Genetics

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Retina February 2025

High Levels of C5a Are Associated With Reduced Macular Sensitivity in Patients With Myeloproliferative Neoplasms

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Kathrine Gotfredsen; Andreas Abou-Taha; Charlotte Liisborg; Marie Krogh Nielsen; Morten Kranker Larsen; Vibe Skov; Lasse Kjær; Hans Karl Hasselbalch; Torben Lykke Sørensen
TAGS: drusen, myeloproliferative disease, inflammation, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):41. https://doi.org/10.1167/iovs.66.2.41

Includes: Supplemental Content

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Retina February 2025

Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish

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Xuebin Zhou; Jinfeng Cao; Jianan Xie; Wanqing Tong; Bo Jia; Jinling Fu
TAGS: photoreceptors, phototransduction, proteins, retina, zebrafish, protein transport, retinal degeneration, apoptosis, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):38. https://doi.org/10.1167/iovs.66.2.38

Includes: Supplemental Content

Cornea February 2025

Modeling Neuropathic Corneal Pain: Pulled Nerve Approach With Elevated Krt16 Gene Expression

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Mohd. Afzal Khan; Gehan Fatima; Acquah Emmanuel; Sang Seong Kim; Hyuk Sang Kwon; Kyung Chul Yoon; Young Ro Kim; Euiheon Chung
TAGS: cornea, gene expression, neurons, pain, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):35. https://doi.org/10.1167/iovs.66.2.35

Includes: Supplemental Content

Cornea February 2025

Contact Lens Wear Alters Transcriptional Responses to Pseudomonas aeruginosa in Both the Corneal Epithelium and the Bacteria

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Naren Gajenthra Kumar; Melinda R. Grosser; Stephanie Wan; Daniel Schator; Eugene Ahn; Eric Jedel; Vincent Nieto; David J. Evans; Suzanne M. J. Fleiszig
TAGS: bacteria, contact lenses, cornea, corneal epithelium, genes, lens (device), lens, crystalline, pseudomonas aeruginosa, transcription, genetic, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):31. https://doi.org/10.1167/iovs.66.2.31

Includes: Supplemental Content

Retina February 2025

Phenotypic Distinctions Between EYS - and USH2A -Associated Retinitis Pigmentosa in an Asian Population

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Ellis Y. H. Yeo; Taro Kominami; Tien-En Tan; Lathiksha Babu; Kevin G. S. Ong; Weilun Tan; Yasmin M. Bylstra; Kanika Jain; Rachael W. C. Tang; Saadia Z. Farooqui; Sylvia P. R. Kam; Choi-Mun Chan; Ranjana S. Mathur; Saumya S. Jamuar; Weng Khong Lim; Koji Nishiguchi; Beau J. Fenner
TAGS: asian, cohort studies, phenotype, retinitis pigmentosa, symptom onset, genotype
Trans. Vis. Sci. Tech.. 2025; 14(2):16. https://doi.org/10.1167/tvst.14.2.16

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Anthropometric Measures and Fuchs' Endothelial Corneal Dystrophy: The Women's Health Initiative Observational Study

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Yihua Yue; Sangita P. Patel; Jing Nie; Chris A. Andrews; Jean Wactawski-Wende; Aladdin H. Shadyab; Robert Wallace; Amy E. Millen
TAGS: anthropometric measures, body mass index procedure, endothelium, hereditary corneal dystrophy, women's health initiative, obesity, significance, body weight
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):26. https://doi.org/10.1167/iovs.66.2.26

Includes: Supplemental Content

Genetics February 2025

Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel

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Sarah van der Ende; Karen Bedard; Karin Wallace; Michael P. Mackley; Mathew Nightingale; Daniel Gaston; M. Jill Beis; Marissa A. Leblanc; Roxanne Gillett; Alex V. Levin; Ian H. Clark; Élise Héon; Rajeev H. Muni; Elias I. Traboulsi; Christopher J. Lyons; Christopher R. McMaster; Johane M. Robitaille; on behalf of The FEVR Consortium
TAGS: familial exudative vitreoretinopathies, genes, proband
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):23. https://doi.org/10.1167/iovs.66.2.23

Includes: Supplemental Content

Retinal Cell Biology February 2025

Regional Alterations in Müller Cell Protein Expression in Human and a Rat Model of Geographic Atrophy

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Poonam Naik; D. Scott McLeod; Imran A. Bhutto; Malia M. Edwards
TAGS: age-related macular degeneration, nonexudative, atrophic condition of skin, embryonic lethal mutation, eye, injections, proteins, retina, tissue membrane, glial fibrillary acidic protein, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):21. https://doi.org/10.1167/iovs.66.2.21

Includes: Supplemental Content

Physiology and Pharmacology February 2025

Aurora A Kinase Inhibition Is Synthetic Lethal With the Activation of MYCN in Retinoblastoma

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Qili Liao; Jie Yang; Hanhan Shi; Reyizha Mengjiang; Yongyun Li; Qianqian Zhang; Xuyang Wen; Shengfang Ge; Peiwei Chai; Xianqun Fan; Renbing Jia; Jiayan Fan
TAGS: mycn gene, phosphotransferases, retinoblastoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):20. https://doi.org/10.1167/iovs.66.2.20

Includes: Supplemental Content

Genetics February 2025

Characterizing the Genetic Basis for Inherited Retinal Disease: Lessons Learned From the Foundation Fighting Blindness Clinical Consortium's Gene Poll

