Pharmacology

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Retina December 2024

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

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David S. Boyer; Nathan C. Steinle; Joel A. Pearlman; Cameron M. Stone; Courtney Crawford; Sunil Gupta; Pravin U. Dugel; Megan E. Baldwin; Ian M. Leitch
TAGS: aflibercept, diabetic macular edema, vascular endothelial growth factor a, vascular endothelial growth factor c, vascular endothelial growth factors
Trans. Vis. Sci. Tech.. 2024; 13(12):32. https://doi.org/10.1167/tvst.13.12.32

Lens December 2024

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

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Yu Yang; Cong Fan; Yue Zhang; Tianyi Kang; Jian Jiang
TAGS: diabetes mellitus, lens (device), lens, crystalline, metabolites, mice, retina, streptozocin, metabolic disturbance, lipocalin-2 protein, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):19. https://doi.org/10.1167/iovs.65.14.19

Includes: Supplemental Content

Anatomy and Pathology/Oncology December 2024

Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

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María Belen Cancela; Ursula Winter; Santiago Zugbi; Milagros Dinardi; Daniela Alves da Quinta; Rosario Aschero; Daiana Ganiewich; Claudia Sampor; Mariana Sgroi; Eduardo Lagomarsino; Adriana Fandiño; Andrea S. Llera; Guillermo Chantada; Angel M. Carcaboso; Paula Schaiquevich
TAGS: melphalan, retinoblastoma, topotecan, parent, membrane transport proteins, inhibitory concentration 50
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):14. https://doi.org/10.1167/iovs.65.14.14

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2024

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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Panagiotis Laspas; Alica Hartmann; Ida Scholz; Esther Maria Hoffmann; Anthony P. Khawaja; Karl Johannes Lackner; Thomas Münzel; Jasmin Ghaemi Kerahrodi; Irene Schmidtmann; Oliver Tüscher; Jörn Markus Schattenberg; Norbert Pfeiffer; Stavros Konstantinides; Philipp Sebastian Wild; Alexander Karl-Georg Schuster
TAGS: intraocular pressure, pharmaceutical preparations, health, beta-blockers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):4. https://doi.org/10.1167/iovs.65.14.4

Includes: Supplemental Content

Physiology and Pharmacology November 2024

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

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Sabrina Wohlfart; Jonathan Herth; Manuel Ben Böhmann; Giulia Pander; Lorenz Herbster; Walter Mier; Gerd Uwe Auffarth; Philipp Uhl; Maximilian Hammer
TAGS: antibodies, anti-vascular endothelial growth factor therapy, bevacizumab, silicone oils, trastuzumab, vascular endothelial growth factor a, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):56. https://doi.org/10.1167/iovs.65.13.56

Includes: Supplemental Content

Retina November 2024

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

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David A. Antonetti; Cheng-Mao Lin; Sumathi Shanmugam; Heather Hager; Manjing Cao; Xuwen Liu; Alyssa Dreffs; Adam Habash; Steven F. Abcouwer
TAGS: diabetes mellitus, wounds and injuries, mice, retina, photoreceptors, reperfusion injury, streptozocin
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):46. https://doi.org/10.1167/iovs.65.13.46

Includes: Supplemental Content

Retina November 2024

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

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Nicole A. Muench; Heather M. Schmitt; Cassandra L. Schlamp; An-Jey A. Su; Kia Washington; Robert W. Nickells
TAGS: cryopreservation, eye, mice
Trans. Vis. Sci. Tech.. 2024; 13(11):24. https://doi.org/10.1167/tvst.13.11.24

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2024

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

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Charkira C. Patrick; Elisa Roztocil; Farha Husain; Steven E. Feldon; Collynn F. Woeller
TAGS: aryl hydrocarbon receptor, fibroblasts, graves' ophthalmopathy, ligands, signal transduction, tapinarof, platelet-derived growth factor, thymidylate synthase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):40. https://doi.org/10.1167/iovs.65.13.40

Includes: Supplemental Content

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Cornea November 2024

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

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Xiaowei Yang; Xingwu Zhong; Haotian Lin; Andrew J.W. Huang; Lixing W. Reneker
TAGS: atrophy, epithelium, fgfr2 gene, meibomian gland dysfunction, mice, tamoxifen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):36. https://doi.org/10.1167/iovs.65.13.36

