Clinical and Epidemiologic Research

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Clinical and Epidemiologic Research May 2025

Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight

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Charles Bélanger Nzakimuena; Marissé Masís Solano; Rémy Marcotte-Collard; Mark Richard Lesk; Santiago Costantino
TAGS: choroid, space flight, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):17. https://doi.org/10.1167/iovs.66.5.17

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2025

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

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Maria K. Walker; David A. Berntsen; Matt L. Robich; Rachel L. Fenton; Anita Ticak; Justina R. Assaad; Hope M. Queener; Stephanie J. Chiu; Sina Farsiu; Donald O. Mutti; Lisa A. Jones-Jordan; Jeffrey J. Walline; for the BLINK Study Group
TAGS: child, choroid, contact lenses, lens (device), lens, crystalline, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):5. https://doi.org/10.1167/iovs.66.5.5

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Absolute Risks and Decision Tools for Communicating the Risks of Visual Impairment From Myopia-Related Diseases

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Emma Dow; Stephanie Kearney; Mhairi Day
TAGS: myopia, open-angle glaucoma, rhegmatogenous retinal detachment, visual impairment, decision support systems
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):82. https://doi.org/10.1167/iovs.66.4.82

Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

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Yu Peng; Yuzhou Zhang; Ka Wai Kam; Gavin Wong; Mary Ho; Simon Sezto; Sunny Au; Xiujuan Zhang; Mandy P. H. Ng; Patrick Ip; Alvin Young; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Jason C. Yam
TAGS: health, macular disorders, uk biobank, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):63. https://doi.org/10.1167/iovs.66.4.63

Includes: Supplemental Content

Retina April 2025

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

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Serhat Ermiş; Ece Özal; Emrullah Şimşek; Özlem Taştan; Murat Karapapak
TAGS: biometry, magnification, prospective studies, fovea centralis, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):57. https://doi.org/10.1167/iovs.66.4.57

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Contributed Talks III: The Berkeley Widefield Model Eye

Austin Roorda; Pavan Tiruveedhula; Gareth Dudley Hastings
TAGS: eye
Journal of Vision. 2025; 25(5):56. https://doi.org/10.1167/jov.25.5.56

Retina March 2025

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

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Rajya L. Gurung; Charvi Nangia; Tengda Cai; Liesel M. FitzGerald; Bennet J. McComish; Ebony Liu; Georgia Kaidonis; Bronwyn Ridge; Alex W. Hewitt; Brendan Vote; Nitin Verma; Jamie E. Craig; Colin N. A. Palmer; Kathryn P. Burdon; Weihua Meng
TAGS: cohort studies, diabetes mellitus, genetics, genome-wide association study, macular disorders, meta-analysis, single nucleotide polymorphism, genotype determination, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):55. https://doi.org/10.1167/iovs.66.3.55

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

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Yue Li; Jiaqi Tang; Gaojing Jing; Yueyue Li; Rui Ma; Xin Kang; Liyuan Rong; Wenlu Liu; Lan Yao; Xiaohui Lv; Aijun Deng; Wei Wu; Xinji Yang
TAGS: connective tissue, cytokine, histopathology tests, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):33. https://doi.org/10.1167/iovs.66.3.33

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

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Joseph Magagnoli; Tammy Cummings; James W. Hardin; S. Scott Sutton; Jayakrishna Ambati
TAGS: age-related macular degeneration, bisphosphonates, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):32. https://doi.org/10.1167/iovs.66.3.32

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

The Epidemiology of Eye Cancer, Eyelid Cancer, and Ophthalmic Lymphoma in a Chinese Population in Hong Kong: A Population-Based Registry Study 2005–2018

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Allie Lee; Dennis T. W. Law; Alex H. S. Kan; Flores F. P. Cruz; Vishal Jhanji; Hunter K. L. Yuen; Michael Y. Ni
TAGS: chinese (other dialects), eye, eye cancer, eyelid neoplasms, hong kong, lymphoma, chinese people, epidemiology, incidence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):15. https://doi.org/10.1167/iovs.66.3.15

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

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Alexis O'Neil; Roshan A. Welikala; Sarah Barman; Christopher G. Owen; Alicja R. Rudnicka; Mohan Rakesh; Marie-Hélène Roy-Gagnon; David Maberley; Ellen E. Freeman
TAGS: aging, longitudinal studies, retinal vessels, obesity, diabetes mellitus, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):13. https://doi.org/10.1167/iovs.66.3.13

Cornea February 2025

Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

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Ramaraj Kannan; Rohit Shetty; Trailokyanath Panigrahi; Siew Kwan Koh; Pooja Khamar; Vrushali Deshpande; Rudy M. M. A. Nuijts; Marlies Gijs; Krishnatej Nishtala; Lei Zhou; Arkasubhra Ghosh
TAGS: proteins, cohort studies, keratoconus, proteomics, signal transduction, metabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):60. https://doi.org/10.1167/iovs.66.2.60

Includes: Supplemental Content

Retina February 2025

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

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Gilad Allon; Siying Lin; Anthony G. Robson; Gavin Arno; Magella M. Neveu; Pirro G. Hysi; Michel Michaelides; Andrew R. Webster; Omar A. Mahroo
TAGS: cohort studies, diagnostic imaging, genetics, retinal diseases, visual acuity, electrophysiology, family, eye, vision
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):50. https://doi.org/10.1167/iovs.66.2.50

Clinical and Epidemiologic Research February 2025

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

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Qiuxuan Du; Ying Zhang; Yusen Huang
TAGS: cataract, cataract, childhood, chinese (other dialects), chinese people, eye, growth rate, intraocular lens implantation procedure, multifocal intraocular lenses, refraction, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):33. https://doi.org/10.1167/iovs.66.2.33

Retina February 2025

Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study

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Ziqi Tang; Dawei Yang; Truong X. Nguyen; Shuyi Zhang; Danqi Fang; Victor T. T. Chan; Clement C. Tham; Elliott H. Sohn; Ken K. Tsang; Cherie Y. K. Wong; Vivian W. K. Hui; Amy H. Y. Yu; Julia T. W. Lam; Carmen K. M. Chan; Timothy Y. Y. Lai; Simon K. H. Szeto; Carol Y. Cheung
TAGS: cohort studies, diabetes mellitus, diabetic retinopathy, dorsal raphe nucleus, nerve degeneration, eye, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):32. https://doi.org/10.1167/iovs.66.2.32

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Clinical and Epidemiologic Research February 2025

Anthropometric Measures and Fuchs' Endothelial Corneal Dystrophy: The Women's Health Initiative Observational Study

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Yihua Yue; Sangita P. Patel; Jing Nie; Chris A. Andrews; Jean Wactawski-Wende; Aladdin H. Shadyab; Robert Wallace; Amy E. Millen
TAGS: anthropometric measures, body mass index procedure, endothelium, hereditary corneal dystrophy, women's health initiative, obesity, significance, body weight
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):26. https://doi.org/10.1167/iovs.66.2.26

Includes: Supplemental Content

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Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

Absolute Risks and Decision Tools for Communicating the Risks of Visual Impairment From Myopia-Related Diseases

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

Contributed Talks III: The Berkeley Widefield Model Eye

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

The Epidemiology of Eye Cancer, Eyelid Cancer, and Ophthalmic Lymphoma in a Chinese Population in Hong Kong: A Population-Based Registry Study 2005–2018

Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

Anthropometric Measures and Fuchs' Endothelial Corneal Dystrophy: The Women's Health Initiative Observational Study

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