli; Liliana Lista; Dario Rusciano; Mario De Rosa; Vincenzo Pavone; Paola Bagnoli
TAGS: diabetes mellitus, urokinase, blood-retinal barrier, electroretinography, peptides, eye, rats, retina
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3138-3148. doi: 10.1167/iovs.17-21593

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2017

Pattern Recognition Analysis of Age-Related Retinal Ganglion Cell Signatures in the Human Eye

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Nayuta Yoshioka; Barbara Zangerl; Lisa Nivison-Smith; Sieu K. Khuu; Bryan W. Jones; Rebecca L. Pfeiffer; Robert E. Marc; Michael Kalloniatis
TAGS: cohort studies, pattern recognition, regression analysis, retinal ganglion cells, eye, linear regression
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3086-3099. doi: 10.1167/iovs.17-21450

Includes: Supplemental Content

Retinal Cell Biology June 2017

Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model

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Chih-Cheng Chien; Chi-Jung Huang; Lu-Tai Tien; Yu-Che Cheng; Chia-Ying Ke; Yih-Jing Lee
TAGS: apoptosis, electroretinography, animal model, photoreceptors, retinal degeneration, retina, exposure to light
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3107-3117. doi: 10.1167/iovs.16-21007

Includes: Supplemental Content

Special Issue June 2017

Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration

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Maximilian Pfau; Lukas Goerdt; Steffen Schmitz-Valckenberg; Matthias M. Mauschitz; Divyansh K. Mishra; Frank G. Holz; Moritz Lindner; Monika Fleckenstein
TAGS: atrophy, diagnostic imaging, age-related macular degeneration, global assessment of functioning, autofluorescence, blue light, green light
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO121-BIO130. doi: 10.1167/iovs.17-21764

Anatomy and Pathology/Oncology June 2017

Looking for the Most Suitable Orthotopic Retinoblastoma Mouse Model in Order to Characterize the Tumoral Development

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Stéphanie Lemaitre; Florent Poyer; Sergio Marco; Paul Fréneaux; François Doz; Isabelle Aerts; Laurence Desjardins; Nathalie Cassoux; Carole D. Thomas
TAGS: injection of therapeutic agent, retinal detachment, retinoblastoma, transplantation, heterologous, diagnostic imaging, eye, mice, neoplasms, tumor cells, engraftment, tumor growth, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3055-3064. doi: 10.1167/iovs.17-21760

Retinal Cell Biology June 2017

Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration

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Riccardo Natoli; Nilisha Fernando; Haihan Jiao; Tanja Racic; Michele Madigan; Nigel L. Barnett; Joshua A. Chu-Tan; Krisztina Valter; Jan Provis; Matt Rutar
TAGS: atrophy, complement system proteins, macrophage, retinal degeneration, mice, retina, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2977-2990. doi: 10.1167/iovs.17-21672

Includes: Supplemental Content

Glaucoma June 2017

Parapapillary Deep-Layer Microvasculature Dropout in Glaucoma: Topographic Association With Glaucomatous Damage

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Eun Ji Lee; Seung Hyen Lee; Jeong-Ah Kim; Tae-Woo Kim
TAGS: glaucoma, open-angle glaucoma, eye, retinal nerve fiber layer, microvascular network
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3004-3010. doi: 10.1167/iovs.17-21918

Article June 2017

Chromatic interocular-switch rivalry

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Jens H. Christiansen; Anthony D. D'Antona; Steven K. Shevell
TAGS: color, perception, eye, luminance
Journal of Vision. 2017; 17(5):9. doi: 10.1167/17.5.9

Visual Neuroscience June 2017

Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3

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Robert M. Duvoisin; Tammie L. Haley; Gaoying Ren; Iwona Strycharska-Orczyk; James P. Bonaparte; Catherine W. Morgans
TAGS: autoantibodies, epitopes, antibodies, retinopathy, melanoma associated, serum
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2732-2738. doi: 10.1167/iovs.17-21443

Visual Neuroscience June 2017

Compromised Integrity of Central Visual Pathways in Patients With Macular Degeneration

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Maka Malania; Julia Konrad; Herbert Jägle; John S. Werner; Mark W. Greenlee
TAGS: atrophy, visual pathways, macular degeneration, optic tract, retinal nerve fiber layer, personal integrity, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2939-2947. doi: 10.1167/iovs.16-21191

Retina June 2017

Specific Alleles of CLN7 / MFSD8 , a Protein That Localizes to Photoreceptor Synaptic Terminals, Cause a Spectrum of Nonsyndromic Retinal Dystrophy

