Imaging

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Review January 2025

New Directions for Ophthalmic OCT – Handhelds, Surgery, and Robotics

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Julia Foust; Morgan McCloud; Amit Narawane; Robert M. Trout; Xi Chen; Al-Hafeez Dhalla; Jianwei D. Li; Christian Viehland; Mark Draelos; Lejla Vajzovic; Ryan P. McNabb; Anthony N. Kuo; Cynthia A. Toth
TAGS: eye, intraoperative care, robotics, surgical procedures, operative, diagnostic imaging, mobile devices
Trans. Vis. Sci. Tech.. 2025; 14(1):14. https://doi.org/10.1167/tvst.14.1.14

Physiology and Pharmacology January 2025

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

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Nina Riddell; Melanie J. Murphy; Sania Zahra; Isabella Robertson-Dixon; Sheila G. Crewther
TAGS: eye, lens (device), lens, crystalline, myopia, white light, blue light, refraction, photopsia, electroretinography, weight gain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):30. https://doi.org/10.1167/iovs.66.1.30

Includes: Supplemental Content

Retina January 2025

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

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Katharina Wall; Lilith P. Arend; Leon von der Emde; Marlene Saßmannshausen; Frank G. Holz; Thomas Ach
TAGS: diabetes mellitus, diagnostic imaging, optical coherence tomography, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(1):12. https://doi.org/10.1167/tvst.14.1.12

Retina January 2025

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

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Ines D. Nagel; Anna Heinke; Akshay P. Agnihotri; Shaden Yassin; Lingyun Cheng; Andrew S. Camp; Nathan L. Scott; Fritz Gerald P. Kalaw; Shyamanga Borooah; Dirk-Uwe G. Bartsch; Arthur J. Mueller; Nehal Mehta; William R. Freeman
TAGS: color, diagnostic imaging, lasers, minimal cognitive impairment, ophthalmoscopes, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(1):11. https://doi.org/10.1167/tvst.14.1.11

Retina January 2025

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

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Brandon D. Anderson; Brent A. Bell; Ying Song; Timothy T. Lee; Tan Wang; Joshua L. Dunaief
TAGS: age-related macular degeneration, nonexudative, atrophy, injections, iodates, sodium, mice, diagnostic imaging, retina
Trans. Vis. Sci. Tech.. 2025; 14(1):9. https://doi.org/10.1167/tvst.14.1.9

Includes: Supplemental Content

Retina January 2025

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

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Federico Corti; Filippo Locri; Flavia Plastino; Paola Perrotta; Krisztina Zsebo; Emma Ristori; Xiangyun Yin; Eric Song; Helder André; Michael Simons
TAGS: antibodies, choroidal neovascularization, edema, inflammation, lasers, mice, syndecan, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, intravitreal injections
Trans. Vis. Sci. Tech.. 2025; 14(1):10. https://doi.org/10.1167/tvst.14.1.10

Includes: Supplemental Content

Glaucoma January 2025

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

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Daniel Kim; Raymond Fang; Pengpeng Zhang; Zihang Yan; Cheng Sun; Guorong Li; Christa Montgomery; Simon W. M. John; W. Daniel Stamer; Hao F. Zhang; C. Ross Ethier
TAGS: anterior chamber of eye, aqueous humor, diagnostic imaging, eye, mice, vaccine information sheets, volume, x-ray microtomography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):18. https://doi.org/10.1167/iovs.66.1.18

Includes: Supplemental Content

Immunology and Microbiology January 2025

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

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Verena Behnke; Anne Wolf; Mandy Hector; Thomas Langmann
TAGS: anaphylatoxins, mice, retina, retinal degeneration, white light, complement system proteins, complement membrane attack complex
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):15. https://doi.org/10.1167/iovs.66.1.15

Includes: Supplemental Content

Retina January 2025

Slab-Specific Projection-Resolved Optical Coherence Tomography Angiography for Enhancing En Face Polyp Detection in Polypoidal Choroidal Vasculopathy

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Nida Wongchaisuwat; Jie Wang; Tristan T. Hormel; Yali Jia; Elizabeth S. White; Nuttawut Rodanant; Nopasak Phasukkijwatana
TAGS: angiogram, face, polypoidal choroidal vasculopathy, polyps, optical coherence tomography, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):9. https://doi.org/10.1167/iovs.66.1.9

Article January 2025

Improving the reliability and accuracy of population receptive field measures using a logarithmically warped stimulus

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Kelly Chang; Ione Fine; Geoffrey M. Boynton
TAGS: prolactin-releasing hormone, reliability
Journal of Vision. 2025; 25(1):5. https://doi.org/10.1167/jov.25.1.5

Retina January 2025

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

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German Pinedo-Diaz; Birgit Lorenz; Sandrine H. Künzel; Sarah Thiele; Susana Ortega-Cisneros; Eduardo Bayro Corrochano; Frank G. Holz; Alexander Effland
TAGS: retina, rpe65 protein, spectral domain-optical coherence tomography, biological markers, deep learning, mutation, gene therapy, datasets
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):5. https://doi.org/10.1167/iovs.66.1.5

Includes: Supplemental Content

Retina January 2025

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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Deng Pan; Ge Hu; Jiayue Li; Zixu Wang; Yaoxing Chen; Jing Cao
TAGS: autophagy, chickens, stress, retina, blue light, endoplasmic reticulum, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):3. https://doi.org/10.1167/iovs.66.1.3

