Biochemistry and Molecular Biology

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Retina March 2025

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

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Rajya L. Gurung; Charvi Nangia; Tengda Cai; Liesel M. FitzGerald; Bennet J. McComish; Ebony Liu; Georgia Kaidonis; Bronwyn Ridge; Alex W. Hewitt; Brendan Vote; Nitin Verma; Jamie E. Craig; Colin N. A. Palmer; Kathryn P. Burdon; Weihua Meng
TAGS: cohort studies, diabetes mellitus, genetics, genome-wide association study, macular disorders, meta-analysis, single nucleotide polymorphism, genotype determination, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):55. https://doi.org/10.1167/iovs.66.3.55

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

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Hua Zhang; Shuning Lan; Disuo Ren; Xiaoyan Chen; Yong Lin; Qiongjie Cao; Weiwei Xu; Jiao Wang; Peter Sol Reinach; Dongsheng Yan; Guangying Luo
TAGS: cornea, dna methylation, epigenetics, epithelium, genes, rna, tumorigenesis, wound healing, neoplasms, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):54. https://doi.org/10.1167/iovs.66.3.54

Includes: Supplemental Content

Cornea March 2025

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

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Shiding Li; Hao Sun; Fei Fang; Siyi Zhang; Junzhao Chen; Chunyi Shao; Yao Fu; Liangbo Chen
TAGS: body tissue, cell communication, cornea, epithelial stem cells, epithelium, fluorescent antibody technique, genes, rna, small cytoplasmic, transcriptomics, melanocytes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):52. https://doi.org/10.1167/iovs.66.3.52

Includes: Supplemental Content

Glaucoma March 2025

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

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Yong-Feng Yang; Paul Holden; Ying Ying Sun; Jennifer A. Faralli; Donna M. Peters; Kate E. Keller
TAGS: fibrosis, genes, glaucoma, proteins, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):48. https://doi.org/10.1167/iovs.66.3.48

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

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Mingsu Shi; Rongmei Zhou; Weiai Shen; Yu Liang; Yihan Zhang; Lingyun Liu; Runyi Shao; Yanxi Fang; Chen Zhao; Lianqun Wu
TAGS: bodily secretions, genes, graves' ophthalmopathy, muscle of orbit, polymerase chain reaction, rna, sequence analysis, rna, sincalide, cell proliferation, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):46. https://doi.org/10.1167/iovs.66.3.46

Includes: Supplemental Content

Retinal Cell Biology March 2025

Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner

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Joseph Hanna; Yacine Touahri; Alissa Pak; Luke Ajay David; Edwin van Oosten; Rajiv Dixit; Laura M. Vecchio; Dhruv Nimesh Mehta; Ren Minamisono; Isabelle Aubert; Carol Schuurmans
TAGS: mechanistic target of rapamycin complex 1, photoreceptors, pten gene, retina, tissue degeneration, rod photoreceptors, precipitating factors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):45. https://doi.org/10.1167/iovs.66.3.45

Includes: Supplemental Content

Retinal Cell Biology March 2025

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

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Xiaodi Zhou; Xiaoxiao Xu; Qiong Wang; Yanting Lai; Linyan Zhang; Yunfeng Lin; Xiaoyan Ding; Limei Sun
TAGS: endothelial cells, hypoxia, notch1 gene, retinal neovascularization, rna, small interfering, signal transduction, proteins, neovascularization, pathologic, ischemia, fluorescence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):39. https://doi.org/10.1167/iovs.66.3.39

Anatomy and Pathology/Oncology March 2025

Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera

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Hongshuang Lu; Yijin Wu; Jianping Xiong; Nan Zhou; Masahiro Yamanari; Michiaki Okamoto; Keigo Sugisawa; Hiroyuki Takahashi; Changyu Chen; Yining Wang; Ziye Wang; Kyoko Ohno-Matsui
TAGS: collagen fiber, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):35. https://doi.org/10.1167/iovs.66.3.35

