Cornea

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Cornea January 2025

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

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Yankai Wei; Mei Sun; Xinyu Zhang; Chengyuan Zhang; Chao Yang; Hong Nian; Bei Du; Ruihua Wei
TAGS: dry eye syndromes, mice, sjogren's syndrome, stat3 protein, th17 cells, langer-giedion syndrome, dendritic cells, t-lymphocytes, mice, inbred nod, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):35. https://doi.org/10.1167/iovs.66.1.35

Includes: Supplemental Content

Immunology and Microbiology January 2025

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

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Jiahui Yang; Jing Zhong; Zhenyuan Fu; Dalian He; Jing Zhang; Jin Yuan
TAGS: cornea, fungal keratitis, infections, macrophages, marenostrin, mice, phagocytosis, proteins, mycoses, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):33. https://doi.org/10.1167/iovs.66.1.33

Includes: Supplemental Content

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Cornea January 2025

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

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Nishant R. Sinha; Alexandria C. Hofmann; Laila A. Suleiman; Maxwell T. Jeffrey; William C. Jeffrey; Rajnish Kumar; Ratnakar Tripathi; Rajiv R. Mohan
TAGS: corneal injuries, ferroptosis, mitogen-activated protein kinase p38, mustard gas, signal transduction, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):23. https://doi.org/10.1167/iovs.66.1.23

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2025

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

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Qiongjie Cao; Wenji Xu; Xiaoyan Chen; Guangying Luo; Peter S. Reinach; Dongsheng Yan
TAGS: arginine, cornea, epigenetics, epithelium, methylation, wound healing, regulation, mice, western blotting, histones
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):22. https://doi.org/10.1167/iovs.66.1.22

Includes: Supplemental Content

Cornea January 2025

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

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Chun-Hsiang Chang; I-Chen Peng; Yi-Hsun Huang
TAGS: alkalies, burns, cornea, macrophage activation, thrombomodulin, wound healing
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):21. https://doi.org/10.1167/iovs.66.1.21

Cornea January 2025

miRNA Expression Profile in Primary Limbal Epithelial Cells of Aniridia Patients

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Mahsa Nastaranpour; Shweta Suiwal; Tanja Stachon; Fabian N. Fries; Maryam Amini; Berthold Seitz; Eckart Meese; Nicole Ludwig; Nóra Szentmáry
TAGS: aniridia, epithelial cells, micrornas, candidate disease gene
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):20. https://doi.org/10.1167/iovs.66.1.20

Includes: Supplemental Content

Cornea January 2025

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

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Yan Shen; Jiajia Wang; Yiqin Dai; Xichen Wan; Jing Zhang; Qihua Le
TAGS: corneal epithelium, epithelial stem cells, signal pathway, signal transduction pathways, wounds and injuries, proteins, mice, wound healing, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):8. https://doi.org/10.1167/iovs.66.1.8

Includes: Supplemental Content

Glaucoma December 2024

Clinical Validation of M-TONX: A Novel Combo Rebound Tonometer and Pachymeter

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Naveed Nilforushan; Mozafar Yousefi; Ankica Babic; Arash Gharehbaghi
TAGS: cardiac ct, intraocular pressure, tonometers, cornea
Trans. Vis. Sci. Tech.. 2024; 13(12):34. https://doi.org/10.1167/tvst.13.12.34

Cornea December 2024

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

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Zhiwei Zha; Decheng Xiao; Zihao Liu; Fangli Peng; Xunjie Shang; Zhenzhen Sun; Yang Liu; Wei Chen
TAGS: cyclophosphamide, doxorubicin, prednisone, and vincristine, dry eye syndromes, nlr family, pyrin domain-containing 3 protein, signal pathway, signal transduction pathways, stress, mice, endoplasmic reticulum, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):34. https://doi.org/10.1167/iovs.65.14.34

Includes: Supplemental Content

Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Cornea & External Disease December 2024

Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy

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Ioannis N. Petropoulos; Kareem Essam Aly; Shaikha Al-Thani; Georgios Ponirakis; Hoda Gad; Adnan Khan; Beatriz Canibano; Dirk Deleu; Naveed Akhtar; Gayane Melikyan; Boulenouar Mesraoua; Maria Siddiqi; Jon Perkins; Novsheen Mir; Reny Francis; Abdul Salam; Ahmed El-Sotouhy; Surjith Vattoth; Ahmed Own; Saadat Kamran; Rayaz A. Malik
TAGS: cornea, epilepsy, microscopy, confocal, multiple sclerosis, nerve degeneration
Trans. Vis. Sci. Tech.. 2024; 13(12):22. https://doi.org/10.1167/tvst.13.12.22

