Retinal Imaging

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Physiology and Pharmacology January 2025

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

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Nina Riddell; Melanie J. Murphy; Sania Zahra; Isabella Robertson-Dixon; Sheila G. Crewther
TAGS: eye, lens (device), lens, crystalline, myopia, white light, blue light, refraction, photopsia, electroretinography, weight gain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):30. https://doi.org/10.1167/iovs.66.1.30

Includes: Supplemental Content

Retina January 2025

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

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Katharina Wall; Lilith P. Arend; Leon von der Emde; Marlene Saßmannshausen; Frank G. Holz; Thomas Ach
TAGS: diabetes mellitus, diagnostic imaging, optical coherence tomography, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(1):12. https://doi.org/10.1167/tvst.14.1.12

Retina January 2025

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

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Ines D. Nagel; Anna Heinke; Akshay P. Agnihotri; Shaden Yassin; Lingyun Cheng; Andrew S. Camp; Nathan L. Scott; Fritz Gerald P. Kalaw; Shyamanga Borooah; Dirk-Uwe G. Bartsch; Arthur J. Mueller; Nehal Mehta; William R. Freeman
TAGS: color, diagnostic imaging, lasers, minimal cognitive impairment, ophthalmoscopes, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(1):11. https://doi.org/10.1167/tvst.14.1.11

Retina January 2025

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

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Federico Corti; Filippo Locri; Flavia Plastino; Paola Perrotta; Krisztina Zsebo; Emma Ristori; Xiangyun Yin; Eric Song; Helder André; Michael Simons
TAGS: antibodies, choroidal neovascularization, edema, inflammation, lasers, mice, syndecan, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, intravitreal injections
Trans. Vis. Sci. Tech.. 2025; 14(1):10. https://doi.org/10.1167/tvst.14.1.10

Includes: Supplemental Content

Immunology and Microbiology January 2025

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

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Verena Behnke; Anne Wolf; Mandy Hector; Thomas Langmann
TAGS: anaphylatoxins, mice, retina, retinal degeneration, white light, complement system proteins, complement membrane attack complex
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):15. https://doi.org/10.1167/iovs.66.1.15

Includes: Supplemental Content

Article January 2025

Improving the reliability and accuracy of population receptive field measures using a logarithmically warped stimulus

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Kelly Chang; Ione Fine; Geoffrey M. Boynton
TAGS: prolactin-releasing hormone, reliability
Journal of Vision. 2025; 25(1):5. https://doi.org/10.1167/jov.25.1.5

Retina January 2025

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

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German Pinedo-Diaz; Birgit Lorenz; Sandrine H. Künzel; Sarah Thiele; Susana Ortega-Cisneros; Eduardo Bayro Corrochano; Frank G. Holz; Alexander Effland
TAGS: retina, rpe65 protein, spectral domain-optical coherence tomography, biological markers, deep learning, mutation, gene therapy, datasets
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):5. https://doi.org/10.1167/iovs.66.1.5

Includes: Supplemental Content

Retina January 2025

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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Deng Pan; Ge Hu; Jiayue Li; Zixu Wang; Yaoxing Chen; Jing Cao
TAGS: autophagy, chickens, stress, retina, blue light, endoplasmic reticulum, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):3. https://doi.org/10.1167/iovs.66.1.3

Includes: Supplemental Content

Retina December 2024

Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy

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Dhavamani Sugasini; Poorna C. R. Yalagala; Jason C. Park; Guangying Ma; Zeenat Farooq; Basma Baccouche; Onkar B. Sawant; J. Jason McAnany; Xincheng Yao; Andrius Kazlauskas; Brian T. Layden; Papasani V. Subbaiah
TAGS: diabetes mellitus, diabetic retinopathy, fatty acids, mice, retina, docosahexaenoic acids, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):39. https://doi.org/10.1167/iovs.65.14.39

Includes: Supplemental Content

Retina December 2024

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

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Lukas Goerdt; Jose Luis Rodriguez Garcia; Sandrine H. Künzel; Kristina Pfau; Kristin Raming; Simone Tzaridis; Matthias Schmid; Frank G. Holz; Ben Isselmann; Leonie Weinhold; Sarah Thiele
TAGS: patient prognosis, telangiectasis, spectral domain-optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):36. https://doi.org/10.1167/iovs.65.14.36

Artificial Intelligence December 2024

A Deep Learning Network for Accurate Retinal Multidisease Diagnosis Using Multiview Fusion of En Face and B-Scan Images: A Multicenter Study

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Chubin Ou; Xifei Wei; Lin An; Jia Qin; Min Zhu; Mei Jin; Xiangbin Kong
TAGS: deep learning, face, multicenter studies
Trans. Vis. Sci. Tech.. 2024; 13(12):31. https://doi.org/10.1167/tvst.13.12.31

Includes: Supplemental Content

Clinical Trials December 2024

A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry

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Viktoria Pai; Patrick Janku; Theresa Lindner; Ulrich Graf; Leopold Schmetterer; Gerhard Garhöfer; Doreen Schmidl
TAGS: lasers, oximetry, oxygen, oxygen extraction, oxygen saturation measurement, vascular flow, hypoxia, inspiration, respiration, hyperoxia
Trans. Vis. Sci. Tech.. 2024; 13(12):12. https://doi.org/10.1167/tvst.13.12.12