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Kari Branham; Lassana Samarakoon; Isabelle Audo; Allison R. Ayala; Janet K. Cheetham; Stephen P. Daiger; Patty Dhooge; Jacque L. Duncan; Todd A. Durham; Abigail T. Fahim; Rachel M. Huckfeldt; Robert B. Hufnagel; Susanne Kohl; Ramiro S. Maldonado; Michele Melia; Michel Michaelides; Mark E. Pennesi; José-Alain Sahel; Juliana M. Ferraz Sallum; Mandeep S. Singh; Dror Sharon; Kimberly Stepien; Kaylie Jones; Christina Y. Weng; for the Foundation Fighting Blindness Clinical Consortium Investigator Group
TAGS: blindness, genes, genetics, retinal diseases, social survey
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):12. https://doi.org/10.1167/iovs.66.2.12

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Neuro-ophthalmology February 2025

Visual Tract Integrity Before and After Gene Therapy in Congenital Achromatopsia

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Hillel Abramovitch; Atira S. Bick; Nitzan Guy; Deena Elul; Ayelet Mckyton; Eyal Banin; Netta Levin
TAGS: achromatopsia, gene therapy, personal integrity, visual pathways, optic tract
Trans. Vis. Sci. Tech.. 2025; 14(2):9. https://doi.org/10.1167/tvst.14.2.9

Includes: Supplemental Content

Uveitis February 2025

Genetics of Circulating Inflammatory Proteins and Iridocyclitis: An Exploratory Mendelian Randomization Study

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Huan Liu; Fuzhen Li; Feiyan Wang; Ziqing Hu; Liping Du; Jing Wei
TAGS: cytokine, iridocyclitis, genetics, proteins, mendelian randomization analysis
Trans. Vis. Sci. Tech.. 2025; 14(2):6. https://doi.org/10.1167/tvst.14.2.6

Includes: Supplemental Content

Cornea February 2025

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

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Fang Han; Leyi Wang; Jiayin Wu; Lin Shen; Yangyang Li; Hui Guo; Jianqiao Li
TAGS: keratitis, leucine-rich repeat serine/threonine-protein kinase 2, lrrk2 gene, signal pathway, signal transduction pathways, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):13. https://doi.org/10.1167/iovs.66.2.13

Includes: Supplemental Content

Genetics February 2025

Genotype–Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes

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Fulya Yaylacıoğlu Tuncay; Melissa J. Reeves; Sairah Yousaf; Ehsan Ullah; Bin Guan; Kerry E. Goetz; Santa J. Tumminia; Robert B. Hufnagel
TAGS: cohort studies, familial exudative vitreoretinopathies, genes, genotype, phenotype, signal pathway, signal transduction pathways, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):9. https://doi.org/10.1167/iovs.66.2.9

Includes: Supplemental Content

Cornea February 2025

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

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Xiaojuan Hu; Jiayao Feng; Chengjie Pan; Zhenzhen Sun; Jiechen Liu; Shuang Xie; Decheng Xiao; Xiaoyin Ma; Qinxiang Zheng; Wei Chen
TAGS: dry eye syndromes, hmgb1 protein, lysosomes, borderline neoplasms, apoptosis, homeostasis, cell death, stress, date of last normal period, cytoplasm
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):5. https://doi.org/10.1167/iovs.66.2.5

Cornea February 2025

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

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Yanxiao Li; Zan Luo; Zihao Liu; Xinhao Zhu; Peter S. Reinach; Ling Li; Wei Chen
TAGS: dry eye syndromes, interleukin-23, conjunctiva, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):10. https://doi.org/10.1167/iovs.66.2.10

Includes: Supplemental Content

Public Health February 2025

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization

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Jianqi Chen; Xuhao Chen; Xu Cao; Xiaohua Zhuo; Yuwen Wen; Guitong Ye; Yuan Zhang; Jinan Zhan; Hongmei Tan; Yingting Zhu; Yehong Zhuo
TAGS: frailty, national health and nutrition examination survey, diabetic retinopathy, mendelian randomization analysis
Trans. Vis. Sci. Tech.. 2025; 14(2):2. https://doi.org/10.1167/tvst.14.2.2

Includes: Supplemental Content

Retina February 2025

Effect of the Sugar Present in the Culture Medium on the Preservation of Human RPE Cell Suspensions

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Shohei Kitahata; Hinako Ichikawa; Yuji Tanaka; Shin Tanaka; Tatsuya Inoue; Maiko Maruyama-Inoue; Kazuaki Kadonosono
TAGS: culture media, retinal pigment cell, sugars, fructose
Trans. Vis. Sci. Tech.. 2025; 14(2):1. https://doi.org/10.1167/tvst.14.2.1

Includes: Supplemental Content

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High Levels of C5a Are Associated With Reduced Macular Sensitivity in Patients With Myeloproliferative Neoplasms

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish

Modeling Neuropathic Corneal Pain: Pulled Nerve Approach With Elevated Krt16 Gene Expression

Contact Lens Wear Alters Transcriptional Responses to Pseudomonas aeruginosa in Both the Corneal Epithelium and the Bacteria

Phenotypic Distinctions Between EYS - and USH2A -Associated Retinitis Pigmentosa in an Asian Population

Anthropometric Measures and Fuchs' Endothelial Corneal Dystrophy: The Women's Health Initiative Observational Study

Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel

Regional Alterations in Müller Cell Protein Expression in Human and a Rat Model of Geographic Atrophy

Aurora A Kinase Inhibition Is Synthetic Lethal With the Activation of MYCN in Retinoblastoma

Characterizing the Genetic Basis for Inherited Retinal Disease: Lessons Learned From the Foundation Fighting Blindness Clinical Consortium's Gene Poll

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Visual Tract Integrity Before and After Gene Therapy in Congenital Achromatopsia

Genetics of Circulating Inflammatory Proteins and Iridocyclitis: An Exploratory Mendelian Randomization Study

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

Genotype–Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization

Effect of the Sugar Present in the Culture Medium on the Preservation of Human RPE Cell Suspensions

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