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Kamron N. Khan; Mohammed E. El-Asrag; Cristy A. Ku; Graham E. Holder; Martin McKibbin; Gavin Arno; James A. Poulter; Keren Carss; Tejaswi Bommireddy; Saghar Bagheri; Benjamin Bakall; Hendrik P. Scholl; F. Lucy Raymond; Carmel Toomes; Chris F. Inglehearn; Mark E. Pennesi; Anthony T. Moore; Michel Michaelides; Andrew R. Webster; Manir Ali; for NIHR BioResource-Rare Diseases and UK Inherited Retinal Disease Consortium
TAGS: alleles, presynaptic terminals, mutation, fluorescent antibody technique, photoreceptors, retinal diseases, retinitis pigmentosa, proteins, retina, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2906-2914. doi: 10.1167/iovs.16-20608

Includes: Supplemental Content

Retinal Cell Biology June 2017

High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy

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Thomas Tien; Joyce Zhang; Tetsuya Muto; Dongjoon Kim; Vijay P. Sarthy; Sayon Roy
TAGS: mitochondria, glucose, diabetic retinopathy, cytochrome c, mitomycin, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2915-2921. doi: 10.1167/iovs.16-21355

Articles June 2017

Natural History of Rod-Mediated Dark Adaptation over 2 Years in Intermediate Age-Related Macular Degeneration

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Cynthia Owsley; Mark E. Clark; Gerald McGwin, Jr
TAGS: dark adaptation, natural history, rod photoreceptors, eye, age-related macular degeneration
Trans. Vis. Sci. Tech.. 2017; 6(3):15. doi: 10.1167/tvst.6.3.15

Retina June 2017

Repeatability and Reproducibility of Retinal Blood Flow Measurement Using a Doppler Optical Coherence Tomography Flowmeter in Healthy Subjects

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Tomofumi Tani; Young-Seok Song; Takafumi Yoshioka; Tsuneaki Omae; Akihiro Ishibazawa; Masahiro Akiba; Akitoshi Yoshida
TAGS: vascular flow, arteriole, flowmeters, optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2891-2898. doi: 10.1167/iovs.16-21389

Visual Neuroscience June 2017

Corneal Potential Maps Measured With Multi-Electrode Electroretinography in Rat Eyes With Experimental Lesions

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Zahra Derafshi; Brian E. Kunzer; Emily M. Mugler; Nataliya Rokhmanova; Dong-Wook Park; Hadi Tajalli; Krithi Shetty; Zhenqiang Ma; Justin C. Williams; John R. Hetling
TAGS: cornea, eye, retina, maps, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2863-2873. doi: 10.1167/iovs.16-20726

Retina June 2017

Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging

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Mariana López-Luppo; Joana Catita; David Ramos; Marc Navarro; Ana Carretero; Luísa Mendes-Jorge; Pura Muñoz-Cánoves; Alfonso Rodriguez-Baeza; Victor Nacher; Jesus Ruberte
TAGS: aging, retinal vessels, retina, retinal microaneurysm, elderly, microaneurysm, cell aging
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2832-2842. doi: 10.1167/iovs.16-20312

Physiology and Pharmacology June 2017

Subconjunctival Delivery of p75 NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy

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Alba Galan; Pablo F. Barcelona; Hinyu Nedev; Marinko V. Sarunic; Yifan Jian; H. Uri Saragovi
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, injection of therapeutic agent, mice, retina, antagonists, subconjunctival route
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2852-2862. doi: 10.1167/iovs.16-20988

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Optic Nerve Tilt, Crescent, Ovality, and Torsion in a Multi-Ethnic Cohort of Young Adults With and Without Myopia

Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment

Reliability and Agreement Between Metrics of Cone Spacing in Adaptive Optics Images of the Human Retinal Photoreceptor Mosaic

The Urokinase Receptor-Derived Peptide UPARANT Recovers Dysfunctional Electroretinogram and Blood–Retinal Barrier Leakage in a Rat Model of Diabetes

Pattern Recognition Analysis of Age-Related Retinal Ganglion Cell Signatures in the Human Eye

Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model

Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Looking for the Most Suitable Orthotopic Retinoblastoma Mouse Model in Order to Characterize the Tumoral Development

Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration

Parapapillary Deep-Layer Microvasculature Dropout in Glaucoma: Topographic Association With Glaucomatous Damage

Chromatic interocular-switch rivalry

Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3

Compromised Integrity of Central Visual Pathways in Patients With Macular Degeneration

Specific Alleles of CLN7 / MFSD8 , a Protein That Localizes to Photoreceptor Synaptic Terminals, Cause a Spectrum of Nonsyndromic Retinal Dystrophy

High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy

Natural History of Rod-Mediated Dark Adaptation over 2 Years in Intermediate Age-Related Macular Degeneration

Repeatability and Reproducibility of Retinal Blood Flow Measurement Using a Doppler Optical Coherence Tomography Flowmeter in Healthy Subjects

Corneal Potential Maps Measured With Multi-Electrode Electroretinography in Rat Eyes With Experimental Lesions

Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging

Subconjunctival Delivery of p75 NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy

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