External Eye Disease

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Cornea December 2024

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

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Zhiwei Zha; Decheng Xiao; Zihao Liu; Fangli Peng; Xunjie Shang; Zhenzhen Sun; Yang Liu; Wei Chen
TAGS: cyclophosphamide, doxorubicin, prednisone, and vincristine, dry eye syndromes, nlr family, pyrin domain-containing 3 protein, signal pathway, signal transduction pathways, stress, mice, endoplasmic reticulum, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):34. https://doi.org/10.1167/iovs.65.14.34

Includes: Supplemental Content

Cornea December 2024

Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease

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Xin Zuo; Hao Zeng; Xue Yang; Dalian He; Bowen Wang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, loeys-dietz syndrome, proteins, stress, western blotting, autophagy, lipid peroxidation, lysosomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):12. https://doi.org/10.1167/iovs.65.14.12

Includes: Supplemental Content

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

Cornea & External Disease November 2024

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

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Hao-Yu Wang; Dan Shen; Meng-Ying Qi; Chen Qiao; Lan Ke; Mingwu Wang; Qing-Yan Zeng
TAGS: blepharitis, eyelid, mites, ocular surfaces, eyelid margin, follow-up
Trans. Vis. Sci. Tech.. 2024; 13(11):22. https://doi.org/10.1167/tvst.13.11.22

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Cornea November 2024

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

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Xiaowei Yang; Xingwu Zhong; Haotian Lin; Andrew J.W. Huang; Lixing W. Reneker
TAGS: atrophy, epithelium, fgfr2 gene, meibomian gland dysfunction, mice, tamoxifen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):36. https://doi.org/10.1167/iovs.65.13.36

Includes: Supplemental Content

Anatomy and Pathology/Oncology November 2024

Treatment of Conjunctival Melanoma Cell Lines With a Light-Activated Virus-Like Drug Conjugate Induces Immunogenic Cell Death

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Sen Ma; Ruben V. Huis In't Veld; Elisabet de los Pinos; Ferry A. Ossendorp; Martine J. Jager
TAGS: cell lines, cytotoxicity, drug conjugates, immunogenic cell death, malignant melanoma of conjunctiva, viruses, tumor cells, hsp90 heat-shock proteins, polymyositis, prednimustine
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):3. https://doi.org/10.1167/iovs.65.13.3

Includes: Supplemental Content

Clinical and Epidemiologic Research October 2024

Predictors of Discordance Between Dry Eye Symptoms and Signs: Insights From the Sjögren's International Collaborative Clinical Alliance

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Fanxiu Xiong; Benjamin F. Arnold; Thomas M. Lietman; John A. Gonzales
TAGS: dry eye syndromes, signs and symptoms, sjogren's syndrome, ocular signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):3. https://doi.org/10.1167/iovs.65.12.3

Includes: Supplemental Content

Cornea & External Disease October 2024

Key Clinical and Histopathological Features of a Pterygium-Like Induced Lesion in a Rabbit Model

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Carlos A. Rodríguez-Barrientos; Gloria Regina Ayala-Villegas; Jorge E. Valdez-García; Judith Zavala
TAGS: histopathology tests, oryctolagus cuniculus, pterygium
Trans. Vis. Sci. Tech.. 2024; 13(10):1. https://doi.org/10.1167/tvst.13.10.1

Cornea October 2024

Mesenchymal Stem Cells-Derived Exosomal miR-223-3p Alleviates Ocular Surface Damage and Inflammation by Downregulating Fbxw7 in Dry Eye Models

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Guifang Wang; Yujie Zhu; Yuzhen Liu; Mulin Yang; Li Zeng
TAGS: bacterial artificial chromosomes, blood alcohol concentration, bronchioloalveolar carcinoma, dry eye syndromes, f-box-wd repeat-containing protein 7, fbxw7 gene, inflammation, mice, ocular surfaces, cornea
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):1. https://doi.org/10.1167/iovs.65.12.1

Includes: Supplemental Content

Cornea & External Disease September 2024

The Effect of Amniotic Membrane Transplantation or Conjunctival Autografts on the Tear Mucins MUC5A and MUC2 After Pterygium Resection: A Six-Month Follow-Up

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Ángel Nava-Castañeda; Lilia Garnica-Hayashi; Noé Santiago-Rea; Edric González-Mondragón; Beatriz Buentello-Volante; Fátima Sofía Magaña-Guerrero; Yonathan Garfias
TAGS: conjunctiva, mucins, pterygium, transplantation, transplantation, autologous, follow-up, amnion, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2024; 13(9):10. https://doi.org/10.1167/tvst.13.9.10

Cornea & External Disease August 2024

Multimodal Approach in Dry Eye Disease Combining In Vivo Confocal Microscopy and HLA-DR Expression

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Benjamin Blautain; Ghislaine Rabut; Bénédicte Dupas; Luisa Riancho; Hong Liang; Jade Luzu; Antoine Labbé; Jean-Sébastien Garrigue; Françoise Brignole-Baudouin; Christophe Baudouin; Karima Kessal
TAGS: dry eye syndromes, hla-dr antigens, microscopy, confocal, conjunctiva, signs and symptoms
Trans. Vis. Sci. Tech.. 2024; 13(8):39. https://doi.org/10.1167/tvst.13.8.39