Includes: Multimedia, Supplemental Content

Visual Neuroscience March 2025

Modulation of All- Trans Retinoic Acid by Light and Dopamine in the Murine Eye

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Sarah Talwar; Reece Mazade; Melissa Bentley-Ford; Jianshi Yu; Nageswara Pilli; Maureen A. Kane; C. Ross Ethier; Machelle T. Pardue
TAGS: eye, mice, tretinoin, retinoids, lighting, dopamine, light exposure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):37. https://doi.org/10.1167/iovs.66.3.37

Multidisciplinary Ophthalmic Imaging March 2025

Three-Dimensional β-Amyloid Burden Correlation Between the Eye and Brain in Alzheimer's Disease Mice Using Light-Sheet Fluorescence Microscopy

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Hye Joo Son; Seonok Kim; Seog-Young Kim; Jin Hwa Jung; Suk Hyun Lee; Soo-Jong Kim; Chanwoo Kim; Alice Hahn
TAGS: alzheimer's disease, amyloid, brain, eye, mice, microscopy, fluorescence, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):34. https://doi.org/10.1167/iovs.66.3.34

Includes: Multimedia, Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Glaucoma March 2025

Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization

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Dong Eun Kim; Do Young Park; Jong Chul Han
TAGS: aqueous humor, corneal neovascularization, mass or substance concentration per volume, oryctolagus cuniculus, vascular endothelial growth factor a, viscosity, choroidal neovascularization, copy number polymorphism, eye, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(3):9. https://doi.org/10.1167/tvst.14.3.9

Cornea March 2025

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

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David Diaz; Joseph W. Sassani; Ian S. Zagon; Patricia J. McLaughlin
TAGS: cornea, diabetes mellitus, dry eye syndromes, naltrexone, opioid receptor, rats, corneal epithelium, trigeminal ganglion
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):24. https://doi.org/10.1167/iovs.66.3.24

Includes: Supplemental Content

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2025

Magnetic Resonance Dacryocystography for Precise Diagnosis of Lacrimal and Perilacrimal Lesions

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Xuejun Guo; Min Gao; Yulong Qi; Qiao Shi; Qiqiang Li; Mingmei Li; Hongbing Li
TAGS: dacryocystography, lacrimal canaliculus, lacrimal sac, magnetic resonance imaging, vibration, constriction, pathologic, eye, nasolacrimal duct, surgical pathology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):17. https://doi.org/10.1167/iovs.66.3.17

Clinical and Epidemiologic Research March 2025

Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

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Alexis O'Neil; Roshan A. Welikala; Sarah Barman; Christopher G. Owen; Alicja R. Rudnicka; Mohan Rakesh; Marie-Hélène Roy-Gagnon; David Maberley; Ellen E. Freeman
TAGS: aging, longitudinal studies, retinal vessels, obesity, diabetes mellitus, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):13. https://doi.org/10.1167/iovs.66.3.13

Genetics March 2025

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses

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Pirro G. Hysi; Christopher J. Hammond
TAGS: cell lines, genes, genome-wide association study, libraries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):11. https://doi.org/10.1167/iovs.66.3.11

Includes: Supplemental Content

Refractive Intervention March 2025

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

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Hongwei Qin; Xin Yang; Rui He; Yaowen Song; Junchao Wei; Xiaona Liu; Chenyan Wang; Ce Wu; Jie Hou; Zhipeng Gao; Lingfeng Chen; Xiaona Li; Weiyi Chen
TAGS: cornea, oryctolagus cuniculus, biomechanics, stress, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):3. https://doi.org/10.1167/tvst.14.3.3

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

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Pingbo Ouyang; Jia Qi; Boding Tong; Yunping Li; Jiamin Cao; Lujue Wang; Tongxin Niu; Xin Qi
TAGS: butyrates, fibroblasts, gastrointestinal microbiome, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):5. https://doi.org/10.1167/iovs.66.3.5

Includes: Supplemental Content

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Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera

Modulation of All- Trans Retinoic Acid by Light and Dopamine in the Murine Eye

Three-Dimensional β-Amyloid Burden Correlation Between the Eye and Brain in Alzheimer's Disease Mice Using Light-Sheet Fluorescence Microscopy

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

Magnetic Resonance Dacryocystography for Precise Diagnosis of Lacrimal and Perilacrimal Lesions

Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

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