Includes: Supplemental Content

Cornea November 2024

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

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XiaoBo Zheng; Chong Wang; YiWen Fan; YuXin Hong; Han Bao; ErChi Zhang; Yi Jin; Peng Yang; LingQiao Li; JunJie Wang; ShiHao Chen; Ahmed Elsheikh; FangJun Bao
TAGS: cornea, oryctolagus cuniculus, travoprost, cardiac ct, multiple wake test, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):35. https://doi.org/10.1167/iovs.65.13.35

Retina November 2024

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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Huan Liu; Feiyan Wang; Ziqing Hu; Jing Wei
TAGS: diabetic retinopathy, drug delivery systems, mendelian randomization analysis, plasma proteins, proteins
Trans. Vis. Sci. Tech.. 2024; 13(11):17. https://doi.org/10.1167/tvst.13.11.17

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

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Cheikh Diack; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Jacques Gaudreault; Katrijn Bogman; Valerie Cosson
TAGS: faricimab, intravitreal injections, retinal diseases, pharmacokinetics, hypertension, plasma
Trans. Vis. Sci. Tech.. 2024; 13(11):14. https://doi.org/10.1167/tvst.13.11.14

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

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Cheikh Diack; Robert L. Avery; Chui Ming Gemmy Cheung; Karl G. Csaky; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Denise Sickert; Ivo Stoilov; Valerie Cosson; Katrijn Bogman
TAGS: diabetic macular edema, exudative age-related macular degeneration, faricimab, hypertension, vascular endothelial growth factor a, pharmacodynamics
Trans. Vis. Sci. Tech.. 2024; 13(11):13. https://doi.org/10.1167/tvst.13.11.13

Includes: Supplemental Content

Glaucoma November 2024

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

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Kenzo Yamamura; Hidetoshi Mano; Masahiro Fuwa; Ryo Iwamura; Noriko Odani-Kawabata
TAGS: cercopithecidae, drug or chemical tissue distribution, macaca fascicularis, omidenepag, oryctolagus cuniculus, radioactivity, cornea, eye, aqueous humor, administration, topical
Trans. Vis. Sci. Tech.. 2024; 13(11):6. https://doi.org/10.1167/tvst.13.11.6

Retinal Cell Biology November 2024

Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy

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Ahmed M. Awad; Amritha T. M. Seetharaman; Mohammad Shahadat Hossain; Sally L. Elshaer; Rania R. Abdelaziz; Manar A. Nader; Rajashekhar Gangaraju
TAGS: autophagy, diabetes mellitus, endothelial cells, endothelium, hyperglycemia, montelukast, tumor necrosis factors, antagonists, leukotriene receptor, inflammation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):15. https://doi.org/10.1167/iovs.65.13.15

Includes: Supplemental Content

Retina October 2024

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

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Patricia Lamirande; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Jessica R. Crawshaw; Antonello Caruso
TAGS: drug delivery systems, eye, injections, vitreous body, immunoglobulin g, molecule, drug elimination routes, drug excretion
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):21. https://doi.org/10.1167/iovs.65.12.21

Includes: Supplemental Content

Physiology and Pharmacology October 2024

Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment

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Sina Bahrpeyma; Paulina Jakubiak; Rubén Alvarez-Sánchez; Antonello Caruso; Monika Leuthardt; Claudia Senn; Eva M. del Amo; Arto Urtti
TAGS: body tissue, drug delivery, targeted, eyedrops, levofloxacin, melanins, oryctolagus cuniculus, albinism, multiple-dose regimen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):14. https://doi.org/10.1167/iovs.65.12.14

Includes: Supplemental Content

Retina October 2024

Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells

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Wenyi Zhang; Xin Wang; Shuwei Tian; Jianming Wang; Aiyi Zhou
TAGS: insulin, insulin resistance, retina, alpha-fetoproteins, glucose
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):16. https://doi.org/10.1167/iovs.65.12.16

Includes: Supplemental Content

Glaucoma October 2024

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

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Yooree G. Chung; Shan Fan; Vikas Gulati; Hoi-Lam Li; Haiyan Gong; Carol B. Toris; Mark R. Prausnitz; C. Ross Ethier
TAGS: hydrogel, injections, intraocular pressure, eye, hypertension
Trans. Vis. Sci. Tech.. 2024; 13(10):14. https://doi.org/10.1167/tvst.13.10.14

Includes: Supplemental Content

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Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment

Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

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