Includes: Supplemental Content

Clinical and Epidemiologic Research August 2024

Recurrence in Eyelid Sebaceous Carcinoma: A Multicentric Study of 418 Patients

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Mingpeng Xu; Qian Chen; Yingxiu Luo; Peiwei Chai; Xiaoyu He; Hengye Huang; Jia Tan; Juan Ye; Chuandi Zhou
TAGS: recurrence, sebaceous adenocarcinoma of eyelid, nomogram
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):4. https://doi.org/10.1167/iovs.65.10.4

Includes: Supplemental Content

Clinical and Epidemiologic Research July 2024

Meibomian Gland Shortening Is Associated With Altered Meibum Composition

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Fatima Iqbal; Fiona Stapleton; Simin Masoudi; Eric B. Papas; Jacqueline Tan
TAGS: lipids, meibomian gland
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):49. https://doi.org/10.1167/iovs.65.8.49

Cornea July 2024

High Resolution Images of Human Meibum Spread on Saline

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P. Ewen King-Smith; Carolyn G. Begley; Richard J. Braun
TAGS: lipids, saline solutions, pixel
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):41. https://doi.org/10.1167/iovs.65.8.41

Immunology and Microbiology July 2024

Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjögren Disease–Like Lacrimal Gland Pathology

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Kaitlin K. Scholand; Jeremias Galletti; Wolfgang Haap; Tiago Santos-Ferreira; Christoph Ullmer; Cintia S. de Paiva
TAGS: autoimmunity, cathepsins, mice, sjogren's syndrome, pathology, t-lymphocytes, lacrimal gland, cornea
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):26. https://doi.org/10.1167/iovs.65.8.26

Includes: Supplemental Content

Cornea July 2024

Reticulated Retinoic Acid Synthesis is Implicated in the Pathogenesis of Dry Eye in Aqp5 Deficiency Mice

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Huanhuan Ge; Guohu Di; Bin Li; Wenshuo Han; Peirong Song; Shiheng Han; Dianqiang Wang; Peng Chen
TAGS: chronic exertional compartment syndrome, cornea, dry eye syndromes, mice, pathogenesis, polymerase chain reaction, sodium chloride, tretinoin, transcription factor, corneal epithelium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):25. https://doi.org/10.1167/iovs.65.8.25

Includes: Supplemental Content

Cornea & External Disease July 2024

Tear Fluid Progranulin as a Noninvasive Biomarker for the Monitoring of Corneal Innervation Changes in Patients With Type 2 Diabetes Mellitus

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Tianyi Zhou; Zhiwei Dou; Yuchen Cai; Dongqing Zhu; Yao Fu
TAGS: biological markers, cornea, diabetes mellitus, diabetes mellitus, type 2, grn gene, nerve supply, neurons, progranulins, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(7):9. https://doi.org/10.1167/tvst.13.7.9

Cornea June 2024

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

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Na Lin; Xin Chen; Haixia Liu; Ning Gao; Zhao Liu; Jin Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: dry eye syndromes, interleukin-13, mice, mucins, ocular surfaces, conjunctiva, balance, device, equilibrium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):39. https://doi.org/10.1167/iovs.65.6.39

Artificial Intelligence June 2024

Enhancing Meibography Image Analysis Through Artificial Intelligence–Driven Quantification and Standardization for Dry Eye Research

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Chun-Hsiao Yeh; Andrew D. Graham; Stella X. Yu; Meng C. Lin
TAGS: artificial intelligence, datasets, dreams, dry eye syndromes, eyelid, masks, tarsal plate, learning
Trans. Vis. Sci. Tech.. 2024; 13(6):16. https://doi.org/10.1167/tvst.13.6.16

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Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

Treatment of Conjunctival Melanoma Cell Lines With a Light-Activated Virus-Like Drug Conjugate Induces Immunogenic Cell Death

Predictors of Discordance Between Dry Eye Symptoms and Signs: Insights From the Sjögren's International Collaborative Clinical Alliance

Key Clinical and Histopathological Features of a Pterygium-Like Induced Lesion in a Rabbit Model

Mesenchymal Stem Cells-Derived Exosomal miR-223-3p Alleviates Ocular Surface Damage and Inflammation by Downregulating Fbxw7 in Dry Eye Models

The Effect of Amniotic Membrane Transplantation or Conjunctival Autografts on the Tear Mucins MUC5A and MUC2 After Pterygium Resection: A Six-Month Follow-Up

Multimodal Approach in Dry Eye Disease Combining In Vivo Confocal Microscopy and HLA-DR Expression

Recurrence in Eyelid Sebaceous Carcinoma: A Multicentric Study of 418 Patients

Meibomian Gland Shortening Is Associated With Altered Meibum Composition

High Resolution Images of Human Meibum Spread on Saline

Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjögren Disease–Like Lacrimal Gland Pathology

Reticulated Retinoic Acid Synthesis is Implicated in the Pathogenesis of Dry Eye in Aqp5 Deficiency Mice

Tear Fluid Progranulin as a Noninvasive Biomarker for the Monitoring of Corneal Innervation Changes in Patients With Type 2 Diabetes Mellitus

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

Enhancing Meibography Image Analysis Through Artificial Intelligence–Driven Quantification and Standardization for Dry Eye Research

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