Glaucoma

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Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Glaucoma December 2024

A Pattern-Based OCT Metric for Glaucoma Detection

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Donald C. Hood; Sol La Bruna; Mary Durbin; Chris Lee; Anya Guzman; Tayna Gebhardt; Yujia Wang; Arin L. Stowman; Carlos Gustavo De Moraes; Michael Chaglasian; Emmanouil Tsamis
TAGS: eye, glaucoma, cohort studies
Trans. Vis. Sci. Tech.. 2024; 13(12):21. https://doi.org/10.1167/tvst.13.12.21

Includes: Supplemental Content

Artificial Intelligence December 2024

Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Sizes III and V in Glaucoma and NAION

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David Szanto; Michael Wall; Luke X. Chong; Brian Woods; Tobias Elze; Jui-Kai Wang; Mona Garvin; Randy Kardon; Mark J. Kupersmith
TAGS: glaucoma, nonarteritic anterior ischemic optic neuropathy, visual fields, antithymoglobulin, arterial tortuosity syndrome, periodic paralysis, potassium-sensitive cardiodysrhythmic type
Trans. Vis. Sci. Tech.. 2024; 13(12):15. https://doi.org/10.1167/tvst.13.12.15

Includes: Supplemental Content

Retina December 2024

Sterile Caliper Anterior Chamber Decompression Mitigates Intraocular Pressure Spikes in Intravitreal Injections

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Mahsaw Mansoor; Noor-Us-Sabah Ahmad; S. Bilal Ahmed; Samuel Tadros; James Folk; Michael D. Abramoff
TAGS: anterior chamber of eye, decompression, external, decompressive incision, intraocular pressure, intravitreal injections, injections, arm
Trans. Vis. Sci. Tech.. 2024; 13(12):13. https://doi.org/10.1167/tvst.13.12.13

Clinical Trials December 2024

A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry

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Viktoria Pai; Patrick Janku; Theresa Lindner; Ulrich Graf; Leopold Schmetterer; Gerhard Garhöfer; Doreen Schmidl
TAGS: lasers, oximetry, oxygen, oxygen extraction, oxygen saturation measurement, vascular flow, hypoxia, inspiration, respiration, hyperoxia
Trans. Vis. Sci. Tech.. 2024; 13(12):12. https://doi.org/10.1167/tvst.13.12.12

Genetics December 2024

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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Jiaying Li; Yun Chen; Wenbin Wang; Ye Zhang; Guangsong Su; Sean K. Wang; Yuanyuan Zhang; Yilong Yao; Shen Wu; Wange Lu; Kunlin Zhang; Chunyan Qiao; Shuning Li; Hengtong Li; Ching-Yu Cheng; Yuwen Liu; Ningli Wang
TAGS: angle closure glaucoma, iris, pathogenesis, enhancer of transcription, diagnostic imaging, chromatin, alleles, multiomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):18. https://doi.org/10.1167/iovs.65.14.18

Includes: Supplemental Content

Neuro-ophthalmology December 2024

Relating Standardized Automated Perimetry Performed With Stimulus Sizes III and V in Eyes With Field Loss Due to Glaucoma and NAION

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David Szanto; Michael Wall; Luke X. Chong; Mark J. Kupersmith
TAGS: eye, glaucoma, nonarteritic anterior ischemic optic neuropathy, perimetry
Trans. Vis. Sci. Tech.. 2024; 13(12):8. https://doi.org/10.1167/tvst.13.12.8

Includes: Supplemental Content

Glaucoma December 2024

The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients

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Cameron A. Czerpak; Michael Saheb Kashaf; Brandon K. Zimmerman; Rebecca Mirville; Nicolas C. Gasquet; Harry A. Quigley; Thao D. Nguyen
TAGS: eye, glaucoma, intraocular pressure, cribriform plate
Trans. Vis. Sci. Tech.. 2024; 13(12):7. https://doi.org/10.1167/tvst.13.12.7

Includes: Supplemental Content

Glaucoma December 2024

Sequence and Detectability of Changes in Macular Ganglion Cell Layer Thickness and Perfusion Density in Early Glaucoma

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Ryo Tomita; Corey A. Smith; Oksana M. Dyachok; Glen P. Sharpe; Paul E. Rafuse; Lesya M. Shuba; Marcelo T. Nicolela; Balwantray C. Chauhan
TAGS: glaucoma, perfusion, ganglia
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):8. https://doi.org/10.1167/iovs.65.14.8

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2024

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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Panagiotis Laspas; Alica Hartmann; Ida Scholz; Esther Maria Hoffmann; Anthony P. Khawaja; Karl Johannes Lackner; Thomas Münzel; Jasmin Ghaemi Kerahrodi; Irene Schmidtmann; Oliver Tüscher; Jörn Markus Schattenberg; Norbert Pfeiffer; Stavros Konstantinides; Philipp Sebastian Wild; Alexander Karl-Georg Schuster
TAGS: intraocular pressure, pharmaceutical preparations, health, beta-blockers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):4. https://doi.org/10.1167/iovs.65.14.4

Includes: Supplemental Content

Letters to the Editor December 2024

Author Response: Effect of Depth-Dependent Integrated Visual Field on Vision-Related Quality of Life in Glaucoma

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Andrew Turpin; Allison M. McKendrick
TAGS: glaucoma, quality of life, vision, visual fields
Trans. Vis. Sci. Tech.. 2024; 13(12):2. https://doi.org/10.1167/tvst.13.12.2