Includes: Supplemental Content

Retina December 2024

Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy

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Dhavamani Sugasini; Poorna C. R. Yalagala; Jason C. Park; Guangying Ma; Zeenat Farooq; Basma Baccouche; Onkar B. Sawant; J. Jason McAnany; Xincheng Yao; Andrius Kazlauskas; Brian T. Layden; Papasani V. Subbaiah
TAGS: diabetes mellitus, diabetic retinopathy, fatty acids, mice, retina, docosahexaenoic acids, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):39. https://doi.org/10.1167/iovs.65.14.39

Includes: Supplemental Content

Retina December 2024

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

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Lukas Goerdt; Jose Luis Rodriguez Garcia; Sandrine H. Künzel; Kristina Pfau; Kristin Raming; Simone Tzaridis; Matthias Schmid; Frank G. Holz; Ben Isselmann; Leonie Weinhold; Sarah Thiele
TAGS: patient prognosis, telangiectasis, spectral domain-optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):36. https://doi.org/10.1167/iovs.65.14.36

Glaucoma December 2024

Clinical Validation of M-TONX: A Novel Combo Rebound Tonometer and Pachymeter

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Naveed Nilforushan; Mozafar Yousefi; Ankica Babic; Arash Gharehbaghi
TAGS: cardiac ct, intraocular pressure, tonometers, cornea
Trans. Vis. Sci. Tech.. 2024; 13(12):34. https://doi.org/10.1167/tvst.13.12.34

Artificial Intelligence December 2024

A Deep Learning Network for Accurate Retinal Multidisease Diagnosis Using Multiview Fusion of En Face and B-Scan Images: A Multicenter Study

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Chubin Ou; Xifei Wei; Lin An; Jia Qin; Min Zhu; Mei Jin; Xiangbin Kong
TAGS: deep learning, face, multicenter studies
Trans. Vis. Sci. Tech.. 2024; 13(12):31. https://doi.org/10.1167/tvst.13.12.31

Includes: Supplemental Content

Cornea & External Disease December 2024

In Vivo Contactless, Cellular-Resolution Imaging of the Healthy and Pathological Human Limbus With 250-kHz Point-Scanning SD-OCT

PDF

Kostadinka Bizheva; Zohreh Hosseinaee; Kirsten Carter; Denise Hileeto; Brian G. Ballios; Luigina Sorbara; Hall F. Chew
TAGS: body tissue, diagnostic imaging, spectral domain-optical coherence tomography, eye, cicatrix
Trans. Vis. Sci. Tech.. 2024; 13(12):29. https://doi.org/10.1167/tvst.13.12.29

Cornea & External Disease December 2024

Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy

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Ioannis N. Petropoulos; Kareem Essam Aly; Shaikha Al-Thani; Georgios Ponirakis; Hoda Gad; Adnan Khan; Beatriz Canibano; Dirk Deleu; Naveed Akhtar; Gayane Melikyan; Boulenouar Mesraoua; Maria Siddiqi; Jon Perkins; Novsheen Mir; Reny Francis; Abdul Salam; Ahmed El-Sotouhy; Surjith Vattoth; Ahmed Own; Saadat Kamran; Rayaz A. Malik
TAGS: cornea, epilepsy, microscopy, confocal, multiple sclerosis, nerve degeneration
Trans. Vis. Sci. Tech.. 2024; 13(12):22. https://doi.org/10.1167/tvst.13.12.22

Retina December 2024

Band Visibility in High-Resolution Optical Coherence Tomography Assessed With a Custom Review Tool and Updated, Histology-Derived Nomenclature

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Lukas Goerdt; Thomas A. Swain; Deepayan Kar; Gerald McGwin; Andreas Berlin; Mark E. Clark; Cynthia Owsley; Kenneth R. Sloan; Christine A. Curcio
TAGS: eye, histology, optical coherence tomography, retina, software, reliability, volume electron microscopy, diagnostic imaging
Trans. Vis. Sci. Tech.. 2024; 13(12):19. https://doi.org/10.1167/tvst.13.12.19

Includes: Multimedia, Supplemental Content

Clinical Trials December 2024

A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry

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Viktoria Pai; Patrick Janku; Theresa Lindner; Ulrich Graf; Leopold Schmetterer; Gerhard Garhöfer; Doreen Schmidl
TAGS: lasers, oximetry, oxygen, oxygen extraction, oxygen saturation measurement, vascular flow, hypoxia, inspiration, respiration, hyperoxia
Trans. Vis. Sci. Tech.. 2024; 13(12):12. https://doi.org/10.1167/tvst.13.12.12

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New Directions for Ophthalmic OCT – Handhelds, Surgery, and Robotics

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

Slab-Specific Projection-Resolved Optical Coherence Tomography Angiography for Enhancing En Face Polyp Detection in Polypoidal Choroidal Vasculopathy

Improving the reliability and accuracy of population receptive field measures using a logarithmically warped stimulus

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

Clinical Validation of M-TONX: A Novel Combo Rebound Tonometer and Pachymeter

A Deep Learning Network for Accurate Retinal Multidisease Diagnosis Using Multiview Fusion of En Face and B-Scan Images: A Multicenter Study

In Vivo Contactless, Cellular-Resolution Imaging of the Healthy and Pathological Human Limbus With 250-kHz Point-Scanning SD-OCT

Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy

Band Visibility in High-Resolution Optical Coherence Tomography Assessed With a Custom Review Tool and Updated, Histology-Derived Nomenclature

A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry

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