Immunology and Microbiology

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Retinal Cell Biology December 2024

Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis

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Joshua Glass; Rebekah Robinson; Neel Edupuganti; Jeremy Altman; Grace Greenway; Tae Jin Lee; Wenbo Zhi; Ashok Sharma; Shruti Sharma
TAGS: interleukin-6, proteins, neuroglia, mice, interleukin 6 receptor
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):33. https://doi.org/10.1167/iovs.65.14.33

Includes: Supplemental Content

Methods December 2024

Using Hierarchical Bayesian Modeling to Enhance Statistical Inference on Contrast Sensitivity

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Yukai Zhao; Luis Andres Lesmes; Michael Dorr; Zhong-Lin Lu
TAGS: carotid sinus syncope, churg-strauss syndrome, contrast sensitivity, inference, luminance, datasets
Trans. Vis. Sci. Tech.. 2024; 13(12):17. https://doi.org/10.1167/tvst.13.12.17

Includes: Supplemental Content

Cornea & External Disease December 2024

Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy

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Ioannis N. Petropoulos; Kareem Essam Aly; Shaikha Al-Thani; Georgios Ponirakis; Hoda Gad; Adnan Khan; Beatriz Canibano; Dirk Deleu; Naveed Akhtar; Gayane Melikyan; Boulenouar Mesraoua; Maria Siddiqi; Jon Perkins; Novsheen Mir; Reny Francis; Abdul Salam; Ahmed El-Sotouhy; Surjith Vattoth; Ahmed Own; Saadat Kamran; Rayaz A. Malik
TAGS: cornea, epilepsy, microscopy, confocal, multiple sclerosis, nerve degeneration
Trans. Vis. Sci. Tech.. 2024; 13(12):22. https://doi.org/10.1167/tvst.13.12.22

Cornea & External Disease December 2024

The Effect of Terpinen-4-ol on Human Corneal Epithelium

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Joo-Hee Park; Choul Yong Park
TAGS: cell survival, cornea, corneal epithelium, epithelium, toxic effect, corneal epithelial cells, mass or substance concentration per volume, cell count, eyelid scrub, immunocytochemistry
Trans. Vis. Sci. Tech.. 2024; 13(12):18. https://doi.org/10.1167/tvst.13.12.18

Includes: Supplemental Content

Immunology and Microbiology December 2024

Itaconate Ameliorates Experimental Autoimmune Uveitis by Modulating Teff/Treg Cell Imbalance Via the DNAJA1/CDC45 Axis

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Qi Jiang; Zhaohuai Li; Yao Huang; Zhaohao Huang; Junjie Chen; Xiuxing Liu; Chun Zhang; Chenyang Gu; Tianfu Wang; He Li; Yingqi Li; Wenru Su
TAGS: autoimmunity, flow cytometry, imbalance, itaconate, mice, regulatory t-lymphocytes, t-lymphocytes, uveitis, inflammation, th17 cells
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):23. https://doi.org/10.1167/iovs.65.14.23

Includes: Supplemental Content

Lens December 2024

Mefunidone Inhibits Inflammation, Oxidative Stress, and Epithelial-Mesenchymal Transition in Lens Epithelial Cells

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Cong Fan; Yu Yang; Mengling You; Zhuo Chen; Jian Jiang
TAGS: epithelial to mesenchymal transition, inflammation, lens epithelial cell, oxidative stress, surgical procedures, operative, western blotting, mitogen-activated protein kinases, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):17. https://doi.org/10.1167/iovs.65.14.17

Includes: Supplemental Content

Cornea December 2024

Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease

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Xin Zuo; Hao Zeng; Xue Yang; Dalian He; Bowen Wang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, loeys-dietz syndrome, proteins, stress, western blotting, autophagy, lipid peroxidation, lysosomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):12. https://doi.org/10.1167/iovs.65.14.12

Includes: Supplemental Content

Letters to the Editor December 2024

Is This Inflammation, Conjunctiva-Associated Lymphoid Tissue, or Tertiary Lymphoid Structures in These Rabbits?

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JoAnn C. L. Schuh
TAGS: conjunctiva, inflammation, lymphoid tissue, oryctolagus cuniculus, tertiary lymphoid structures
Trans. Vis. Sci. Tech.. 2024; 13(12):3. https://doi.org/10.1167/tvst.13.12.3

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2024

The Impact of HLA-A29 Homozygosity and of the Second HLA-A Allele on Susceptibility and Severity of Birdshot Chorioretinitis

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Jordan Loeliger; Romain Lhotte; Sahar Gelfman; Eli A. Stahl; Dominique Monnet; Valentin Clichet; Linda Imikirene; Souhila Kecili; Jean-Luc Taupin; Thierry Tabary; Jacques H. M. Cohen; Antoine P. Brézin
TAGS: alleles, disease susceptibility, hla-a antigens, homozygote, human leukocyte antigens, vitiliginous chorioretinitis
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):47. https://doi.org/10.1167/iovs.65.13.47

Includes: Supplemental Content

Cornea & External Disease November 2024

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

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Hao-Yu Wang; Dan Shen; Meng-Ying Qi; Chen Qiao; Lan Ke; Mingwu Wang; Qing-Yan Zeng
TAGS: blepharitis, eyelid, mites, ocular surfaces, eyelid margin, follow-up
Trans. Vis. Sci. Tech.. 2024; 13(11):22. https://doi.org/10.1167/tvst.13.11.22