Retina November 2024

Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums

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Thanadet Chuangsuwanich; Tin A. Tun; Fabian A. Braeu; Rachel S. Chong; Xiaofei Wang; Ching-Lin Ho; Tin Aung; Michaël J. A. Girard; Quan V. Hoang
TAGS: glaucoma, intraocular pressure, macula lutea, sclera, nose, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):54. https://doi.org/10.1167/iovs.65.13.54

Includes: Supplemental Content

Glaucoma November 2024

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study

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Akiko Hanyuda; Yoshihiko Raita; Takahiro Ninomiya; Kazuki Hashimoto; Naoko Takada; Kota Sato; Jin Inoue; Seizo Koshiba; Gen Tamiya; Akira Narita; Masato Akiyama; Kazuko Omodaka; Satoru Tsuda; Yu Yokoyama; Noriko Himori; Yasuko Yamamoto; Takazumi Taniguchi; Kazuno Negishi; Toru Nakazawa
TAGS: glaucoma, metabolomics, open-angle glaucoma, multiomics, metabolites
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):44. https://doi.org/10.1167/iovs.65.13.44

Includes: Supplemental Content

Glaucoma November 2024

The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy

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Sarah E. Quillen; Elizabeth C. Kimball; Kelsey A. Ritter-Gordy; Liya Du; Zhuochen Yuan; Mary E. Pease; Salaheddine Madhoun; Thao D. Nguyen; Thomas V. Johnson; Harry A. Quigley; Ian F. Pitha
TAGS: astrocytes, did not receive therapy or drug, eye, glaucoma, mice, neuroprotection, optic nerve disorders, phosphotransferases, proteins, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):43. https://doi.org/10.1167/iovs.65.13.43

Includes: Supplemental Content

Retinal Cell Biology November 2024

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

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Juliane Hammer; Paul Röppenack; Sarah Yousuf; Anja Machate; Marika Fischer; Stefan Hans; Michael Brand
TAGS: adult, zebrafish, phenotype, visual system, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):42. https://doi.org/10.1167/iovs.65.13.42

Includes: Supplemental Content

Cornea November 2024

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

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XiaoBo Zheng; Chong Wang; YiWen Fan; YuXin Hong; Han Bao; ErChi Zhang; Yi Jin; Peng Yang; LingQiao Li; JunJie Wang; ShiHao Chen; Ahmed Elsheikh; FangJun Bao
TAGS: cornea, oryctolagus cuniculus, travoprost, cardiac ct, multiple wake test, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):35. https://doi.org/10.1167/iovs.65.13.35

Glaucoma November 2024

Differentiating Multiple Sclerosis and Glaucoma With Sectoral Pattern Analysis of Peripapillary Nerve Fiber Layer

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Po-Han Yeh; Ou Tan; Elizabeth Silbermann; Elizabeth White; Dongseok Choi; Aiyin Chen; Eliesa Ing; Dennis Bourdette; Jie Wang; Yali Jia; David Huang
TAGS: eye, glaucoma, multiple sclerosis, nerve fibers
Trans. Vis. Sci. Tech.. 2024; 13(11):11. https://doi.org/10.1167/tvst.13.11.11

Glaucoma November 2024

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

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Xuejin Zhang; Ting Li; Rong Zhang; Junfeng Li; Kaidi Wang; Jihong Wu
TAGS: axon, down-regulation, glaucoma, ocular hypertension, optic nerve, retina, retinal ganglion cells, tissue degeneration, wounds and injuries, injections
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):7. https://doi.org/10.1167/iovs.65.13.7

Includes: Supplemental Content

Glaucoma November 2024

Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head

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Mingjuan Wu; Xinyi Zhao; Shanzhen Peng; Xiaoyu Zhang; Jiali Ru; Lijing Xie; Tao Wen; Yingchun Su; Shujuan Xu; Dianlei Guo; Jianmin Hu; Haotian Lin; Tiansen Li; Chunqiao Liu
TAGS: axonal transport, mice, optic disk, optic nerve, optic nerve disorders, axon, retina, hydrocephalus
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):5. https://doi.org/10.1167/iovs.65.13.5

Includes: Supplemental Content

Glaucoma November 2024

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

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Manik Bansal; Bingrui Wang; Susannah Waxman; Fuqiang Zhong; Yi Hua; Yuankai Lu; Juan Reynaud; Brad Fortune; Ian A. Sigal
TAGS: axon, body tissue, intraocular pressure, optic disk, volume, reconstructive surgical procedures
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):1. https://doi.org/10.1167/iovs.65.13.1

Includes: Supplemental Content

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Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

A Pattern-Based OCT Metric for Glaucoma Detection

Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Sizes III and V in Glaucoma and NAION

Sterile Caliper Anterior Chamber Decompression Mitigates Intraocular Pressure Spikes in Intravitreal Injections

A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

Relating Standardized Automated Perimetry Performed With Stimulus Sizes III and V in Eyes With Field Loss Due to Glaucoma and NAION

The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients

Sequence and Detectability of Changes in Macular Ganglion Cell Layer Thickness and Perfusion Density in Early Glaucoma

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

Author Response: Effect of Depth-Dependent Integrated Visual Field on Vision-Related Quality of Life in Glaucoma

Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study

The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

Differentiating Multiple Sclerosis and Glaucoma With Sectoral Pattern Analysis of Peripapillary Nerve Fiber Layer

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

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