Biochemistry and Molecular Biology December 2024

Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease

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Bushra Rahman; David M. G. Anderson; Chunhe Chen; Jian Liu; Lukasz G. Migas; Raf Van de Plas; Kevin L. Schey; Masahiro Kono; Jie Fan; Yiannis Koutalos
TAGS: chromophore, mice, niemann-pick diseases, retina, sphingolipids, vitamin a, spectrometry, mass, matrix-assisted laser desorption-ionization, sphingomyelins, diagnostic imaging, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):24. https://doi.org/10.1167/iovs.65.14.24

Retina December 2024

Retinal Neurovascular Impairment in Full-Course Diabetic Retinopathy: The Guangdong Diabetic Retinopathy Multiple-Omics Study

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Chunran Lai; Ting Su; Jiahui Cao; Qinyi Li; Zijing Du; Yaxin Wang; Shan Wang; Qiaowei Wu; Yijun Hu; Ying Fang; Huiyi Liao; Zhuoting Zhu; Xianwen Shang; Mingguang He; Honghua Yu; Xiayin Zhang
TAGS: diabetes mellitus, type 2, diabetic retinopathy, electroretinography, nonproliferative diabetic retinopathy, peripheral neurovascular compromise, photopsia, retinal cone, optical coherence tomography, retina, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):20. https://doi.org/10.1167/iovs.65.14.20

Includes: Supplemental Content

Retina December 2024

Onset and Progression of Disease in Nonhuman Primates With PDE6C Cone Disorder

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Monica Ardon; Lily Nguyen; Rui Chen; Jeffrey Rogers; Tim Stout; Sara Thomasy; Ala Moshiri
TAGS: disease progression, electroretinography, homozygote, infant, mutation, primates, retinal cone, macaca, adult, heterozygote
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):16. https://doi.org/10.1167/iovs.65.14.16

Includes: Supplemental Content

Retinal Cell Biology November 2024

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

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Juliane Hammer; Paul Röppenack; Sarah Yousuf; Anja Machate; Marika Fischer; Stefan Hans; Michael Brand
TAGS: adult, zebrafish, phenotype, visual system, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):42. https://doi.org/10.1167/iovs.65.13.42

Includes: Supplemental Content

Retina November 2024

A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks

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Saman Ebrahimi; Phillip Bedggood; Yifu Ding; Andrew Metha; Prosenjit Bagchi
TAGS: blood capillaries, blood cells, computer simulation, fluid flow, hematocrit, hemodynamics, microcirculation, microvascular network, velocity, retail clinics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):37. https://doi.org/10.1167/iovs.65.13.37

Includes: Multimedia, Supplemental Content

Retinal Cell Biology November 2024

Genetic and Cellular Basis of Impaired Phagocytosis and Photoreceptor Degeneration in CLN3 Disease

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Jimin Han; Sueanne Chear; Jana Talbot; Vicki Swier; Clarissa Booth; Cheyenne Reuben-Thomas; Sonal Dalvi; Jill M. Weimer; Alex W. Hewitt; Anthony L. Cook; Ruchira Singh
TAGS: autofluorescence, phagocytosis, photoreceptors, platypnea orthodeoxia syndrome, retinal pigment cell, tissue degeneration, genetics, lipofuscin, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):23. https://doi.org/10.1167/iovs.65.13.23

Includes: Supplemental Content

Visual Neuroscience November 2024

The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism

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Zihe Xu; Jit Kai Tan; Krishnika Vetrivel; Xiaofan Jiang; Shaun M. Leo; Taha Bhatti; Ambreen Tariq; Andrew R. Webster; Anthony G. Robson; Christopher J. Hammond; Pirro G. Hysi; Omar A. Mahroo
TAGS: electroretinography, genetic risk, myopia, polymorphism
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):21. https://doi.org/10.1167/iovs.65.13.21

Includes: Supplemental Content

Retina November 2024

Factors Associated With Ocular Perfusion Measurements as Obtained With Laser Speckle Contrast Imaging

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Jacqueline Fröhlich; Marco Cattaneo; Philippe Valmaggia; Peter M. Maloca; Konstantin Gugleta; Leopold Schmetterer; Hendrik P.N. Scholl; Giacomo Calzetti
TAGS: laser speckle contrast imaging, optic disk, perfusion, vascular flow, eye, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2024; 13(11):8. https://doi.org/10.1167/tvst.13.11.8

Includes: Supplemental Content

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Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

Improving the reliability and accuracy of population receptive field measures using a logarithmically warped stimulus

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

A Deep Learning Network for Accurate Retinal Multidisease Diagnosis Using Multiview Fusion of En Face and B-Scan Images: A Multicenter Study

A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry

Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease

Retinal Neurovascular Impairment in Full-Course Diabetic Retinopathy: The Guangdong Diabetic Retinopathy Multiple-Omics Study

Onset and Progression of Disease in Nonhuman Primates With PDE6C Cone Disorder

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks

Genetic and Cellular Basis of Impaired Phagocytosis and Photoreceptor Degeneration in CLN3 Disease

The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism

Factors Associated With Ocular Perfusion Measurements as Obtained With Laser Speckle Contrast Imaging

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