Cornea & External Disease December 2024

The Effect of Terpinen-4-ol on Human Corneal Epithelium

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Joo-Hee Park; Choul Yong Park
TAGS: cell survival, cornea, corneal epithelium, epithelium, toxic effect, corneal epithelial cells, mass or substance concentration per volume, cell count, eyelid scrub, immunocytochemistry
Trans. Vis. Sci. Tech.. 2024; 13(12):18. https://doi.org/10.1167/tvst.13.12.18

Includes: Supplemental Content

Cornea & External Disease December 2024

Eye-Rubbing Detection Tool Using Artificial Intelligence on a Smartwatch in the Management of Keratoconus

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Ines Drira; Ayoub Louja; Layth Sliman; Vincent Soler; Maha Noor; Abdellah Jamali; Pierre Fournie
TAGS: artificial intelligence, eye, keratoconus, smartwatches, training, machine learning
Trans. Vis. Sci. Tech.. 2024; 13(12):16. https://doi.org/10.1167/tvst.13.12.16

Cornea & External Disease December 2024

Quantifying the Corneal Nerve Whorl Pattern

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Maryse Lapierre-Landry; Eric Y. Lu; Matthew T. McPheeters; Made Airanthi K. Widjaja-Adhi; David L. Wilson; Rony R. Sayegh; Patricia R. Taylor; Marcin Golczak; Michael W. Jenkins
TAGS: cornea, datasets, neurons, mice, diabetes mellitus
Trans. Vis. Sci. Tech.. 2024; 13(12):11. https://doi.org/10.1167/tvst.13.12.11

Includes: Supplemental Content

Cornea December 2024

Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease

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Xin Zuo; Hao Zeng; Xue Yang; Dalian He; Bowen Wang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, loeys-dietz syndrome, proteins, stress, western blotting, autophagy, lipid peroxidation, lysosomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):12. https://doi.org/10.1167/iovs.65.14.12

Includes: Supplemental Content

Cornea December 2024

A Sex-Dependent Cannabinoid CB1 Receptor Role in Circadian Tearing of the Mouse

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Natalia Murataeva; Kyle Yust; Sam Mattox; Wenwen Du; Alex Straiker
TAGS: cannabinoids, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):10. https://doi.org/10.1167/iovs.65.14.10

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

Clinical Trials November 2024

A Comparative and Prospective Study of Corneal Consumption and Corneal Biomechanics After SMILE and FS-LASIK Performed on the Contralateral Eyes With High Myopic Astigmatism

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Xiangtao Hou; Pei Chen; Na Yu; Yiqi Luo; Han Wei; Jing Zhuang; Keming Yu
TAGS: astigmatism, biomechanics, cardiac ct, cornea, eye, keratomileusis, laser in situ, laser surgery, prospective studies, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2024; 13(11):29. https://doi.org/10.1167/tvst.13.11.29

Cornea & External Disease November 2024

Investigating the Tolerance of Corneal Endothelial Cells to Surgical Fluid Pressure Using Intact Porcine Eyes

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Alex J. McMullen; Zaynab A. Dantsoho; Scott Chamness; John Brunelle; Jaime Martiz; Yousuf M. Khalifa; Mark R. Buckley
TAGS: cornea, eye, scirrhous adenocarcinoma, suidae, surgical procedures, operative, endothelial cells
Trans. Vis. Sci. Tech.. 2024; 13(11):27. https://doi.org/10.1167/tvst.13.11.27

Includes: Supplemental Content

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S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

miRNA Expression Profile in Primary Limbal Epithelial Cells of Aniridia Patients

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

Clinical Validation of M-TONX: A Novel Combo Rebound Tonometer and Pachymeter

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy

The Effect of Terpinen-4-ol on Human Corneal Epithelium

Eye-Rubbing Detection Tool Using Artificial Intelligence on a Smartwatch in the Management of Keratoconus

Quantifying the Corneal Nerve Whorl Pattern

Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease

A Sex-Dependent Cannabinoid CB1 Receptor Role in Circadian Tearing of the Mouse

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

A Comparative and Prospective Study of Corneal Consumption and Corneal Biomechanics After SMILE and FS-LASIK Performed on the Contralateral Eyes With High Myopic Astigmatism

Investigating the Tolerance of Corneal Endothelial Cells to Surgical Fluid Pressure Using Intact Porcine Eyes

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