Biochemistry and Molecular Biology November 2024

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

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Charkira C. Patrick; Elisa Roztocil; Farha Husain; Steven E. Feldon; Collynn F. Woeller
TAGS: aryl hydrocarbon receptor, fibroblasts, graves' ophthalmopathy, ligands, signal transduction, tapinarof, platelet-derived growth factor, thymidylate synthase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):40. https://doi.org/10.1167/iovs.65.13.40

Includes: Supplemental Content

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Cornea November 2024

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

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Xiaowei Yang; Xingwu Zhong; Haotian Lin; Andrew J.W. Huang; Lixing W. Reneker
TAGS: atrophy, epithelium, fgfr2 gene, meibomian gland dysfunction, mice, tamoxifen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):36. https://doi.org/10.1167/iovs.65.13.36

Includes: Supplemental Content

Retina November 2024

High Intraocular Concentration of Fibrinogen Regulates Retinal Function Via the ICAM-1 Pathway

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Yasuyuki Sotani; Hisanori Imai; Hiroko Yamada; Akiko Miki; Sentaro Kusuhara; Makoto Nakamura
TAGS: fibrinogen, intercellular adhesion molecule 1, mass or substance concentration per volume, intravitreal injections, mice, antibodies
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):34. https://doi.org/10.1167/iovs.65.13.34

Biochemistry and Molecular Biology November 2024

Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

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Seung Hyun Park; Soo Hyun Choi; Hyun Young Park; JaeSang Ko; Jin Sook Yoon
TAGS: body tissue, fibroblasts, oxidase, pathogenesis, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):33. https://doi.org/10.1167/iovs.65.13.33

Includes: Supplemental Content

Glaucoma November 2024

Differentiating Multiple Sclerosis and Glaucoma With Sectoral Pattern Analysis of Peripapillary Nerve Fiber Layer

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Po-Han Yeh; Ou Tan; Elizabeth Silbermann; Elizabeth White; Dongseok Choi; Aiyin Chen; Eliesa Ing; Dennis Bourdette; Jie Wang; Yali Jia; David Huang
TAGS: eye, glaucoma, multiple sclerosis, nerve fibers
Trans. Vis. Sci. Tech.. 2024; 13(11):11. https://doi.org/10.1167/tvst.13.11.11

Retinal Cell Biology November 2024

Genetic and Cellular Basis of Impaired Phagocytosis and Photoreceptor Degeneration in CLN3 Disease

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Jimin Han; Sueanne Chear; Jana Talbot; Vicki Swier; Clarissa Booth; Cheyenne Reuben-Thomas; Sonal Dalvi; Jill M. Weimer; Alex W. Hewitt; Anthony L. Cook; Ruchira Singh
TAGS: autofluorescence, phagocytosis, photoreceptors, platypnea orthodeoxia syndrome, retinal pigment cell, tissue degeneration, genetics, lipofuscin, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):23. https://doi.org/10.1167/iovs.65.13.23

Includes: Supplemental Content

Immunology and Microbiology November 2024

γδ T17 Cells Regulate the Acute Antiviral Response of NK Cells in HSV-1–Infected Corneas

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Rachel R. Rodenberg; Domenico Spadafora; Steffani Fitzpatrick; Grant Daly; Robert Lausch; Robert A. Barrington
TAGS: antiviral agents, cornea, human herpesvirus 1, interleukin-17, mice, natural killer cells, infections
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):16. https://doi.org/10.1167/iovs.65.13.16

Includes: Supplemental Content

Retinal Cell Biology November 2024

Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy

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Ahmed M. Awad; Amritha T. M. Seetharaman; Mohammad Shahadat Hossain; Sally L. Elshaer; Rania R. Abdelaziz; Manar A. Nader; Rajashekhar Gangaraju
TAGS: autophagy, diabetes mellitus, endothelial cells, endothelium, hyperglycemia, montelukast, tumor necrosis factors, antagonists, leukotriene receptor, inflammation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):15. https://doi.org/10.1167/iovs.65.13.15

Includes: Supplemental Content

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Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis

Using Hierarchical Bayesian Modeling to Enhance Statistical Inference on Contrast Sensitivity

Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy

The Effect of Terpinen-4-ol on Human Corneal Epithelium

Itaconate Ameliorates Experimental Autoimmune Uveitis by Modulating Teff/Treg Cell Imbalance Via the DNAJA1/CDC45 Axis

Mefunidone Inhibits Inflammation, Oxidative Stress, and Epithelial-Mesenchymal Transition in Lens Epithelial Cells

Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease

Is This Inflammation, Conjunctiva-Associated Lymphoid Tissue, or Tertiary Lymphoid Structures in These Rabbits?

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

The Impact of HLA-A29 Homozygosity and of the Second HLA-A Allele on Susceptibility and Severity of Birdshot Chorioretinitis

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

High Intraocular Concentration of Fibrinogen Regulates Retinal Function Via the ICAM-1 Pathway

Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

Differentiating Multiple Sclerosis and Glaucoma With Sectoral Pattern Analysis of Peripapillary Nerve Fiber Layer

Genetic and Cellular Basis of Impaired Phagocytosis and Photoreceptor Degeneration in CLN3 Disease

γδ T17 Cells Regulate the Acute Antiviral Response of NK Cells in HSV-1–Infected Corneas

Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy

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